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Malignant Lymphoma and Amyloidosis Following Graft-Versus-Host Reaction
https://doi.org/10.18999/nagjms.35.2-4.151
https://doi.org/10.18999/nagjms.35.2-4.151665ce3f1-da4d-497c-a038-52202467f384
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
v35n24p151_155.pdf (680.7 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2013-10-17 | |||||
| タイトル | ||||||
| タイトル | Malignant Lymphoma and Amyloidosis Following Graft-Versus-Host Reaction | |||||
| 言語 | en | |||||
| 著者 |
TANAKA, MINEYA
× TANAKA, MINEYA× SHIBATA, TOSHIHIKO× ITO, YASUHIKO× KUNII, AKIRA |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Persistent stimulation of immunocompetent cells, such as histocompatibility reactions, may be one of the causes of neoplastic proliferation of lymphoreticular tissues. In the present studies, the graft-versus-host reaction was induced in 18-week-old male (C 57 Bl/6Jx DBA/2J)F1 mice by two or four weekly intraperitoneal injections of approximately 80 x 10^6 male C 57 Bl/6 J or C 57 Bl/Na mouse lymphoid cells. Some of the recipient mice were treated with amethopterin. The majority of mice dying soon after injection of parental lymphoid cells showed signs of runt diesase and most animals recovering from the disease survived and were alive at the age of 24 months, at the termination of the experiments. Histological studies of 94 mice of experimental groups revealed lymphomatous changes in 10 mice and a moderate to extensive amyloidosis in 22 mice, with no abnormal changes in 15 untreated control mice. Nine out of 10 lymphomas were Type B, only one being reticulum cell sarcoma, Type A. Five out of 9 Type B lymphomas were associated with amyloidosis. Comparative analysis of mortality rates due to runt disease, and incidences of lymphoma and amyloidosis in each experimental group showed that the resulting lymphoma incidences were apparently indifferent to the severity of runt disease. The results obtained in the present studies, together with those in others, suggest that the overt graft-versus-host reaction may not be a necessary precondition for increased lymphomagenesis in parental-F1 hybrid chimeras and that factors other than the graft-versus-host reaction itself may also be involved. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.35.2-4.151 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/3524/3524.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 35, 号 2-4, p. 151-155, 発行日 1973-03 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
