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Pituitary-Adrenocortical Response after Craniotomy for Brain Tumor, and Its Suppression with Administered Glucocorticoid
https://doi.org/10.18999/nagjms.30.1.69
https://doi.org/10.18999/nagjms.30.1.69fd40f599-47ab-462a-9ff4-ad15e4717980
名前 / ファイル | ライセンス | アクション |
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v30n1p69_97.pdf (3.8 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2013-09-25 | |||||
タイトル | ||||||
タイトル | Pituitary-Adrenocortical Response after Craniotomy for Brain Tumor, and Its Suppression with Administered Glucocorticoid | |||||
言語 | en | |||||
著者 |
NAKAMURA, KOJI
× NAKAMURA, KOJI |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述 | Nowadays large doses of glucocorticoids are administered to prevent cerebral edema during and after craniotomy for brain tumor. The influence of this glucocorticoids therapy on the hypothalamo-pituitary-adrenocortical response was studied clinically. Urinary total 17-hydroxycorticoids excretion (17-OH-CH) was estimated. Preoperative basal level of 17-OH-CS in brain tumor cases was lower than normal basal level except in some cases in which rapid increase in intracranial hypertension was the main sign. Adrenocortical response was more intense in brain tumor craniotomy than in other operations such as lumbar sympathectomy for Buerger's disease or craniotomy for various diseases of the brain and skull other than brain tumor. Large doses of dexamethasone administered prophylactically to prevent cerebral edema, suppressed significantly this intense response to brain tumor craniotomy. It was reduced to a degree equal to adrenocortical response to operations of control cases. In most cases suppression with dexamethasone in craniotomy was correlated to preoperative suppression test with dexamethasone, suggesting that the same mechanism might play in both resting and stressful conditions. More than four weeks after the operation, influence of this prophylactic dexamethasone therapy was tested; the suppression test was made and found to be within normal limit. Glucocorticoids therapy to prevent cerebral edema is supported from this point of view, for the adrenocortical reserve may be maintained even during and after craniotomy. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.30.1.69 | |||||
ID登録タイプ | JaLC | |||||
関連情報 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/301/301.html | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 30, 号 1, p. 69-97, 発行日 1967-06 |
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著者版フラグ | ||||||
値 | publisher |