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RHOF PROMOTES MURINE MARGINAL ZONE B CELL DEVELOPMENT
https://doi.org/10.18999/nagjms.76.3-4.293
https://doi.org/10.18999/nagjms.76.3-4.293166c65b0-941f-4213-8224-a0839016f869
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
08_Kishimoto.pdf (26.9 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-09-05 | |||||
| タイトル | ||||||
| タイトル | RHOF PROMOTES MURINE MARGINAL ZONE B CELL DEVELOPMENT | |||||
| 言語 | en | |||||
| 著者 |
KISHIMOTO, MAYUKO
× KISHIMOTO, MAYUKO× MATSUDA, TAKENORI× YANASE, SHOUGO× KATSUMI, AKIRA× SUZUKI, NOBUAKI× IKEJIRI, MAKOTO× TAKAGI, AKIRA× IKAWA, MASAHITO× KOJIMA, TETSUHITO× KUNISHIMA, SHINJI× KIYOI, HITOSHI× NAOE, TOMOKI× MATSUSHITA, TADASHI× MARUYAMA, MITSUO |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | RhoF | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Rho GTPase family | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | B cell development | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Marginal Zone B cell | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | RhoF is a member of the Rho GTPase family that has been implicated in various cell functions including long filopodia formation, adhesion, and migration of cells. Although RhoF is expressed in lymphoid tissues, the roles of RhoF in B cell development remain largely unclear. On the other hand, other members of the Rho GTPase family, such as Cdc42, RhoA, and Rac, have been intensively studied and are known to be required for B cell development in the bone marrow and spleen. We hypothesized that RhoF is also involved in B cell development. To examine our hypothesis, we analyzed B cell development in RhoF knockout (KO) mice and found a significant reduction in marginal zone (MZ) B cells in the spleen, although T cell development in the thymus and spleen was not affected. Consistent with these results, the width of the MZ B cell region in the spleen was significantly reduced in the RhoF KO mice. However, the antigen-specific antibody titer of IgM and IgG3 after MZ B cell-specific antigen (T cell-independent antigen, type I) stimulation was not affected by RhoF deletion. Furthermore, we demonstrated that RhoF was dispensable for stromal cell-derived factor-1α- and B lymphocyte chemoattractant-induced B cell migration. These results suggest that RhoF promotes MZ B cell development in the spleen. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.76.3-4.293 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7634/7634.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 76, 号 3-4, p. 293-305, 発行日 2014-08 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/20548 | |||||
| 識別子タイプ | HDL | |||||
