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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 32(2)

SH Compounds and Atherosclerosis

https://doi.org/10.18999/nagjms.32.2.281
https://doi.org/10.18999/nagjms.32.2.281
a368f709-f767-4737-8cdf-c2f03dfef52a
名前 / ファイル ライセンス アクション
v32n2p281_302.pdf v32n2p281_302.pdf (3.0 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-10-04
タイトル
タイトル SH Compounds and Atherosclerosis
著者 TAKAGI, YUKIO

× TAKAGI, YUKIO

WEKO 98571

TAKAGI, YUKIO

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抄録
内容記述 Fatty acid peroxides have been found in the atherosclerotic human aorta. Glavind found a correlation between the extent of the atherosclerotic changes and the content of lipid peroxides. These lipid peroxides are very toxic to the tissues. There are several compounds in the tissues to counteract the toxicity of peroxides in vivo, i.e. SH compounds, ascorbic acid, or tocopherol. · It may be inferred that an increase of peroxides and a decrease of SH compounds occur in the experimental atherosclerotic aorta and that the administration of such reducing substances as ascorbic acid or SH compounds reactivates the respiration of the aorta inhibited by peroxides and retards the atherogenesis. It may be also supposed that a decrease of SH compounds occurs in the human atherosclerotic aorta. From these considerations the present investigations were performed. In the rabbits fed cholesterol, a decrease of nonprotein SH content and an increase of TEA reactive substances were observed in the aorta at the stage when the reduction of respiratory activity was not revealed. Furthermore, a decrease of total SH content was observed· in the serum, while total SH, nonprotein SH contents and SDH activity were normal in the liver. In the rabbits fed cholesterol with concomitant administration of ascorbic acid or SH compounds, the grade of atherosclerosis and the abnormality of total cholesterol and total SH contents were improved. The development of atherosclerosis was retarded as compared with the control, while the abnormality of lipids in quantity and of fatty acid composition was not improved. Nonprotein SH content in the human atherosclerotic abdominal aorta decreased as compared with the normal aorta. From these results, it may be concluded on atherogenesis that a damage of protein induced by nonenzymatic peroxidizing lipid-protein reaction exists in the serum and aorta.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.32.2.281
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/322/322.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 32, 号 2, p. 281-302, 発行日 1970-01
著者版フラグ
値 publisher
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