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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 35(2-4)

Uncoupling Effect of Hypoglycemic Sulphonylureas on the Isolated Rat Liver Mitochondria

https://doi.org/10.18999/nagjms.35.2-4.141
https://doi.org/10.18999/nagjms.35.2-4.141
ae8c339b-267b-41f5-b7ed-5b1344ee924d
名前 / ファイル ライセンス アクション
v35n24p141_150.pdf v35n24p141_150.pdf (1.2 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-10-17
タイトル
タイトル Uncoupling Effect of Hypoglycemic Sulphonylureas on the Isolated Rat Liver Mitochondria
著者 KATSUMATA, KAZUO

× KATSUMATA, KAZUO

WEKO 98616

KATSUMATA, KAZUO

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HAGIHARA, MASAKO

× HAGIHARA, MASAKO

WEKO 98617

HAGIHARA, MASAKO

Search repository
抄録
内容記述 The effect of several hypoglycemic sulphonylureas upon the oxidative phos- phorylation of intact rat liver mitochondria was examined. Following results were obtained and discussed in relation to hypoglycemic action and uncoupling site of these drugs. 1. All hypoglycemic sulphonylurea drugs tested, i.e., tolbutamide, carbutamide, chlorpropamide, acetohexamide, glybenclamide, and glyclopyramide were found to be uncouplers to the intact rat liver mitochonbria. 2. They were also found to decrease respiratory release of 20 ,µM DNP. 3. Sulphonylureas could induce latent ATPase activity of intact rat liver mitochondria. ATPase activity induced by glybenclamide was reduced to zero by the addition of rutamycin just like DNP. 4, Judging from the above data, uncoupling site of sulphonylureas may be near DNP site.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.35.2-4.141
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/3524/3524.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 35, 号 2-4, p. 141-150, 発行日 1973-03
著者版フラグ
値 publisher
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