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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 30(1)

Pituitary-Adrenocortical Response after Craniotomy for Brain Tumor, and Its Suppression with Administered Glucocorticoid

https://doi.org/10.18999/nagjms.30.1.69
https://doi.org/10.18999/nagjms.30.1.69
fd40f599-47ab-462a-9ff4-ad15e4717980
名前 / ファイル ライセンス アクション
v30n1p69_97.pdf v30n1p69_97.pdf (3.8 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-09-25
タイトル
タイトル Pituitary-Adrenocortical Response after Craniotomy for Brain Tumor, and Its Suppression with Administered Glucocorticoid
著者 NAKAMURA, KOJI

× NAKAMURA, KOJI

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NAKAMURA, KOJI

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抄録
内容記述 Nowadays large doses of glucocorticoids are administered to prevent cerebral edema during and after craniotomy for brain tumor. The influence of this glucocorticoids therapy on the hypothalamo-pituitary-adrenocortical response was studied clinically. Urinary total 17-hydroxycorticoids excretion (17-OH-CH) was estimated. Preoperative basal level of 17-OH-CS in brain tumor cases was lower than normal basal level except in some cases in which rapid increase in intracranial hypertension was the main sign. Adrenocortical response was more intense in brain tumor craniotomy than in other operations such as lumbar sympathectomy for Buerger's disease or craniotomy for various diseases of the brain and skull other than brain tumor. Large doses of dexamethasone administered prophylactically to prevent cerebral edema, suppressed significantly this intense response to brain tumor craniotomy. It was reduced to a degree equal to adrenocortical response to operations of control cases. In most cases suppression with dexamethasone in craniotomy was correlated to preoperative suppression test with dexamethasone, suggesting that the same mechanism might play in both resting and stressful conditions. More than four weeks after the operation, influence of this prophylactic dexamethasone therapy was tested; the suppression test was made and found to be within normal limit. Glucocorticoids therapy to prevent cerebral edema is supported from this point of view, for the adrenocortical reserve may be maintained even during and after craniotomy.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.30.1.69
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/301/301.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 30, 号 1, p. 69-97, 発行日 1967-06
著者版フラグ
値 publisher
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