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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 49(1-4)

Role of Sympathoadrenal and Renin-Angiotensin System in Hemodynamic State after Coronary Artery Bypass Grafting

https://doi.org/10.18999/nagjms.49.1-4.1
https://doi.org/10.18999/nagjms.49.1-4.1
baf4b8ef-f103-4d69-8a93-12d85d052e2e
名前 / ファイル ライセンス アクション
v49n14p1_15.pdf v49n14p1_15.pdf (954.5 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-02-13
タイトル
タイトル Role of Sympathoadrenal and Renin-Angiotensin System in Hemodynamic State after Coronary Artery Bypass Grafting
著者 HAYASE, SHOOHEI

× HAYASE, SHOOHEI

WEKO 47159

HAYASE, SHOOHEI

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SHIMIZU, TAKESHI

× SHIMIZU, TAKESHI

WEKO 47160

SHIMIZU, TAKESHI

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NAKAJIMA, MASAMICHI

× NAKAJIMA, MASAMICHI

WEKO 47161

NAKAJIMA, MASAMICHI

Search repository
キーワード
主題Scheme Other
主題 Coronary artery bypass grafting
キーワード
主題Scheme Other
主題 Renin-angiotensin system
キーワード
主題Scheme Other
主題 Sympathoadrenal system
キーワード
主題Scheme Other
主題 Hypertension
キーワード
主題Scheme Other
主題 Perioperative myocardial infarction
抄録
内容記述 To evaluate the role of the sympathoadrenal and renin-angiotensin systems in postoperative hemodynamic state, plasma concentrations of catecholamines, renin activity, angiotensin, and aldosterone as well as hemodynamics were studied following coronary artery bypass grafting in 55 patients. The patients were divided into four groups: 1) uneventful, 2) hypertension (HT), 3) hypotension for which cateeholamines were administered (CAT), and 4) perioperative myocardial infarction (POMI). The mean cardiac index in the HT group was higher than that in the Uneventful group and some patients in the HT group showed high adrenaline level. A group of patients who had a hypertensive episode and then sustained low cardiac output state (HT-to-LOS group) showed marked elevation of systemic vascular resistance index and noradrenaline level. These findings suggest that the hypertensive episodes in the HT-to-LOS group may be primarily caused by the activation of the sympathetic nerve system and that those of some patients in the HT group may be caused by marked adrenal medullary secretion. Five patients (56%) in the HT group showed plasma renin activity of more than 5.0 ng/ml/hr, and three patients (33%) showed angiotensin II of more than 100 pg/ml. Thus, postoperative hypertension seems to be multifactorial in nature. The POMI group represented significant elevation of plasma adrenaline concentration and significantly low sensitivity to catecholamines of the ventricle accompanied with impaired left ventricular performance. Although the mean aldosterone level in the CAT group was significantly higher than that in the Uneventful group, only a few patients of the CAT group demonstrated marked elevation of aldosterone concentration which might cause a vicious circle to develop. Clinical significance of modest increase of aldosterone concentration in other patients in the CAT group is questionable.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.49.1-4.1
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 49, 号 1-4, p. 1-15, 発行日 1987-03
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/4914/4914.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/17493
識別子タイプ HDL
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