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  1. C100 医学部/医学系研究科
  2. C100d 学位論文
  3. 博士論文(医博・論医博)

Impact of novel oncolytic virus HF10 on cellular components of the tumor microenviroment in patients with recurrent breast cancer

http://hdl.handle.net/2237/18933
http://hdl.handle.net/2237/18933
e77383e7-57eb-451c-b3fe-b8028c09e78a
名前 / ファイル ライセンス アクション
k9929_thesis.pdf k9929_thesis.pdf (214.7 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2013-11-20
タイトル
タイトル Impact of novel oncolytic virus HF10 on cellular components of the tumor microenviroment in patients with recurrent breast cancer
言語 en
著者 Sahin, TT

× Sahin, TT

WEKO 50244

en Sahin, TT

Search repository
Kasuya, H

× Kasuya, H

WEKO 50245

en Kasuya, H

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Nomura, N

× Nomura, N

WEKO 50246

en Nomura, N

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Shikano, T

× Shikano, T

WEKO 50247

en Shikano, T

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Yamamura, K

× Yamamura, K

WEKO 50248

en Yamamura, K

Search repository
Gewen, T

× Gewen, T

WEKO 50249

en Gewen, T

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Kanzaki, A

× Kanzaki, A

WEKO 50250

en Kanzaki, A

Search repository
Fujii, T

× Fujii, T

WEKO 50251

en Fujii, T

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Sugae, T

× Sugae, T

WEKO 50252

en Sugae, T

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Imai, T

× Imai, T

WEKO 50253

en Imai, T

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Nomoto, S

× Nomoto, S

WEKO 50254

en Nomoto, S

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Takeda, S

× Takeda, S

WEKO 50255

en Takeda, S

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Sugimoto, H

× Sugimoto, H

WEKO 50256

en Sugimoto, H

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Kikumori, T

× Kikumori, T

WEKO 50257

en Kikumori, T

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Kodera, Y

× Kodera, Y

WEKO 50258

en Kodera, Y

Search repository
Nishiyama, Y

× Nishiyama, Y

WEKO 50259

en Nishiyama, Y

Search repository
Nakao, A

× Nakao, A

WEKO 50260

en Nakao, A

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 angiogenesis
キーワード
主題Scheme Other
主題 apoptosis
キーワード
主題Scheme Other
主題 breast cancer
キーワード
主題Scheme Other
主題 herpes virus
キーワード
主題Scheme Other
主題 HF10
キーワード
主題Scheme Other
主題 oncolytic virus
キーワード
主題Scheme Other
主題 microenvironment
抄録
内容記述 Oncolytic viruses are a promising method of cancer therapy, even for advanced malignancies. HF10, a spontaneously mutated herpes simplex type 1, is a potent oncolytic agent. The interaction of oncolytic herpes viruses with the tumor microenvironment has not been well characterized. We injected HF10 into tumors of patients with recurrent breast carcinoma, and sought to determine its effects on the tumor microenvironment. Six patients with recurrent breast cancer were recruited to the study. Tumors were divided into two groups: saline-injected (control) and HF10-injected (treatment). We investigated several parameters including neovascularization (CD31) and tumor lymphocyte infiltration (CD8, CD4), determined by immunohistochemistry, and apoptosis, determined by terminal deoxynucleotidyl transferase dUTP nick end labeling assay. Median apoptotic cell count was lower in the treatment group (P=0.016). Angiogenesis was significantly higher in treatment group (P=0.032). Count of CD8-positive lymphocytes infiltrating the tumors was higher in the treatment group (P=0.008). We were unable to determine CD4-positive lymphocyte infiltration. An effective oncolytic viral agent must replicate efficiently in tumor cells, leading to higher viral counts, in order to aid viral penetration. HF10 seems to meet this criterion; furthermore, it induces potent antitumor immunity. The increase in angiogenesis may be due to either viral replication or the inflammatory response.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成25年1月31日 Tevfik Tolga SAHIN氏の博士論文として提出された
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 nature
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/cgt.2011.80
ISSN
収録物識別子タイプ PISSN
収録物識別子 0929-1903
書誌情報 en : Cancer Gene Therapy

巻 19, 号 4, p. 229-237, 発行日 2012-04
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13901
言語 ja
学位授与機関名 名古屋大学
言語 en
学位授与機関名 Nagoya University
学位授与年度
学位授与年度 2012
学位授与年月日
学位授与年月日 2012-04-01
学位授与番号
学位授与番号 甲第9929号
著者版フラグ
値 publisher
URI
識別子 http://dx.doi.org/10.1038/cgt.2011.80
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/18933
識別子タイプ HDL
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