ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "22c59dbd-d7ab-4693-8c61-62a20e43d4d6"}, "_deposit": {"id": "15488", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "15488"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00015488", "sets": ["1462"]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1989-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1-4", "bibliographicPageEnd": "16", "bibliographicPageStart": "7", "bibliographicVolumeNumber": "51", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science"}]}]}, "item_9_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The present study investigated whether or not, in addition to the oral glucose tolerance test, oral alanine loading was a useful diagnostic tool for hormonal and metabolic diseases. Fifty g of L-alanine was administered orally in 14 normal, 12 diabetic, and 8 liver cirrhotic subjects. The influence of oral alanine loading on hormones and metabolites was compared with the results of 100g oral glucose loading. The results obtained were as follows: 1) In the normal subjects and cirrhotics, lactate and pyruvate concentrations gradually increased with time and reached their peak levels at 60 min, whereas they remained unchanged throughout the course in the diabetic group at glucose loading. 2) Alanine administration accelerated ureogenesis but did not affect blood glucose levels. 3) In both glucose and L-alanine administration, free fatty acid, glycerol and ketone body levels declined nonspecifically in all groups. 4) Serum glucagon levels during L-alanine loading increased in all groups, especially in liver cirrhotics. 5) L-alanine was a potent stimulus for insulin secretion in diabetics, while no insulin release during glucose loading was observed. 6) The molar ratio of insulin levels (during glucose loading)/glucagon levels (during L-alanine loading) was a good indicator of systemic glucose homeostasis from the hormonal aspect. It is suggested that, in addition to the oral glucose tolerance test, the oral administration of L-alanine can be a useful tool for the diagnosis of the status in diabetes mellitus and cirrhosis.", "subitem_description_type": "Abstract"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "URI", "subitem_identifier_uri": "http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5114/5114.html"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/17506"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.51.1-4.7", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University School of Medicine"}]}, "item_9_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_61": {"attribute_name": "ISSN(Online)", "attribute_value_mlt": [{"subitem_source_identifier": "2186-3326", "subitem_source_identifier_type": "ISSN"}]}, "item_9_source_id_7": {"attribute_name": "ISSN(print)", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "HATTORI, TADAKAZU"}], "nameIdentifiers": [{"nameIdentifier": "47214", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "HOTTA, NIGISHI"}], "nameIdentifiers": [{"nameIdentifier": "47215", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "OHARA, KIYOJI"}], "nameIdentifiers": [{"nameIdentifier": "47216", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SHINODA, HIROSHI"}], "nameIdentifiers": [{"nameIdentifier": "47217", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KUNIEDA, TAKEHIDE"}], "nameIdentifiers": [{"nameIdentifier": "47218", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "NOMURA, TAKAHIDE"}], "nameIdentifiers": [{"nameIdentifier": "47219", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KAKUTA, HIRONOBU"}], "nameIdentifiers": [{"nameIdentifier": "47220", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TAMAGAWA, TATSUO"}], "nameIdentifiers": [{"nameIdentifier": "47221", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SAKAMOTO, NOBUO"}], "nameIdentifiers": [{"nameIdentifier": "47222", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "v51n14p7_16.pdf", "filesize": [{"value": "724.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 724700.0, "url": {"label": "v51n14p7_16.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/15488/files/v51n14p7_16.pdf"}, "version_id": "ebcaf263-124b-418b-b34d-ca5bbecc8677"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "L-Alanine oral loading", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Lactate", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Glucagon", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Molar ratio of insulin/glucagon", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Pancreatic α- and β-Cell Function and Metabolic Changes during Oral L-Alanine and Glucose Administration: Comparative Studies between Normal, Diabetic and Cirrhotic Subjects", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Pancreatic α- and β-Cell Function and Metabolic Changes during Oral L-Alanine and Glucose Administration: Comparative Studies between Normal, Diabetic and Cirrhotic Subjects"}]}, "item_type_id": "9", "owner": "1", "path": ["1462"], "permalink_uri": "https://doi.org/10.18999/nagjms.51.1-4.7", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-02-13"}, "publish_date": "2013-02-13", "publish_status": "0", "recid": "15488", "relation": {}, "relation_version_is_last": true, "title": ["Pancreatic α- and β-Cell Function and Metabolic Changes during Oral L-Alanine and Glucose Administration: Comparative Studies between Normal, Diabetic and Cirrhotic Subjects"], "weko_shared_id": 3}
  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 51(1-4)

