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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 75(1-2)

Glucocorticoid-Induced Hypertension and Cardiac Injury: Effects of Mineralocorticoid and Glucocorticoid Receptor Antagonism

https://doi.org/10.18999/nagjms.75.1-2.81
https://doi.org/10.18999/nagjms.75.1-2.81
ff9f252a-76e5-49d4-a447-95beb5fac19d
名前 / ファイル ライセンス アクション
09_Nagata.pdf 09_Nagata.pdf (15.3 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-03-01
タイトル
タイトル Glucocorticoid-Induced Hypertension and Cardiac Injury: Effects of Mineralocorticoid and Glucocorticoid Receptor Antagonism
著者 HATTORI, TAKUYA

× HATTORI, TAKUYA

WEKO 47473

HATTORI, TAKUYA

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MURASE, TAMAYO

× MURASE, TAMAYO

WEKO 47474

MURASE, TAMAYO

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IWASE, ERIKA

× IWASE, ERIKA

WEKO 47475

IWASE, ERIKA

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TAKAHASHI, KEIJI

× TAKAHASHI, KEIJI

WEKO 47476

TAKAHASHI, KEIJI

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OHTAKE, MASAFUMI

× OHTAKE, MASAFUMI

WEKO 47477

OHTAKE, MASAFUMI

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TSUBOI, KOJI

× TSUBOI, KOJI

WEKO 47478

TSUBOI, KOJI

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OHTAKE, MAYUKO

× OHTAKE, MAYUKO

WEKO 47479

OHTAKE, MAYUKO

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MIYACHI, MASAAKI

× MIYACHI, MASAAKI

WEKO 47480

MIYACHI, MASAAKI

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MUROHARA, TOYOAKI

× MUROHARA, TOYOAKI

WEKO 47481

MUROHARA, TOYOAKI

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NAGATA, KOHZO

× NAGATA, KOHZO

WEKO 47482

NAGATA, KOHZO

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キーワード
主題Scheme Other
主題 glucocorticoids
キーワード
主題Scheme Other
主題 hypertension
キーワード
主題Scheme Other
主題 cardiac atrophy
キーワード
主題Scheme Other
主題 diastolic dysfunction
抄録
内容記述 Glucocorticoids are widely administered for the treatment of various disorders, although their long-term use results in adverse effects associated with glucocorticoid excess. We investigated the pathophysiological roles of glucocorticoid receptors (GRs) and mineralocorticoid receptors (MRs) in the cardiac changes induced by exogenous corticosterone in rats. Corticosterone or vehicle was injected twice daily in rats from 8 to 12 weeks of age. The effects of the GR antagonist RU 486, the MR antagonist spironolactone, or both agents on corticosterone action were also determined. Corticosterone induced hypertension, left ventricular (LV) fibrosis, and LV diastolic dysfunction. Neither RU 486 nor spironolactone affected corticosteroneinduced hypertension, whereas spironolactone, but not RU 486, attenuated the effects of corticosterone on LV fibrosis and diastolic function. Corticosterone also increased cardiac oxidative stress and inflammation in a manner sensitive to spironolactone but not to RU 486. The corticosterone-induced LV atrophy was not affected by either RU 486 or spironolactone. Our results implicate MRs in the cardiac fibrosis and diastolic dysfunction, but not MRs or GRs in the cardiac atrophy, induced by corticosterone. Neither MRs nor GRs appear to contribute to corticosterone-induced hypertension.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.75.1-2.81
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 75, 号 1-2, p. 81-92, 発行日 2013-02
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7512/7512.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/17604
識別子タイプ HDL
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