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DPP4 Genetic Variants Influence Baseline Prostate-Specific Antigen Levels: The J-MICC Study
https://doi.org/10.18999/nagjms.75.1-2.73
https://doi.org/10.18999/nagjms.75.1-2.7350df99c6-8588-42b0-9100-362dec6d4145
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
08_Higashibata.pdf (121.8 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-03-01 | |||||
| タイトル | ||||||
| タイトル | DPP4 Genetic Variants Influence Baseline Prostate-Specific Antigen Levels: The J-MICC Study | |||||
| 言語 | en | |||||
| 著者 |
HIGASHIBATA, TAKAHIRO
× HIGASHIBATA, TAKAHIRO× NAITO, MARIKO× MORI, ATSUYOSHI× OZAWA, NORIYO× FURUTA, MASATOSHI× TSUCHIYA, RUMI× KOYAMA, ERINA× MORITA, EMI× KAWAI, SAYO× OKADA, RIEKO× YIN, GUANG× WAKAI, KENJI× HAMAJIMA, NOBUYUKI |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | DPP-IV | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Prostate cancer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Screening | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Polymorphism | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cross-sectional study | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Prostate specific antigen (PSA) testing plays a major role in prostate cancer screening; however, the low positive predictive value of PSA testing leads to many unnecessary biopsies. Genetic background is one of factors that could cause it. That’s why an association between genetic background and PSA levels should be elucidated. This study aimed to investigate whether DPP4 genetic variants are associated with baseline PSA levels. A cross-sectional study was performed on 2,074 Japanese men aged between 35 and 69 in the Shizuoka area from the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. Three DPP4 tagging single nucleotide polymorphisms (SNPs) were selected for genotyping: rs3788979 (A/G), rs7608798 (T/C), and rs2268889 (A/G). Higher mean serum PSA levels were significantly associated with an increase in the number of the rs7608798 C allele (p for trend = 0.02). A stratified analysis by age groups demonstrated that PSA levels had positive significant trends with the numbers of the minor alleles of rs3788979 or rs7608798 in the oldest group (men aged between 60 and 69) (p for trend=0.004 for rs3788979 and p for trend=0.001 for rs7608798). Haplotype analysis showed that the C-A (rs7608798- rs2268889) haplotype was significantly associated with increased PSA levels (p=0.006), compared with the most common haplotype, T-A. In summary, our study suggests that DPP4 genetic variants influence baseline PSA levels, especially in men aged between 60 and 69. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.75.1-2.73 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7512/7512.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 75, 号 1-2, p. 73-80, 発行日 2013-02 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/17603 | |||||
| 識別子タイプ | HDL | |||||
