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Occurrence of a Terminal Deoxynucleotidyl Transferase-Like Activity in N-2-Fluorenylacetamide-treated Rat Liver
https://doi.org/10.18999/nagjms.47.1-2.43
https://doi.org/10.18999/nagjms.47.1-2.43792ebdec-4370-4d3c-aafa-eff75c455cad
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
v47n12p43_49.pdf (513.4 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-02-08 | |||||
| タイトル | ||||||
| タイトル | Occurrence of a Terminal Deoxynucleotidyl Transferase-Like Activity in N-2-Fluorenylacetamide-treated Rat Liver | |||||
| 言語 | en | |||||
| 著者 |
YOSHIDA, SHONEN
× YOSHIDA, SHONEN× NAKAMURA, HIROMU× KOJIMA, KIYOHIDE |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Terminal deoxynucleotidyl transferase | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Fluorenylacetamide | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Rat liver | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | DNA polymerases | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A new enzyme activity that resembles terminal deoxynucleotidyl transferase (TdT-like activity) was found in rat liver. Upon treatment of rats with a hepatocarcinogen, N-2-fluorenylacetamide, the TdT-like activity increased in parallel with DNA polymerase α and γ. By phosphocellulose column chromatography, the TdT-like activity was separated from DNA polymerase α, β, and γ. With a poly(dA)-initiator, dGTP or dCTP was the most efficient substrate in the presence of Mg^2+ or Mn^2+, respectively. In the presence of Mg^2+, the enzyme utilized poly (dC) as an initiator most efficiently. The TdT-like activity differed from previously described terminal deoxynucleotidyl transferase (E.C.2.7.7.31.) in its Km value for dGTP and in its sensitivity to ATP or to an antibody against calf thymus terminal deoxynucleotidyl transferase. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.47.1-2.43 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/4712/4712.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 47, 号 1-2, p. 43-49, 発行日 1985-01 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/17476 | |||||
| 識別子タイプ | HDL | |||||
