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Mast cells promote the growth of Hodgkin's lymphoma cell tumor by modifying the tumor microenvironment that can be perturbed by bortezomib
http://hdl.handle.net/2237/18834
http://hdl.handle.net/2237/18834b0d17caf-1e90-4e15-b77b-8d737be14905
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
18314_1_merged.pdf (688.4 kB)
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| アイテムタイプ | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-11-08 | |||||
| タイトル | ||||||
| タイトル | Mast cells promote the growth of Hodgkin's lymphoma cell tumor by modifying the tumor microenvironment that can be perturbed by bortezomib | |||||
| 言語 | en | |||||
| 著者 |
Mizuno, Hiroki
× Mizuno, Hiroki× Nakayama, Takayuki× Miyata, Yasuhiko× Saito, Shigeki× Nishiwaki, Satoshi× Nakao, Norihiko× Takeshita, Kyosuke× Naoe, Tomoki |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Hodgkin's lymphoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mast cells | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | angiogenesis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | fibrosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | bortezomib | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Hodgkin's lymphoma is frequently associated with mast cell infiltration that correlates directly with disease severity, but the mechanisms underlying this relationship remain unclear. Here, we report that mast cells promote the growth of Hodgkin's tumor by modifying the tumor microenvironment. A transplantation assay shows that primary murine mast cells accelerate tumor growth by established Hodgkin's cell lines, and promote marked neovascularization and fibrosis. Both mast cells and Hodgkin's cells were sensitive to bortezomib, but mast cells were more resistant to bortezomib. However, bortezomib inhibited degranulation, PGE2-induced rapid release of CCL2, and continuous release of vascular endothelial growth factor-A from mast cells even at the concentration that did not induce cell death. Bortezomib-treated mast cells lost the ability to induce neovasculization and fibrosis, and did not promote the growth of Hodgkin tumor in vivo. These results provide further evidence supporting causal relationships between inflammation and tumor growth, and demonstrate that bortezomib can target the tumor microenvironment. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成25年3月25日 水野紘樹氏の博士論文として提出された | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | nature | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_db06 | |||||
| タイプ | doctoral thesis | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1038/leu.2012.81 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0887-6924 | |||||
| 書誌情報 |
en : Leukemia 巻 26, p. 2269-2276, 発行日 2012-04-20 |
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| 学位名 | ||||||
| 学位名 | 博士(医学) | |||||
| 言語 | ja | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 13901 | |||||
| 学位授与機関名 | 名古屋大学 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | Nagoya University | |||||
| 言語 | en | |||||
| 学位授与年度 | ||||||
| 学位授与年度 | 2012 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2012-04-20 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第9995号 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://dx.doi.org/10.1038/leu.2012.81 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/18834 | |||||
| 識別子タイプ | HDL | |||||
