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Intrahepatocellular Localization of Copper in Wilson's Disease
https://doi.org/10.18999/nagjms.55.1-4.131
https://doi.org/10.18999/nagjms.55.1-4.13115a81945-f6ff-4202-a95a-d1f6b8d7d038
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
v55n14p131_137.pdf (781.4 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-02-18 | |||||
| タイトル | ||||||
| タイトル | Intrahepatocellular Localization of Copper in Wilson's Disease | |||||
| 言語 | en | |||||
| 著者 |
YANO, MOTOYOSHI
× YANO, MOTOYOSHI× SAKAMOTO, NOBUO× TAKIKAWA, TOSHIKUNI× HAYASHI, HISAO |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Wilson's disease | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Copper | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Hepatocytes | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Nucleus | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cytoplasm | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | X-ray analysis | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | It is well known that excess copper plays a role in the pathogenesis of Wilson's disease; however, the hepatic copper contents, determined either histochemically or biochemically, are not always correlated with the activity of Wilson's disease. To better understand copper-induced cytotoxicity, intrahepatocellular localization of copper was studied in five patients with Wilson's disease. The liver specimens were obtained by biopsy to confirm the clinical diagnosis of Wilson's disease before treatment. Neither hepatic copper content nor histochemical copper deposits were correlated with any of the biochemical indices studied. Energy-dispersion X-ray microanalysis was done on the nuclei, lysosomes and lysosome-free cytoplasm of hepatocytes. Lysosomes had the highest Cu X-ray intensity but no correlation was shown between the lysosomal copper content and biochemical indices. The nucleus/lysosome-free cytoplasm ratio of the copper content was correlated with the serum levels of aminotransferases. These results suggest that the copper increasing gradient from the lysosome-free cytoplasm to the nucleus is associated with hepatocyte necrosis, and probably causes irreversible nuclear damage. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.55.1-4.131 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5514/5514.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 55, 号 1-4, p. 131-137, 発行日 1993-03 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