Pancreatic α- and β-Cell Function and Metabolic Changes during Oral L-Alanine and Glucose Administration: Comparative Studies between Normal, Diabetic and Cirrhotic Subjects

https://doi.org/10.18999/nagjms.51.1-4.7
https://doi.org/10.18999/nagjms.51.1-4.7
409d3c2e-a3c8-4736-817f-7cb47e6766ff
名前 / ファイル ライセンス アクション
v51n14p7_16.pdf v51n14p7_16.pdf (724.7 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-02-13
タイトル
タイトル Pancreatic α- and β-Cell Function and Metabolic Changes during Oral L-Alanine and Glucose Administration: Comparative Studies between Normal, Diabetic and Cirrhotic Subjects
著者 HATTORI, TADAKAZU

× HATTORI, TADAKAZU

WEKO 47214

HATTORI, TADAKAZU

Search repository
HOTTA, NIGISHI

× HOTTA, NIGISHI

WEKO 47215

HOTTA, NIGISHI

Search repository
OHARA, KIYOJI

× OHARA, KIYOJI

WEKO 47216

OHARA, KIYOJI

Search repository
SHINODA, HIROSHI

× SHINODA, HIROSHI

WEKO 47217

SHINODA, HIROSHI

Search repository
KUNIEDA, TAKEHIDE

× KUNIEDA, TAKEHIDE

WEKO 47218

KUNIEDA, TAKEHIDE

Search repository
NOMURA, TAKAHIDE

× NOMURA, TAKAHIDE

WEKO 47219

NOMURA, TAKAHIDE

Search repository
KAKUTA, HIRONOBU

× KAKUTA, HIRONOBU

WEKO 47220

KAKUTA, HIRONOBU

Search repository
TAMAGAWA, TATSUO

× TAMAGAWA, TATSUO

WEKO 47221

TAMAGAWA, TATSUO

Search repository
SAKAMOTO, NOBUO

× SAKAMOTO, NOBUO

WEKO 47222

SAKAMOTO, NOBUO

Search repository
キーワード
主題Scheme Other
主題 L-Alanine oral loading
キーワード
主題Scheme Other
主題 Lactate
キーワード
主題Scheme Other
主題 Glucagon
キーワード
主題Scheme Other
主題 Molar ratio of insulin/glucagon
抄録
内容記述 The present study investigated whether or not, in addition to the oral glucose tolerance test, oral alanine loading was a useful diagnostic tool for hormonal and metabolic diseases. Fifty g of L-alanine was administered orally in 14 normal, 12 diabetic, and 8 liver cirrhotic subjects. The influence of oral alanine loading on hormones and metabolites was compared with the results of 100g oral glucose loading. The results obtained were as follows: 1) In the normal subjects and cirrhotics, lactate and pyruvate concentrations gradually increased with time and reached their peak levels at 60 min, whereas they remained unchanged throughout the course in the diabetic group at glucose loading. 2) Alanine administration accelerated ureogenesis but did not affect blood glucose levels. 3) In both glucose and L-alanine administration, free fatty acid, glycerol and ketone body levels declined nonspecifically in all groups. 4) Serum glucagon levels during L-alanine loading increased in all groups, especially in liver cirrhotics. 5) L-alanine was a potent stimulus for insulin secretion in diabetics, while no insulin release during glucose loading was observed. 6) The molar ratio of insulin levels (during glucose loading)/glucagon levels (during L-alanine loading) was a good indicator of systemic glucose homeostasis from the hormonal aspect. It is suggested that, in addition to the oral glucose tolerance test, the oral administration of L-alanine can be a useful tool for the diagnosis of the status in diabetes mellitus and cirrhosis.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.51.1-4.7
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 51, 号 1-4, p. 7-16, 発行日 1989-03
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5114/5114.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/17506
識別子タイプ HDL
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 09:13:50.103602
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3