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Impact of novel oncolytic virus HF10 on cellular components of the tumor microenviroment in patients with recurrent breast cancer
http://hdl.handle.net/2237/18933
http://hdl.handle.net/2237/18933e77383e7-57eb-451c-b3fe-b8028c09e78a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
k9929_thesis.pdf (214.7 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-11-20 | |||||
| タイトル | ||||||
| タイトル | Impact of novel oncolytic virus HF10 on cellular components of the tumor microenviroment in patients with recurrent breast cancer | |||||
| 言語 | en | |||||
| 著者 |
Sahin, TT
× Sahin, TT× Kasuya, H× Nomura, N× Shikano, T× Yamamura, K× Gewen, T× Kanzaki, A× Fujii, T× Sugae, T× Imai, T× Nomoto, S× Takeda, S× Sugimoto, H× Kikumori, T× Kodera, Y× Nishiyama, Y× Nakao, A |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | angiogenesis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | apoptosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | breast cancer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | herpes virus | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | HF10 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | oncolytic virus | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | microenvironment | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Oncolytic viruses are a promising method of cancer therapy, even for advanced malignancies. HF10, a spontaneously mutated herpes simplex type 1, is a potent oncolytic agent. The interaction of oncolytic herpes viruses with the tumor microenvironment has not been well characterized. We injected HF10 into tumors of patients with recurrent breast carcinoma, and sought to determine its effects on the tumor microenvironment. Six patients with recurrent breast cancer were recruited to the study. Tumors were divided into two groups: saline-injected (control) and HF10-injected (treatment). We investigated several parameters including neovascularization (CD31) and tumor lymphocyte infiltration (CD8, CD4), determined by immunohistochemistry, and apoptosis, determined by terminal deoxynucleotidyl transferase dUTP nick end labeling assay. Median apoptotic cell count was lower in the treatment group (P=0.016). Angiogenesis was significantly higher in treatment group (P=0.032). Count of CD8-positive lymphocytes infiltrating the tumors was higher in the treatment group (P=0.008). We were unable to determine CD4-positive lymphocyte infiltration. An effective oncolytic viral agent must replicate efficiently in tumor cells, leading to higher viral counts, in order to aid viral penetration. HF10 seems to meet this criterion; furthermore, it induces potent antitumor immunity. The increase in angiogenesis may be due to either viral replication or the inflammatory response. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成25年1月31日 Tevfik Tolga SAHIN氏の博士論文として提出された | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | nature | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1038/cgt.2011.80 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0929-1903 | |||||
| 書誌情報 |
en : Cancer Gene Therapy 巻 19, 号 4, p. 229-237, 発行日 2012-04 |
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| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 13901 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 名古屋大学 | |||||
| 言語 | en | |||||
| 学位授与機関名 | Nagoya University | |||||
| 学位授与年度 | ||||||
| 値 | 2012 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2012-04-01 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第9929号 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://dx.doi.org/10.1038/cgt.2011.80 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/18933 | |||||
| 識別子タイプ | HDL | |||||
