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Canine Pancreatic Allotransplantation with Duodenum (Pancreaticoduodenal Transplantation) Using Cyclosporin A
https://doi.org/10.18999/nagjms.47.1-2.57
https://doi.org/10.18999/nagjms.47.1-2.575335558b-bf0d-4d8f-8a4e-e4caeff6b16d
名前 / ファイル | ライセンス | アクション |
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v47n12p57_66.pdf (1.2 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2013-02-08 | |||||
タイトル | ||||||
タイトル | Canine Pancreatic Allotransplantation with Duodenum (Pancreaticoduodenal Transplantation) Using Cyclosporin A | |||||
言語 | en | |||||
著者 |
MORIMOTO, TAKESHI
× MORIMOTO, TAKESHI× TAKAGI, HIROSHI× KONDO, TATSUHEI |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pancreatic transplantation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pancreaticoduodenal transplantation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cyclosporin A | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rejection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thrombosis | |||||
抄録 | ||||||
内容記述 | Pancreatic transplantation is still partly experimental and involves a variety of problems, such as handling of exocrine secretion, prevention of arterial thrombosis of the graft, and immunosuppression. Aiming at the best method of handling exocrine secretion and at prevention of thrombosis, pancreas transplantation with the duodenum (pancreaticoduodenal transplantation) was performed in eighteen pairs of mongrel dogs. Nine recipients (control group) were transplanted without immunosuppression, and the other nine were immunosuppressed with cyclosporin A (CsA group) after transplantation. Five dogs which died of intussusception, strangulation, hemorrhagic pancreatities etc. were not evaluated in this study. In the control group, survivals were 16, 14, 8, 7 and 6 days; in the CsA group, survivals were >395, >150, 89, 70, 25, 18, 18, and 12 days, respectively. In the CsA group there were two long-term surviving dogs without rejection; and the grafted pancreas of one of these dogs was judged to be almost normal in exocrine and endocrine glands microscopically from a specimen biopsied on the 260th postoperative day. This result is worthy of special mention in the animal experiment. CsA was more effective in prolonging survival of the dogs which received pancreaticoduodenal transplantation when compared with conventional immunosuppression. In the pancreaticoduodenal transplantation with aortic cuff, which was expected to increase the blood flow of the graft followed by a decrease in the incidence of thrombosis, there were 6 cases with thrombosis of the graft among 13 recipients. It was concluded, therefore, that CsA is effective in prolonging the survival of dogs which receive pancreaticoduodenal transplantation with physiological drainage of exocrine secretion into the duodenum, but that prevention of thrombosis by means of adequate anti-thrombosis treatment is essential. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.47.1-2.57 | |||||
ID登録タイプ | JaLC | |||||
関連情報 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/4712/4712.html | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 47, 号 1-2, p. 57-66, 発行日 1985-01 |
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著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/17478 | |||||
識別子タイプ | HDL |