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Glucocorticoid-Induced Hypertension and Cardiac Injury: Effects of Mineralocorticoid and Glucocorticoid Receptor Antagonism
https://doi.org/10.18999/nagjms.75.1-2.81
https://doi.org/10.18999/nagjms.75.1-2.81ff9f252a-76e5-49d4-a447-95beb5fac19d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
09_Nagata.pdf (15.3 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-03-01 | |||||
| タイトル | ||||||
| タイトル | Glucocorticoid-Induced Hypertension and Cardiac Injury: Effects of Mineralocorticoid and Glucocorticoid Receptor Antagonism | |||||
| 言語 | en | |||||
| 著者 |
HATTORI, TAKUYA
× HATTORI, TAKUYA× MURASE, TAMAYO× IWASE, ERIKA× TAKAHASHI, KEIJI× OHTAKE, MASAFUMI× TSUBOI, KOJI× OHTAKE, MAYUKO× MIYACHI, MASAAKI× MUROHARA, TOYOAKI× NAGATA, KOHZO |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | glucocorticoids | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hypertension | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cardiac atrophy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | diastolic dysfunction | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Glucocorticoids are widely administered for the treatment of various disorders, although their long-term use results in adverse effects associated with glucocorticoid excess. We investigated the pathophysiological roles of glucocorticoid receptors (GRs) and mineralocorticoid receptors (MRs) in the cardiac changes induced by exogenous corticosterone in rats. Corticosterone or vehicle was injected twice daily in rats from 8 to 12 weeks of age. The effects of the GR antagonist RU 486, the MR antagonist spironolactone, or both agents on corticosterone action were also determined. Corticosterone induced hypertension, left ventricular (LV) fibrosis, and LV diastolic dysfunction. Neither RU 486 nor spironolactone affected corticosteroneinduced hypertension, whereas spironolactone, but not RU 486, attenuated the effects of corticosterone on LV fibrosis and diastolic function. Corticosterone also increased cardiac oxidative stress and inflammation in a manner sensitive to spironolactone but not to RU 486. The corticosterone-induced LV atrophy was not affected by either RU 486 or spironolactone. Our results implicate MRs in the cardiac fibrosis and diastolic dysfunction, but not MRs or GRs in the cardiac atrophy, induced by corticosterone. Neither MRs nor GRs appear to contribute to corticosterone-induced hypertension. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.75.1-2.81 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7512/7512.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 75, 号 1-2, p. 81-92, 発行日 2013-02 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/17604 | |||||
| 識別子タイプ | HDL | |||||
