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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 76(1-2)

Rat model demonstrates a high risk of tremolite but a low risk of anthophyllite for mesothelial carcinogenesis

https://doi.org/10.18999/nagjms.76.1-2.149
https://doi.org/10.18999/nagjms.76.1-2.149
2fdf797a-518e-4094-a841-c6f06189ff06
名前 / ファイル ライセンス アクション
16_Aierken.pdf 16_Aierken.pdf (1.7 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2014-03-04
タイトル
タイトル Rat model demonstrates a high risk of tremolite but a low risk of anthophyllite for mesothelial carcinogenesis
著者 AIERKEN, DILINUER

× AIERKEN, DILINUER

WEKO 51176

AIERKEN, DILINUER

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OKAZAKI, YASUMASA

× OKAZAKI, YASUMASA

WEKO 51177

OKAZAKI, YASUMASA

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CHEW, SHAN HWU

× CHEW, SHAN HWU

WEKO 51178

CHEW, SHAN HWU

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SAKAI, AKIHIRO

× SAKAI, AKIHIRO

WEKO 51179

SAKAI, AKIHIRO

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WANG, YUE

× WANG, YUE

WEKO 51180

WANG, YUE

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NAGAI, HIROTAKA

× NAGAI, HIROTAKA

WEKO 51181

NAGAI, HIROTAKA

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MISAWA, NOBUAKI

× MISAWA, NOBUAKI

WEKO 51182

MISAWA, NOBUAKI

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KOHYAMA, NORIHIKO

× KOHYAMA, NORIHIKO

WEKO 51183

KOHYAMA, NORIHIKO

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TOYOKUNI, SHINYA

× TOYOKUNI, SHINYA

WEKO 51184

TOYOKUNI, SHINYA

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キーワード
主題Scheme Other
主題 asbestos
キーワード
主題Scheme Other
主題 mesothelioma
キーワード
主題Scheme Other
主題 tremolite
キーワード
主題Scheme Other
主題 anthophyllite
抄録
内容記述 Asbestos was abundantly used in industry during the last century. Currently, asbestos confers a heavy social burden due to an increasing number of patients with malignant mesothelioma (MM), which develops after a long incubation period. Many studies have been conducted on the effects of the asbestos types that were most commonly used for commercial applications. However, there are few studies describing the effects of the less common types, or minor asbestos. We performed a rat carcinogenesis study using Japanese tremolite and Afghan anthophyllite. Whereas more than 50% of tremolite fibers had a diameter of < 500 nm, only a small fraction of anthophyllite fibers had a diameter of < 500 nm. We intraperitoneally injected 1 or 10 mg of asbestos into F1 Fischer-344/Brown-Norway rats. In half of the animals, repeated intraperitoneal injections of nitrilotriacetate (NTA), an iron chelator to promote Fenton reaction, were performed to evaluate the potential involvement of iron overload. Tremolite induced MM with a high incidence (96% with 10 mg; 52% with 1 mg), and males were more susceptible than females. Histology was confirmed using immunohistochemistry, and most MMs were characterized as the sarcomatoid or biphasic subtype. Unexpectedly NTA showed an inhibitory effect in females. In contrast, anthophyllite induced no MM after an observation period of 550 days. The results suggest that the carcinogenicity of anthophyllite is weaker than formerly reported, whereas that of tremolite is as potent as major asbestos as compared with our previous data.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.76.1-2.149
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 76, 号 1-2, p. 149-160, 発行日 2014-02
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7612/7612.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/19493
識別子タイプ HDL
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