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  1. C100 医学部/医学系研究科
  2. C100d 学位論文
  3. 博士論文(医博・論医博)

Impact of novel oncolytic virus HF10 on cellular components of the tumor microenviroment in patients with recurrent breast cancer

http://hdl.handle.net/2237/18933
e77383e7-57eb-451c-b3fe-b8028c09e78a
名前 / ファイル ライセンス アクション
k9929_thesis.pdf k9929_thesis.pdf (214.7 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2013-11-20
タイトル
タイトル Impact of novel oncolytic virus HF10 on cellular components of the tumor microenviroment in patients with recurrent breast cancer
著者 Sahin, TT

× Sahin, TT

WEKO 50244

Sahin, TT

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Kasuya, H

× Kasuya, H

WEKO 50245

Kasuya, H

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Nomura, N

× Nomura, N

WEKO 50246

Nomura, N

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Shikano, T

× Shikano, T

WEKO 50247

Shikano, T

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Yamamura, K

× Yamamura, K

WEKO 50248

Yamamura, K

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Gewen, T

× Gewen, T

WEKO 50249

Gewen, T

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Kanzaki, A

× Kanzaki, A

WEKO 50250

Kanzaki, A

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Fujii, T

× Fujii, T

WEKO 50251

Fujii, T

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Sugae, T

× Sugae, T

WEKO 50252

Sugae, T

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Imai, T

× Imai, T

WEKO 50253

Imai, T

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Nomoto, S

× Nomoto, S

WEKO 50254

Nomoto, S

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Takeda, S

× Takeda, S

WEKO 50255

Takeda, S

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Sugimoto, H

× Sugimoto, H

WEKO 50256

Sugimoto, H

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Kikumori, T

× Kikumori, T

WEKO 50257

Kikumori, T

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Kodera, Y

× Kodera, Y

WEKO 50258

Kodera, Y

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Nishiyama, Y

× Nishiyama, Y

WEKO 50259

Nishiyama, Y

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Nakao, A

× Nakao, A

WEKO 50260

Nakao, A

Search repository
キーワード
主題Scheme Other
主題 angiogenesis
キーワード
主題Scheme Other
主題 apoptosis
キーワード
主題Scheme Other
主題 breast cancer
キーワード
主題Scheme Other
主題 herpes virus
キーワード
主題Scheme Other
主題 HF10
キーワード
主題Scheme Other
主題 oncolytic virus
キーワード
主題Scheme Other
主題 microenvironment
抄録
内容記述 Oncolytic viruses are a promising method of cancer therapy, even for advanced malignancies. HF10, a spontaneously mutated herpes simplex type 1, is a potent oncolytic agent. The interaction of oncolytic herpes viruses with the tumor microenvironment has not been well characterized. We injected HF10 into tumors of patients with recurrent breast carcinoma, and sought to determine its effects on the tumor microenvironment. Six patients with recurrent breast cancer were recruited to the study. Tumors were divided into two groups: saline-injected (control) and HF10-injected (treatment). We investigated several parameters including neovascularization (CD31) and tumor lymphocyte infiltration (CD8, CD4), determined by immunohistochemistry, and apoptosis, determined by terminal deoxynucleotidyl transferase dUTP nick end labeling assay. Median apoptotic cell count was lower in the treatment group (P=0.016). Angiogenesis was significantly higher in treatment group (P=0.032). Count of CD8-positive lymphocytes infiltrating the tumors was higher in the treatment group (P=0.008). We were unable to determine CD4-positive lymphocyte infiltration. An effective oncolytic viral agent must replicate efficiently in tumor cells, leading to higher viral counts, in order to aid viral penetration. HF10 seems to meet this criterion; furthermore, it induces potent antitumor immunity. The increase in angiogenesis may be due to either viral replication or the inflammatory response.
内容記述タイプ Abstract
内容記述
内容記述 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成25年1月31日 Tevfik Tolga SAHIN氏の博士論文として提出された
内容記述タイプ Other
出版者
出版者 nature
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
ISSN
収録物識別子タイプ ISSN
収録物識別子 0929-1903
書誌情報 Cancer Gene Therapy

巻 19, 号 4, p. 229-237, 発行日 2012-04
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 名古屋大学
学位授与年度
学位授与年度 2012
学位授与年月日
学位授与年月日 2012-04-01
学位授与番号
学位授与番号 13901甲第9929号
著者版フラグ
値 publisher
URI
識別子 http://dx.doi.org/10.1038/cgt.2011.80
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/18933
識別子タイプ HDL
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