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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 32(2)

The Possible Role of Lipoperoxide in Aging

https://doi.org/10.18999/nagjms.32.2.303
https://doi.org/10.18999/nagjms.32.2.303
cb79626e-03fa-49aa-a45a-4d4bc880d422
名前 / ファイル ライセンス アクション
v32n2p303_326.pdf v32n2p303_326.pdf (2.9 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-10-04
タイトル
タイトル The Possible Role of Lipoperoxide in Aging
著者 KAWASHIMA, SHIRO

× KAWASHIMA, SHIRO

WEKO 98570

KAWASHIMA, SHIRO

Search repository
抄録
内容記述 According to the free radical theory by Harman, free radicals formed under various conditiors can cause the changes in DNA, which may result in chromosomal aberrations, and can initiate lipid peroxidation in subcellular and cellular membrane systems. The accumulation cf lipofuscin with age also supports the significance of lipid peroxidation on aging. In this paper·;two lines of research were carried out. In experiment 1, peroxidized methyl linoleate was administered to the rats with or without supplementation of antioxidant (α-tocopherol felurate) in order to observe the toxic effects and the possibility of absorption from gastrointestinal tract. The changes of total nitrogen, total lipid, phospholipid, and total tocopherol and TBA reactive substances, which were estimated by two different ways, were observed in the livers of rats. The changes in appearance and the decrease of body weight were recognized in peroxidized oil administered groups. Total lipid and total tocopherol decreased in the liver of peroxidized oil administered groups, whereas there was no significant difference in the ratio of total tocopherol per total lipid. TBA reactive substances by non-shaking method increased in per- oxidized oil administered groups. Considering the above findings, serious toxic effects due to the oral administration of peroxidized methyl linoleate could not be protected by supplementation of antioxidant, and the peroxidized methyl linoleate or the destroyed products of it might be absorbed directly from the gastrointestinal tract. In experiment II, age trends of the same substances as estimated in experiment I and of water soluble antioxidants by DPPH method were investigated in the liver of rats and human subjects. In both, content of water-soluble antioxidants decreased significantly with age and in contrast, total tocopherol increased in mature adult and mature old. In the rat liver the increase of TBA reactive substances was associated with age. In the human liver TBA reactive substances by shaking method increased from the young to the mature adult and decreased again in the old senescense. Assuming from the results of TBA reactive substances, the capacity of lipoperoxide formation reaches to maximum in mature adult and the amount of lipoperoxide formation may increase with age.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.32.2.303
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/322/322.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 32, 号 2, p. 303-326, 発行日 1970-01
著者版フラグ
値 publisher
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