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Serum Deoxythymidine Kinase as a Progressive Marker of Hematological Malignancy
https://doi.org/10.18999/nagjms.52.1-4.19
https://doi.org/10.18999/nagjms.52.1-4.194d2d2ceb-4c25-452a-b54c-6960bcc8448d
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2013-02-14 | |||||
タイトル | ||||||
タイトル | Serum Deoxythymidine Kinase as a Progressive Marker of Hematological Malignancy | |||||
著者 |
DOI, SATORU
× DOI, SATORU× NAITO, KAZUYUKI× YAMADA, KAZUMASA |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | Serum deoxythymidine kinase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hematological malignancy | |||||
抄録 | ||||||
内容記述 | The levels of serum deoxythymidine kinase (s-dTK) were investigated for 127 patients suffering hematological malignancy by a sensitive method using [125I]-iododeoxy-uridine as substrate. It was found that the deoxythymidine kinase activity in the sera of these patients was higher than the normal levels in adults. It was also found that the levels of s-dTK in the progressive stage were much higher than those in the indolent stage. These results suggest that high levels of s-dTK in hematological malignancy may reflect the extent of disease and that this activity may be derived from proliferating leukemic cells. The deoxythymidine kinase activity in the extracts derived from cultured cell lines and clinical specimens indicated that leukemic cells contained much higher activity than normal cells. | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.52.1-4.19 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
Nagoya Journal of Medical Science 巻 52, 号 1-4, p. 19-26, 発行日 1990-03 |
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著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5214/5214.html | |||||
識別子タイプ | URI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/17512 | |||||
識別子タイプ | HDL |