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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 34(1)

A Study on the Clinical Significance of Serum and Urinary Muramidase Activity in Leukemics

https://doi.org/10.18999/nagjms.34.1.13
https://doi.org/10.18999/nagjms.34.1.13
ac7d2454-3042-475f-bc24-d7ec143d767a
名前 / ファイル ライセンス アクション
v34n1p13_26.pdf v34n1p13_26.pdf (2.0 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-10-09
タイトル
タイトル A Study on the Clinical Significance of Serum and Urinary Muramidase Activity in Leukemics
著者 NAGASE, HIROAKI

× NAGASE, HIROAKI

WEKO 49558

NAGASE, HIROAKI

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抄録
内容記述 A study was made on serum and urinary muramidase in 56 patients with leukemia and other hematologic disorders. Serum and urinary muramidase levels prior to antileukemic therapy were elevated in monocytic leukemia, while not so increased in paramyeloblastic leukemia. In all patients with acute lymphocytic leukemia pretreatment serum enzyme activities were decreased below normal, whereas those in patients with acute myelocytic leukemia were normal or slightly increased. In other hematologic diseases the mean values of serum muramidase levels before treatment were elevated slightly or moderately. Extreme urinary muramidase excretion was found in untreated patients with monocytic leukemia in contrast to none or little amount in the other groups. The serum and urinary muramidase levels changed in close correlation with peripheral leukocyte counts, bone marrow contents and clinical status in patients with monocytic leukemia. When antileukemic therapy was effective, serum and urinary muramidase levels fell toward the normal as leukemic cell counts decreased. During complete remission serum enzyme levels remained within normal range and muramidasuria was never found. Following relapse muramidase levels began to rise. Serum and urinary enzyme activities increased in a patient with monocytic leukemia in whom only a few blastic cells were found in peripheral blood and bone marrow. On the basis of the present results, diagnostic value of serum and urinary muramidase activity and the relationship between the clinical status and the enzyme activity in leukemia, especially in monocytic leukemia, were discussed.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.34.1.13
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 34, 号 1, p. 13-26, 発行日 1971-06
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/341/341.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/18681
識別子タイプ HDL
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