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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 34(3)

Hemodynamic Effects of Beta Adrenergic Receptor Stimulant and Blockade Hemodynamic Effects of Isoproterenol after Propranolol

https://doi.org/10.18999/nagjms.34.3.199
https://doi.org/10.18999/nagjms.34.3.199
5d1d9409-9dd9-4055-80d4-778004a8a66f
名前 / ファイル ライセンス アクション
v34n3p199_212.pdf v34n3p199_212.pdf (2.8 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-10-10
タイトル
タイトル Hemodynamic Effects of Beta Adrenergic Receptor Stimulant and Blockade Hemodynamic Effects of Isoproterenol after Propranolol
著者 FUKUTA, IWAO

× FUKUTA, IWAO

WEKO 49577

FUKUTA, IWAO

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抄録
内容記述 The effects of isoproterenol and propranolol on the hemodynamics were evaluated in dogs for the purpose of their clinical application in the management of cardiovascular surgical patients. In dogs receiving 0.002 mg/kg of isoproterenol intravenously with one shot, marked positive inotropic and chronotropic responses were achieved in 5 seconds and returned to the control values in 5 minutes. Heart rate, myocardial contractility, coronary blood flow and cardiac output increased markedly, but blood pressure decreased by about 50%. In dogs receiving the same dose of isoproterenol infusion over 15 minutes, similar changes were achieved, though milder. The effect remained stable during infusion. Isoproterenol iufusion was thought to be superior to injection as one shot in clinical application. In dogs receiving 0.2 m/kg of propranolol intravenously, depressing inotropic and chronotropic effects appeared in a few minutes. Myocardial contractility, cardiac output and heart rate decreased, but stroke volume increased. When 0.002 mg/kg of isoproterenol was injected after propranolol, the effects of isoproterenol were milder. The effect of isoproterenol to decrease blood pressure was prevented by propranolol. Isoproterenol infusion after propranolol injection resulted in a significant increase in myocardial contractility and a less in heart rate by overcoming the effects of propranolol with a far less increase in myocardial oxygen consumption.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.34.3.199
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 34, 号 3, p. 199-212, 発行日 1972-02
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/343/343.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/18694
識別子タイプ HDL
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