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A Study on the Clinical Significance of Serum and Urinary Muramidase Activity in Leukemics
https://doi.org/10.18999/nagjms.34.1.13
https://doi.org/10.18999/nagjms.34.1.13ac7d2454-3042-475f-bc24-d7ec143d767a
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2013-10-09 | |||||
タイトル | ||||||
タイトル | A Study on the Clinical Significance of Serum and Urinary Muramidase Activity in Leukemics | |||||
言語 | en | |||||
著者 |
NAGASE, HIROAKI
× NAGASE, HIROAKI |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A study was made on serum and urinary muramidase in 56 patients with leukemia and other hematologic disorders. Serum and urinary muramidase levels prior to antileukemic therapy were elevated in monocytic leukemia, while not so increased in paramyeloblastic leukemia. In all patients with acute lymphocytic leukemia pretreatment serum enzyme activities were decreased below normal, whereas those in patients with acute myelocytic leukemia were normal or slightly increased. In other hematologic diseases the mean values of serum muramidase levels before treatment were elevated slightly or moderately. Extreme urinary muramidase excretion was found in untreated patients with monocytic leukemia in contrast to none or little amount in the other groups. The serum and urinary muramidase levels changed in close correlation with peripheral leukocyte counts, bone marrow contents and clinical status in patients with monocytic leukemia. When antileukemic therapy was effective, serum and urinary muramidase levels fell toward the normal as leukemic cell counts decreased. During complete remission serum enzyme levels remained within normal range and muramidasuria was never found. Following relapse muramidase levels began to rise. Serum and urinary enzyme activities increased in a patient with monocytic leukemia in whom only a few blastic cells were found in peripheral blood and bone marrow. On the basis of the present results, diagnostic value of serum and urinary muramidase activity and the relationship between the clinical status and the enzyme activity in leukemia, especially in monocytic leukemia, were discussed. | |||||
言語 | en | |||||
出版者 | ||||||
出版者 | Nagoya University School of Medicine | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.34.1.13 | |||||
ID登録タイプ | JaLC | |||||
関連情報 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/341/341.html | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 34, 号 1, p. 13-26, 発行日 1971-06 |
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著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/18681 | |||||
識別子タイプ | HDL |