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  1. C100 医学部/医学系研究科
  2. C100b 刊行物
  3. Nagoya journal of medical science
  4. 47(1-2)

Effects of Acarbose, an α-Glucosidase Inhibitor (BAY G 5421), on Orally Loaded Glucose, Maltose and Sucrose and on Blood Glucose Control in Non-Insulin-Dependent Diabetics

https://doi.org/10.18999/nagjms.47.1-2.35
https://doi.org/10.18999/nagjms.47.1-2.35
a6c2945d-c50a-4d8f-b6ee-2ca85ecff7e7
名前 / ファイル ライセンス アクション
v47n12p35_41.pdf v47n12p35_41.pdf (463.3 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-02-08
タイトル
タイトル Effects of Acarbose, an α-Glucosidase Inhibitor (BAY G 5421), on Orally Loaded Glucose, Maltose and Sucrose and on Blood Glucose Control in Non-Insulin-Dependent Diabetics
言語 en
著者 HAYAKAWA, TETUO

× HAYAKAWA, TETUO

WEKO 47086

en HAYAKAWA, TETUO

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NODA, AIJI

× NODA, AIJI

WEKO 47087

en NODA, AIJI

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KONDO, TAKAHARU

× KONDO, TAKAHARU

WEKO 47088

en KONDO, TAKAHARU

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OKUMURA, NOBUYOSHI

× OKUMURA, NOBUYOSHI

WEKO 47089

en OKUMURA, NOBUYOSHI

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 α-glucososidase inhibitor
キーワード
主題Scheme Other
主題 diabetes
キーワード
主題Scheme Other
主題 saccharides tolerance test
キーワード
主題Scheme Other
主題 insulin
キーワード
主題Scheme Other
主題 glucose
抄録
内容記述タイプ Abstract
内容記述 Fifty g glucose, 50g maltose and 50g sucrose were loaded to 12 nonobese healthy male volunteers with and without 100 or 300 mg α-glucosidase inhibitor, acarbose, and the inhibitory effect on digestion and absorption of these saccharides was studied. In another series of investigations, acarbose 100 mg a day were orally administered to 12 non-insulin-dependent diabetics for 3 months together with meals. Blood glucose was determined to investigate the effect of acarbose on blood glucose control in non-insulin-dependent diabetics. In the saccharide loading tests, orally administered 300 mg acarbose did not practically inhibit absorption of 50g glucose or 50g maltose. When 50g sucrose was loaded, however, 100 or 300 mg acarbose markedly decreased absorption of this disaccharide, resulting in inhibition of increases in blood glucose and insulin. Non-insulin-dependent diabetics had significantly lower fasting blood glucose and HbA1 in 3 months of acarbose ingestion as compared with the corresponding levels in the preceding 3 months. Meteorism, increased flatulence and loose stools were complained of as adverse effects of acarbose, but they were not so serious as to require the discontinuation of medication. Acarbose might afford a safe and effective supplementary means for controlling blood glucose in diabetics.
言語 en
出版者
出版者 Nagoya University School of Medicine
言語 en
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/nagjms.47.1-2.35
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/4712/4712.html
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ EISSN
収録物識別子 2186-3326
書誌情報 en : Nagoya Journal of Medical Science

巻 47, 号 1-2, p. 35-41, 発行日 1985-01
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/17475
識別子タイプ HDL
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