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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 76(3-4)

RHOF PROMOTES MURINE MARGINAL ZONE B CELL DEVELOPMENT

https://doi.org/10.18999/nagjms.76.3-4.293
https://doi.org/10.18999/nagjms.76.3-4.293
166c65b0-941f-4213-8224-a0839016f869
名前 / ファイル ライセンス アクション
08_Kishimoto.pdf 08_Kishimoto.pdf (26.9 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2014-09-05
タイトル
タイトル RHOF PROMOTES MURINE MARGINAL ZONE B CELL DEVELOPMENT
著者 KISHIMOTO, MAYUKO

× KISHIMOTO, MAYUKO

WEKO 53546

KISHIMOTO, MAYUKO

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MATSUDA, TAKENORI

× MATSUDA, TAKENORI

WEKO 53547

MATSUDA, TAKENORI

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YANASE, SHOUGO

× YANASE, SHOUGO

WEKO 53548

YANASE, SHOUGO

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KATSUMI, AKIRA

× KATSUMI, AKIRA

WEKO 53549

KATSUMI, AKIRA

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SUZUKI, NOBUAKI

× SUZUKI, NOBUAKI

WEKO 53550

SUZUKI, NOBUAKI

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IKEJIRI, MAKOTO

× IKEJIRI, MAKOTO

WEKO 53551

IKEJIRI, MAKOTO

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TAKAGI, AKIRA

× TAKAGI, AKIRA

WEKO 53552

TAKAGI, AKIRA

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IKAWA, MASAHITO

× IKAWA, MASAHITO

WEKO 53553

IKAWA, MASAHITO

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KOJIMA, TETSUHITO

× KOJIMA, TETSUHITO

WEKO 53554

KOJIMA, TETSUHITO

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KUNISHIMA, SHINJI

× KUNISHIMA, SHINJI

WEKO 53555

KUNISHIMA, SHINJI

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KIYOI, HITOSHI

× KIYOI, HITOSHI

WEKO 53556

KIYOI, HITOSHI

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NAOE, TOMOKI

× NAOE, TOMOKI

WEKO 53557

NAOE, TOMOKI

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MATSUSHITA, TADASHI

× MATSUSHITA, TADASHI

WEKO 53558

MATSUSHITA, TADASHI

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MARUYAMA, MITSUO

× MARUYAMA, MITSUO

WEKO 53559

MARUYAMA, MITSUO

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キーワード
主題Scheme Other
主題 RhoF
キーワード
主題Scheme Other
主題 Rho GTPase family
キーワード
主題Scheme Other
主題 B cell development
キーワード
主題Scheme Other
主題 Marginal Zone B cell
抄録
内容記述 RhoF is a member of the Rho GTPase family that has been implicated in various cell functions including long filopodia formation, adhesion, and migration of cells. Although RhoF is expressed in lymphoid tissues, the roles of RhoF in B cell development remain largely unclear. On the other hand, other members of the Rho GTPase family, such as Cdc42, RhoA, and Rac, have been intensively studied and are known to be required for B cell development in the bone marrow and spleen. We hypothesized that RhoF is also involved in B cell development. To examine our hypothesis, we analyzed B cell development in RhoF knockout (KO) mice and found a significant reduction in marginal zone (MZ) B cells in the spleen, although T cell development in the thymus and spleen was not affected. Consistent with these results, the width of the MZ B cell region in the spleen was significantly reduced in the RhoF KO mice. However, the antigen-specific antibody titer of IgM and IgG3 after MZ B cell-specific antigen (T cell-independent antigen, type I) stimulation was not affected by RhoF deletion. Furthermore, we demonstrated that RhoF was dispensable for stromal cell-derived factor-1α- and B lymphocyte chemoattractant-induced B cell migration. These results suggest that RhoF promotes MZ B cell development in the spleen.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.76.3-4.293
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 76, 号 3-4, p. 293-305, 発行日 2014-08
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7634/7634.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/20548
識別子タイプ HDL
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