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Hemodynamic Effects of Beta Adrenergic Receptor Stimulant and Blockade Hemodynamic Effects of Isoproterenol after Propranolol
https://doi.org/10.18999/nagjms.34.3.199
https://doi.org/10.18999/nagjms.34.3.1995d1d9409-9dd9-4055-80d4-778004a8a66f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
v34n3p199_212.pdf (2.8 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-10-10 | |||||
| タイトル | ||||||
| タイトル | Hemodynamic Effects of Beta Adrenergic Receptor Stimulant and Blockade Hemodynamic Effects of Isoproterenol after Propranolol | |||||
| 言語 | en | |||||
| 著者 |
FUKUTA, IWAO
× FUKUTA, IWAO |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The effects of isoproterenol and propranolol on the hemodynamics were evaluated in dogs for the purpose of their clinical application in the management of cardiovascular surgical patients. In dogs receiving 0.002 mg/kg of isoproterenol intravenously with one shot, marked positive inotropic and chronotropic responses were achieved in 5 seconds and returned to the control values in 5 minutes. Heart rate, myocardial contractility, coronary blood flow and cardiac output increased markedly, but blood pressure decreased by about 50%. In dogs receiving the same dose of isoproterenol infusion over 15 minutes, similar changes were achieved, though milder. The effect remained stable during infusion. Isoproterenol iufusion was thought to be superior to injection as one shot in clinical application. In dogs receiving 0.2 m/kg of propranolol intravenously, depressing inotropic and chronotropic effects appeared in a few minutes. Myocardial contractility, cardiac output and heart rate decreased, but stroke volume increased. When 0.002 mg/kg of isoproterenol was injected after propranolol, the effects of isoproterenol were milder. The effect of isoproterenol to decrease blood pressure was prevented by propranolol. Isoproterenol infusion after propranolol injection resulted in a significant increase in myocardial contractility and a less in heart rate by overcoming the effects of propranolol with a far less increase in myocardial oxygen consumption. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.34.3.199 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/343/343.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 34, 号 3, p. 199-212, 発行日 1972-02 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/18694 | |||||
| 識別子タイプ | HDL | |||||
