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SH Compounds and Atherosclerosis
https://doi.org/10.18999/nagjms.32.2.281
https://doi.org/10.18999/nagjms.32.2.281a368f709-f767-4737-8cdf-c2f03dfef52a
名前 / ファイル | ライセンス | アクション |
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v32n2p281_302.pdf (3.0 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2013-10-04 | |||||
タイトル | ||||||
タイトル | SH Compounds and Atherosclerosis | |||||
言語 | en | |||||
著者 |
TAKAGI, YUKIO
× TAKAGI, YUKIO |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述 | Fatty acid peroxides have been found in the atherosclerotic human aorta. Glavind found a correlation between the extent of the atherosclerotic changes and the content of lipid peroxides. These lipid peroxides are very toxic to the tissues. There are several compounds in the tissues to counteract the toxicity of peroxides in vivo, i.e. SH compounds, ascorbic acid, or tocopherol. · It may be inferred that an increase of peroxides and a decrease of SH compounds occur in the experimental atherosclerotic aorta and that the administration of such reducing substances as ascorbic acid or SH compounds reactivates the respiration of the aorta inhibited by peroxides and retards the atherogenesis. It may be also supposed that a decrease of SH compounds occurs in the human atherosclerotic aorta. From these considerations the present investigations were performed. In the rabbits fed cholesterol, a decrease of nonprotein SH content and an increase of TEA reactive substances were observed in the aorta at the stage when the reduction of respiratory activity was not revealed. Furthermore, a decrease of total SH content was observed· in the serum, while total SH, nonprotein SH contents and SDH activity were normal in the liver. In the rabbits fed cholesterol with concomitant administration of ascorbic acid or SH compounds, the grade of atherosclerosis and the abnormality of total cholesterol and total SH contents were improved. The development of atherosclerosis was retarded as compared with the control, while the abnormality of lipids in quantity and of fatty acid composition was not improved. Nonprotein SH content in the human atherosclerotic abdominal aorta decreased as compared with the normal aorta. From these results, it may be concluded on atherogenesis that a damage of protein induced by nonenzymatic peroxidizing lipid-protein reaction exists in the serum and aorta. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.32.2.281 | |||||
ID登録タイプ | JaLC | |||||
関連情報 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/322/322.html | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 32, 号 2, p. 281-302, 発行日 1970-01 |
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著者版フラグ | ||||||
値 | publisher |