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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 75(1-2)

DPP4 Genetic Variants Influence Baseline Prostate-Specific Antigen Levels: The J-MICC Study

https://doi.org/10.18999/nagjms.75.1-2.73
https://doi.org/10.18999/nagjms.75.1-2.73
50df99c6-8588-42b0-9100-362dec6d4145
名前 / ファイル ライセンス アクション
08_Higashibata.pdf 08_Higashibata.pdf (121.8 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-03-01
タイトル
タイトル DPP4 Genetic Variants Influence Baseline Prostate-Specific Antigen Levels: The J-MICC Study
著者 HIGASHIBATA, TAKAHIRO

× HIGASHIBATA, TAKAHIRO

WEKO 47460

HIGASHIBATA, TAKAHIRO

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NAITO, MARIKO

× NAITO, MARIKO

WEKO 47461

NAITO, MARIKO

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MORI, ATSUYOSHI

× MORI, ATSUYOSHI

WEKO 47462

MORI, ATSUYOSHI

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OZAWA, NORIYO

× OZAWA, NORIYO

WEKO 47463

OZAWA, NORIYO

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FURUTA, MASATOSHI

× FURUTA, MASATOSHI

WEKO 47464

FURUTA, MASATOSHI

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TSUCHIYA, RUMI

× TSUCHIYA, RUMI

WEKO 47465

TSUCHIYA, RUMI

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KOYAMA, ERINA

× KOYAMA, ERINA

WEKO 47466

KOYAMA, ERINA

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MORITA, EMI

× MORITA, EMI

WEKO 47467

MORITA, EMI

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KAWAI, SAYO

× KAWAI, SAYO

WEKO 47468

KAWAI, SAYO

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OKADA, RIEKO

× OKADA, RIEKO

WEKO 47469

OKADA, RIEKO

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YIN, GUANG

× YIN, GUANG

WEKO 47470

YIN, GUANG

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WAKAI, KENJI

× WAKAI, KENJI

WEKO 47471

WAKAI, KENJI

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HAMAJIMA, NOBUYUKI

× HAMAJIMA, NOBUYUKI

WEKO 47472

HAMAJIMA, NOBUYUKI

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キーワード
主題Scheme Other
主題 DPP-IV
キーワード
主題Scheme Other
主題 Prostate cancer
キーワード
主題Scheme Other
主題 Screening
キーワード
主題Scheme Other
主題 Polymorphism
キーワード
主題Scheme Other
主題 Cross-sectional study
抄録
内容記述 Prostate specific antigen (PSA) testing plays a major role in prostate cancer screening; however, the low positive predictive value of PSA testing leads to many unnecessary biopsies. Genetic background is one of factors that could cause it. That’s why an association between genetic background and PSA levels should be elucidated. This study aimed to investigate whether DPP4 genetic variants are associated with baseline PSA levels. A cross-sectional study was performed on 2,074 Japanese men aged between 35 and 69 in the Shizuoka area from the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. Three DPP4 tagging single nucleotide polymorphisms (SNPs) were selected for genotyping: rs3788979 (A/G), rs7608798 (T/C), and rs2268889 (A/G). Higher mean serum PSA levels were significantly associated with an increase in the number of the rs7608798 C allele (p for trend = 0.02). A stratified analysis by age groups demonstrated that PSA levels had positive significant trends with the numbers of the minor alleles of rs3788979 or rs7608798 in the oldest group (men aged between 60 and 69) (p for trend=0.004 for rs3788979 and p for trend=0.001 for rs7608798). Haplotype analysis showed that the C-A (rs7608798- rs2268889) haplotype was significantly associated with increased PSA levels (p=0.006), compared with the most common haplotype, T-A. In summary, our study suggests that DPP4 genetic variants influence baseline PSA levels, especially in men aged between 60 and 69.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.75.1-2.73
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 75, 号 1-2, p. 73-80, 発行日 2013-02
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7512/7512.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/17603
識別子タイプ HDL
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