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The Relationship between Insulin Sensitivity and Weight Reduction in Simple Obese and Obese Diabetic Patients
https://doi.org/10.18999/nagjms.49.1-4.61
https://doi.org/10.18999/nagjms.49.1-4.6191c2cd40-a9d2-4d41-b4e0-cb5e4da8d682
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
v49n14p61_69.pdf (541.2 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-02-13 | |||||
| タイトル | ||||||
| タイトル | The Relationship between Insulin Sensitivity and Weight Reduction in Simple Obese and Obese Diabetic Patients | |||||
| 言語 | en | |||||
| 著者 |
ISHIGURO, TETSUYA
× ISHIGURO, TETSUYA× SATO, YUZO× OSHIDA, YOSHIHARU× YAMANOUCHI, KUNIO× OKUYAMA, MAKIO× SAKAMOTO, NOBUO |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | simple obese subjects | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | obese diabetic patients | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | insulin sensitivity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | euglycemic insulin clamp technique | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | physical exercise | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Tissue sensitivity to exogenous insulin was determined in 10 obese diabetic patients, in 15 patients with simple obesity, and in 28 non-obese controls. Eight of the obese diabetics and five of the patients with simple obesity underwent dietary restriction (1,000-1,600 kcal/day) and physical training for eight weeks. Insulin sensitivity was evaluated by the euglycemic insulin clamp technique for 120 min. The amount of infused glucose (glucose mctabolism: GM) is a measure of the overall tissue sensitivity to insulin. Differences in fasting blood glucose levels were adjusted by calculation of the glucose metabolic clearance rate (MCR). GM and MCR in the obese diabetics and in the patients with simple obesity were significantly (P<0.001) lower than in the controls. Inverse correlations existed between BMI and GM, between BMI and MCR, and also between fasting plasma insulin levels and both GM and MCR, respectively. After physical training, significant weight reduction was obtained, while MCR increased from 2.70 ± 0.26 ml/kg/min to 5.47 ± 0.88 ml/kg/min. Further significant correlation existed between reduction of BMI and increases in insulin sensitivity (GM and MCR). These results suggest that a combined program of physical training with caloric restriction would decrease body weight and increase peripheral insulin sensitivity, and would therefore be especially appropriate for the treatment of simple obese and obese diabetic patients. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.49.1-4.61 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/4914/4914.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 49, 号 1-4, p. 61-69, 発行日 1987-03 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/17499 | |||||
| 識別子タイプ | HDL | |||||
