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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 46(1-4)

Gluconeogenesis and Ammonia Production in the Isolated Perfused Rat Kidney : The Effect of Starvation, Acidosis and Diabetic Ketosis

https://doi.org/10.18999/nagjms.46.1-4.67
https://doi.org/10.18999/nagjms.46.1-4.67
9a339e94-4223-4f89-b55d-1e62d8350b61
名前 / ファイル ライセンス アクション
v46n14p67_78.pdf v46n14p67_78.pdf (948.3 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-02-08
タイトル
タイトル Gluconeogenesis and Ammonia Production in the Isolated Perfused Rat Kidney : The Effect of Starvation, Acidosis and Diabetic Ketosis
著者 GOTO, ENJIRO

× GOTO, ENJIRO

WEKO 98723

GOTO, ENJIRO

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SAKAKIBARA, FUMIHIKO

× SAKAKIBARA, FUMIHIKO

WEKO 98724

SAKAKIBARA, FUMIHIKO

Search repository
NISHIDA, TOMOATSU

× NISHIDA, TOMOATSU

WEKO 98725

NISHIDA, TOMOATSU

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KAWAMURA, TAKAHIKO

× KAWAMURA, TAKAHIKO

WEKO 98726

KAWAMURA, TAKAHIKO

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SANO, TAKAHISA

× SANO, TAKAHISA

WEKO 98727

SANO, TAKAHISA

Search repository
TSUCHIDA, ISAMU

× TSUCHIDA, ISAMU

WEKO 98728

TSUCHIDA, ISAMU

Search repository
SAKAMOTO, NOBUO

× SAKAMOTO, NOBUO

WEKO 98729

SAKAMOTO, NOBUO

Search repository
キーワード
主題Scheme Other
主題 Gluconeogenesis
キーワード
主題Scheme Other
主題 Ammonia production
キーワード
主題Scheme Other
主題 Isolated perfused rat kidney
抄録
内容記述 Isolated rat kidneys were perfused with a cell-free perfusate, and their creatinine clearance was found to be 106 μl/min./g wet weight. Gluconeogenesis from pyruvate, lactate, fructose, α-oxoglutarate, oxaloacetate, glutamate and glutamine as the substrates at a concentration of 10 mM and ammonia production from glutamine were studied in the kidneys from fasted rats, rats with NH4Cl-induced acidosis, and streptozotocin diabetic rats, using cell-free perfusates. 1. Fasting caused the gluconeogenesis from all substrates except pyruvate and the ammonia production from glutamine to increase. 2. In the kidneys from the rats with chronic acidosis, the gluconeogenesis from the substrates other than pyruvate, lactate and fructose was increased, and the gluconeogenesis and ammonia production from glutamine were both greater than those in the kidneys from the 7-day fasted rats. 3. In the kidneys from the streptozotocin diabetic rats, the gluconeogenesis from all substrates other than fructose was increased and was greater than that in the kidneys from the fasted rats and the rats with chronic acidosis. Also, despite the markedly increased gluconeogenesis from glutamine, ammonia production did not increase. From these findings, we believe that gluconeogenesis and ammonia production are not always coupled with each other, especially under some conditions in tho isolated perfused rat kidneys.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.46.1-4.67
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/4614/4614.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 46, 号 1-4, p. 67-78, 発行日 1984-03
著者版フラグ
値 publisher
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