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汗の塩分濃度と膵臓の機能
https://doi.org/10.18999/njhpfs.35.1.9
https://doi.org/10.18999/njhpfs.35.1.998ab89f8-6832-450d-ac97-09c43845b749
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
2_No35-1.pdf (1.2 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-06-11 | |||||
| タイトル | ||||||
| タイトル | 汗の塩分濃度と膵臓の機能 | |||||
| 言語 | ja | |||||
| その他のタイトル | ||||||
| その他のタイトル | Sweat chloride concentration and pancreatic exocrine function | |||||
| 言語 | en | |||||
| 著者 |
石黒, 洋
× 石黒, 洋× 山本, 明子× 中莖, みゆき× 衣, 蘭娟× 石黒, 真理子× 山口, 誠× 近藤, 志保× 持丸, 由香× Ishiguro, Hiroshi× Yamamoto, Akiko× Nakakuki, Miyuki× Yi, Lanjuan× Ishiguro, Mariko× Yamaguchi, Makoto× Kondo, Shiho× Mochimaru, Yuka |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Excretion of hypotonic sweat by eccrine sweat gland is achieved by re-absorption of NaCl by sweat duct which is an important function to prevent the salt loss and heat prostration. The Cl– transport by sweat duct is mediated by cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. CFTR is the causative gene for cystic fibrosis, an autosomal recessive genetic disease. CFTR functions as a cAMP-dependent anion channel localized in the apical membrane of various epithelia. Loss of function due to severe mutations in both alleles causes typical cystic fibrosis characterized by dehydrated, thick, and viscous luminal fluid/mucus in the respiratory and gastrointestinal tract, pancreatic duct, and vas deferens. Cystic fibrosis is the most common genetic disease in Caucasians (1 per ~3,000 births) but it is rare in the Asian population including Japanese (1 per ~1.5 million). A compound heterozygote of mutations/polymorphisms (causing a mild dysfunction of CFTR) involves a risk of developing CFTR-related diseases (or atypical cystic fibrosis) such as chronic pancreatitis and male infertility due to congenital bilateral absence of the vas deferens (CBAVD). Recent studies suggest that CFTR mutations/polymorphisms are frequently found in Japanese patients with chronic pancreatitis, CBAVD and diffuse panbronchiolitis. Cl– concentration in the sweat is a useful measure of CFTR function in human. The sweat [Cl–] in healthy subjects is correlated with ages. High levels (＞60 mM) of sweat [Cl–] suggest the dysfunction of CFTR. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | 名古屋大学総合保健体育科学センター | |||||
| 言語 | ja | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/njhpfs.35.1.9 | |||||
| ID登録タイプ | JaLC | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0289-5412 | |||||
| 書誌情報 |
ja : 総合保健体育科学 巻 35, 号 1, p. 9-15, 発行日 2012-03-30 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/20216 | |||||
| 識別子タイプ | HDL | |||||
