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Up-regulation of Gr1^+CD11b^+ cell population in the spleen of NaClO-administered mice works to repair skin wounds
http://hdl.handle.net/2237/18821
http://hdl.handle.net/2237/1882181cb5bd9-7401-4517-beeb-db495a61f5d7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
k9991.pdf (446.2 kB)
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| アイテムタイプ | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-11-06 | |||||
| タイトル | ||||||
| タイトル | Up-regulation of Gr1^+CD11b^+ cell population in the spleen of NaClO-administered mice works to repair skin wounds | |||||
| 言語 | en | |||||
| 著者 |
Hara, Mayu
× Hara, Mayu× Nishio, Naomi× Ito, Sachiko× Akiyama, Masashi× Isobe, Ken-ichi |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 権利情報 | © 2012 Hara et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, provided the original authors and source are credited. | |||||
| 言語 | en | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | neutrophils | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | wound healing | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | GR-1^+CD11b^+ cells | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In wound healing, early infiltration of neutrophils followed by macrophage infiltration are important defense mechanisms for repair of tissue damage. Here we examined the effects of neutrophils on wound healing. Administration of sodium hypochlorite (NaClO) to mouse skin induces neutrophil recruitment to the wound site and repeated administration of NaClO was shown to prolong wound healing. Examination of the spleens of mice whose wounds were repeatedly treated with NaClO, showed that GR-1^+CD11b^+ cells were up regulated in the recovery phase of wounding. Many of the GR-1^+CD11b^+ cells in the mouse bone marrow were neutrophils, as indicated by a ring-shaped nucleus, and some of the cells were immature myeloid-lineage cells. GR-1^+CD11b^+ cells from bone marrow were sorted and injected intravenously to syngeneic Imprinting Control Region (ICR) mice. The mice that received GR-1^+CD11b^+ cells recovered faster than the mice injected with the control, phosphate buffer saline (PBS). | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成25年3月25日 原真由氏の博士論文として提出された | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Biodiscovery | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_db06 | |||||
| タイプ | doctoral thesis | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.7750/BioDiscovery.2012.2.1 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2050-2966 | |||||
| 書誌情報 |
en : Biodiscovery 巻 2, p. 1-1, 発行日 2012-08-06 |
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| 学位名 | ||||||
| 学位名 | 博士(医学) | |||||
| 言語 | ja | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 13901 | |||||
| 学位授与機関名 | 名古屋大学 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | Nagoya University | |||||
| 言語 | en | |||||
| 学位授与年度 | ||||||
| 学位授与年度 | 2012 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2012-08-06 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第9991号 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://dx.doi.org/10.7750/BioDiscovery.2012.2.1 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/18821 | |||||
| 識別子タイプ | HDL | |||||
