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Rat model demonstrates a high risk of tremolite but a low risk of anthophyllite for mesothelial carcinogenesis
https://doi.org/10.18999/nagjms.76.1-2.149
https://doi.org/10.18999/nagjms.76.1-2.1492fdf797a-518e-4094-a841-c6f06189ff06
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
16_Aierken.pdf (1.7 MB)
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| アイテムタイプ | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-03-04 | |||||
| タイトル | ||||||
| タイトル | Rat model demonstrates a high risk of tremolite but a low risk of anthophyllite for mesothelial carcinogenesis | |||||
| 言語 | en | |||||
| 著者 |
AIERKEN, DILINUER
× AIERKEN, DILINUER× OKAZAKI, YASUMASA× CHEW, SHAN HWU× SAKAI, AKIHIRO× WANG, YUE× NAGAI, HIROTAKA× MISAWA, NOBUAKI× KOHYAMA, NORIHIKO× TOYOKUNI, SHINYA |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | asbestos | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mesothelioma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | tremolite | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | anthophyllite | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Asbestos was abundantly used in industry during the last century. Currently, asbestos confers a heavy social burden due to an increasing number of patients with malignant mesothelioma (MM), which develops after a long incubation period. Many studies have been conducted on the effects of the asbestos types that were most commonly used for commercial applications. However, there are few studies describing the effects of the less common types, or minor asbestos. We performed a rat carcinogenesis study using Japanese tremolite and Afghan anthophyllite. Whereas more than 50% of tremolite fibers had a diameter of < 500 nm, only a small fraction of anthophyllite fibers had a diameter of < 500 nm. We intraperitoneally injected 1 or 10 mg of asbestos into F1 Fischer-344/Brown-Norway rats. In half of the animals, repeated intraperitoneal injections of nitrilotriacetate (NTA), an iron chelator to promote Fenton reaction, were performed to evaluate the potential involvement of iron overload. Tremolite induced MM with a high incidence (96% with 10 mg; 52% with 1 mg), and males were more susceptible than females. Histology was confirmed using immunohistochemistry, and most MMs were characterized as the sarcomatoid or biphasic subtype. Unexpectedly NTA showed an inhibitory effect in females. In contrast, anthophyllite induced no MM after an observation period of 550 days. The results suggest that the carcinogenicity of anthophyllite is weaker than formerly reported, whereas that of tremolite is as potent as major asbestos as compared with our previous data. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.76.1-2.149 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7612/7612.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 76, 号 1-2, p. 149-160, 発行日 2014-02 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/19493 | |||||
| 識別子タイプ | HDL | |||||
