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Uncoupling Effect of Hypoglycemic Sulphonylureas on the Isolated Rat Liver Mitochondria
https://doi.org/10.18999/nagjms.35.2-4.141
https://doi.org/10.18999/nagjms.35.2-4.141ae8c339b-267b-41f5-b7ed-5b1344ee924d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
v35n24p141_150.pdf (1.2 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2013-10-17 | |||||
| タイトル | ||||||
| タイトル | Uncoupling Effect of Hypoglycemic Sulphonylureas on the Isolated Rat Liver Mitochondria | |||||
| 言語 | en | |||||
| 著者 |
KATSUMATA, KAZUO
× KATSUMATA, KAZUO× HAGIHARA, MASAKO |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The effect of several hypoglycemic sulphonylureas upon the oxidative phos- phorylation of intact rat liver mitochondria was examined. Following results were obtained and discussed in relation to hypoglycemic action and uncoupling site of these drugs. 1. All hypoglycemic sulphonylurea drugs tested, i.e., tolbutamide, carbutamide, chlorpropamide, acetohexamide, glybenclamide, and glyclopyramide were found to be uncouplers to the intact rat liver mitochonbria. 2. They were also found to decrease respiratory release of 20 ,µM DNP. 3. Sulphonylureas could induce latent ATPase activity of intact rat liver mitochondria. ATPase activity induced by glybenclamide was reduced to zero by the addition of rutamycin just like DNP. 4, Judging from the above data, uncoupling site of sulphonylureas may be near DNP site. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.35.2-4.141 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/3524/3524.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 35, 号 2-4, p. 141-150, 発行日 1973-03 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
