{"_buckets": {"deposit": "fe0d8a44-fd0d-43bc-a621-e498399e45fb"}, "_deposit": {"id": "16805", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "16805"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00016805", "sets": ["1165"]}, "author_link": ["49930", "49931", "49932", "49933", "49934", "49935", "49936", "49937"], "item_12_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2012-04-20", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "2276", "bibliographicPageStart": "2269", "bibliographicVolumeNumber": "26", "bibliographic_titles": [{"bibliographic_title": "Leukemia", "bibliographic_titleLang": "en"}]}]}, "item_12_date_granted_64": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2012-04-20"}]}, "item_12_degree_grantor_62": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_language": "ja", "subitem_degreegrantor_name": "名古屋大学"}, {"subitem_degreegrantor_language": "en", "subitem_degreegrantor_name": "Nagoya University"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "13901", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_12_degree_name_61": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)", "subitem_degreename_language": "ja"}]}, "item_12_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Hodgkin\u0027s lymphoma is frequently associated with mast cell infiltration that correlates directly with disease severity, but the mechanisms underlying this relationship remain unclear. Here, we report that mast cells promote the growth of Hodgkin\u0027s tumor by modifying the tumor microenvironment. A transplantation assay shows that primary murine mast cells accelerate tumor growth by established Hodgkin\u0027s cell lines, and promote marked neovascularization and fibrosis. Both mast cells and Hodgkin\u0027s cells were sensitive to bortezomib, but mast cells were more resistant to bortezomib. However, bortezomib inhibited degranulation, PGE2-induced rapid release of CCL2, and continuous release of vascular endothelial growth factor-A from mast cells even at the concentration that did not induce cell death. Bortezomib-treated mast cells lost the ability to induce neovasculization and fibrosis, and did not promote the growth of Hodgkin tumor in vivo. These results provide further evidence supporting causal relationships between inflammation and tumor growth, and demonstrate that bortezomib can target the tumor microenvironment.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_12_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成25年3月25日 水野紘樹氏の博士論文として提出された", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_12_dissertation_number_65": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第9995号"}]}, "item_12_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "DOI", "subitem_identifier_uri": "http://dx.doi.org/10.1038/leu.2012.81"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/18834"}]}, "item_12_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "nature", "subitem_publisher_language": "en"}]}, "item_12_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1038/leu.2012.81", "subitem_relation_type_select": "DOI"}}]}, "item_12_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_12_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0887-6924", "subitem_source_identifier_type": "PISSN"}]}, "item_12_text_63": {"attribute_name": "学位授与年度", "attribute_value_mlt": [{"subitem_text_value": "2012"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Mizuno, Hiroki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "49930", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakayama, Takayuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "49931", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyata, Yasuhiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "49932", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saito, Shigeki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "49933", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishiwaki, Satoshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "49934", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakao, Norihiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "49935", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takeshita, Kyosuke", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "49936", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Naoe, Tomoki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "49937", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "18314_1_merged.pdf", "filesize": [{"value": "688.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 688400.0, "url": {"label": "18314_1_merged.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/16805/files/18314_1_merged.pdf"}, "version_id": "d305cf2e-5c10-455d-8e74-c6a039d6359a"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Hodgkin\u0027s lymphoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mast cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "angiogenesis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "fibrosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "bortezomib", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Mast cells promote the growth of Hodgkin\u0027s lymphoma cell tumor by modifying the tumor microenvironment that can be perturbed by bortezomib", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Mast cells promote the growth of Hodgkin\u0027s lymphoma cell tumor by modifying the tumor microenvironment that can be perturbed by bortezomib", "subitem_title_language": "en"}]}, "item_type_id": "12", "owner": "1", "path": ["1165"], "permalink_uri": "http://hdl.handle.net/2237/18834", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2013-11-08"}, "publish_date": "2013-11-08", "publish_status": "0", "recid": "16805", "relation": {}, "relation_version_is_last": true, "title": ["Mast cells promote the growth of Hodgkin\u0027s lymphoma cell tumor by modifying the tumor microenvironment that can be perturbed by bortezomib"], "weko_shared_id": -1}