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Effects of Acarbose, an α-Glucosidase Inhibitor (BAY G 5421), on Orally Loaded Glucose, Maltose and Sucrose and on Blood Glucose Control in Non-Insulin-Dependent Diabetics
https://doi.org/10.18999/nagjms.47.1-2.35
https://doi.org/10.18999/nagjms.47.1-2.35a6c2945d-c50a-4d8f-b6ee-2ca85ecff7e7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
v47n12p35_41.pdf (463.3 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-02-08 | |||||
| タイトル | ||||||
| タイトル | Effects of Acarbose, an α-Glucosidase Inhibitor (BAY G 5421), on Orally Loaded Glucose, Maltose and Sucrose and on Blood Glucose Control in Non-Insulin-Dependent Diabetics | |||||
| 言語 | en | |||||
| 著者 |
HAYAKAWA, TETUO
× HAYAKAWA, TETUO× NODA, AIJI× KONDO, TAKAHARU× OKUMURA, NOBUYOSHI |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | α-glucososidase inhibitor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | diabetes | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | saccharides tolerance test | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | insulin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | glucose | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Fifty g glucose, 50g maltose and 50g sucrose were loaded to 12 nonobese healthy male volunteers with and without 100 or 300 mg α-glucosidase inhibitor, acarbose, and the inhibitory effect on digestion and absorption of these saccharides was studied. In another series of investigations, acarbose 100 mg a day were orally administered to 12 non-insulin-dependent diabetics for 3 months together with meals. Blood glucose was determined to investigate the effect of acarbose on blood glucose control in non-insulin-dependent diabetics. In the saccharide loading tests, orally administered 300 mg acarbose did not practically inhibit absorption of 50g glucose or 50g maltose. When 50g sucrose was loaded, however, 100 or 300 mg acarbose markedly decreased absorption of this disaccharide, resulting in inhibition of increases in blood glucose and insulin. Non-insulin-dependent diabetics had significantly lower fasting blood glucose and HbA1 in 3 months of acarbose ingestion as compared with the corresponding levels in the preceding 3 months. Meteorism, increased flatulence and loose stools were complained of as adverse effects of acarbose, but they were not so serious as to require the discontinuation of medication. Acarbose might afford a safe and effective supplementary means for controlling blood glucose in diabetics. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.47.1-2.35 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/4712/4712.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 47, 号 1-2, p. 35-41, 発行日 1985-01 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/17475 | |||||
| 識別子タイプ | HDL | |||||
