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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 32(1)

Studies on the Variation of Serum Sialic Acid and Hexosamine Contents in the Sprague-Dawley Rats with The Experimental Bone Tumor

https://doi.org/10.18999/nagjms.32.1.23
https://doi.org/10.18999/nagjms.32.1.23
f72b2402-6621-4185-a02b-7dec4bb81a7a
名前 / ファイル ライセンス アクション
v32n1p23_43.pdf v32n1p23_43.pdf (3.6 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-10-03
タイトル
タイトル Studies on the Variation of Serum Sialic Acid and Hexosamine Contents in the Sprague-Dawley Rats with The Experimental Bone Tumor
著者 KAJINO, GAKUJI

× KAJINO, GAKUJI

WEKO 96847

KAJINO, GAKUJI

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抄録
内容記述 Variations of serum sialic acid and total hexosamine (glucosamine and galactosamine) levels were investigated in rats of the Sprague-Dawley strain for clarification as follows: (1) Physiological variations of these levels by age in normal rats. (2) Variations of these levels during the growth of tumor after intramedullar implantation of Walker carcinosarcoma 256; relationship between these values and treatments; and the changes of these values according to the relapse and/or metastasis in the treated rats. As a result, the values of serum sialic acid and of total hexosamine showed a tendency of gradual increase by age. Serum sialic acid and total hexosamine levels and ratio of glucosamine to galactosamine showed significant increase with the growth of the implanted tumor. After treatments these values returned to normal ranges, but these values were elevated again when recurrence and/or metastasis occurred. Therefore, it may be valuable in observing the response to therapy and in prognosis, to determine these values. There were positive correlation coefficients between the wet weight of tumor masses transplanted subcutaneously and the serum levels of sialic acid and also between the levels of serum siaiic acid and total hexosamine in this study. The high contents of total hexosamine were caused to a large extent by the changes of glucosamine contents and to a less extent by the changes of galactosamine levels. Galactosamine, which was found much more than glucosamine in bony tissues, was not released into blood by lesions of the bone substrate.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.32.1.23
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/321/321.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 32, 号 1, p. 23-43, 発行日 1969-07
著者版フラグ
値 publisher
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