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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 34(2)

Electron Microscopic Studies on the Adrenal of Rat Treated with Aminoglutethimide : With Special Reference to Accumulation of Cholesterol in Intramitochondrial Vacuoles

https://doi.org/10.18999/nagjms.34.2.183
https://doi.org/10.18999/nagjms.34.2.183
7ee4ff9b-2a9c-4e82-91ab-481cd76761a9
名前 / ファイル ライセンス アクション
v34n2p183_190.pdf v34n2p183_190.pdf (3.7 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-10-10
タイトル
タイトル Electron Microscopic Studies on the Adrenal of Rat Treated with Aminoglutethimide : With Special Reference to Accumulation of Cholesterol in Intramitochondrial Vacuoles
著者 ITOH, GEN

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WEKO 98603

ITOH, GEN

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抄録
内容記述 Aminoglutethimide (Elipten, Ciba,) interferes with the biosynthesis of adrenocortical hormones by blocking the conversion of cholesterol to pregnenolone. Male albino rats were fed with the diet containing aminoglutethimide and were killed after various time intervals ranging from 24 hours to 7 days. The adrenal cortices of these animals were studied both by light and electron microscopy. Special effort was made to determine the intracellular localization of free cholesterol by an electron microscopic histochemical method using the digitonin reaction. The animals killed 24 hours after the initiation of the feeding were found to have small myelin figures in contact with the mitochondrial membrane in fasciculata cells which might reflect compensatory rise of ACTH. The animals fed with the diet for 4 to 7 days were shown to have enlarged adrenal cortex. Light microscopic examination revealed an increase of the lipid globules both in size and number in the zona fasciculata. Ultrastructural studies showed swollen, hypertrophied, bizarre prophiles of the mitochondria with the formation of the vacuoles. The electron microscopic histochemical method demonstrated digitonincholesterol crystals localized in the vacuoles of the mitochondria, in the perimitochondrial areas and in the lipid globules. These findings correlate well with the biochemical data which indicate the intracellular site of steroid bicsynthesis and lend morphological support to the view that the biosynthesis of pregnenolone from cholesterol takes place within the mitochondria. These results indicate that aminoglutethimide causes accumulation of cholesterol in the vacuoles of the mitochondria.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.34.2.183
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/342/342.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 34, 号 2, p. 183-190, 発行日 1971-09
著者版フラグ
値 publisher
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