ログイン
言語:

WEKO3

  • トップ
  • コミュニティ
  • ランキング
AND
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "162706f3-2dc1-49b7-b025-b300d54946be"}, "_deposit": {"id": "18531", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "18531"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00018531"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "e1000310", "bibliographicPageStart": "e1000310", "bibliographicVolumeNumber": "5", "bibliographic_titles": [{"bibliographic_title": "PLOS Computational Biology"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Eukaryotic cells can move spontaneously without being guided by external cues. For such spontaneous movements, a variety of different modes have been observed, including the amoeboid-like locomotion with protrusion of multiple pseudopods, the keratocyte-like locomotion with a widely spread lamellipodium, cell division with two daughter cells crawling in opposite directions, and fragmentations of a cell to multiple pieces. Mutagenesis studies have revealed that cells exhibit these modes depending on which genes are deficient, suggesting that seemingly different modes are the manifestation of a common mechanism to regulate cell motion. In this paper, we propose a hypothesis that the positive feedback mechanism working through the inhomogeneous distribution of regulatory proteins underlies this variety of cell locomotion and cytofission. In this hypothesis, a set of regulatory proteins, which we call cortical factors, suppress actin polymerization. These suppressing factors are diluted at the extending front and accumulated at the retracting rear of cell, which establishes a cellular polarity and enhances the cell motility, leading to the further accumulation of cortical factors at the rear. Stochastic simulation of cell movement shows that the positive feedback mechanism of cortical factors stabilizes or destabilizes modes of movement and determines the cell migration pattern. The model predicts that the pattern is selected by changing the rate of formation of the actin-filament network or the threshold to initiate the network formation.", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "DOI", "subitem_identifier_uri": "http://dx.doi.org/10.1371/journal.pcbi.1000310"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/20617"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "PLOS"}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1553-734X", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nishimura, Shin I."}], "nameIdentifiers": [{"nameIdentifier": "53832", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ueda, Masahiro"}], "nameIdentifiers": [{"nameIdentifier": "53833", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sasai, Masaki"}], "nameIdentifiers": [{"nameIdentifier": "53834", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-21"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "journal_pcbi_1000310.pdf", "filesize": [{"value": "735.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 735300.0, "url": {"label": "journal_pcbi_1000310.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/18531/files/journal_pcbi_1000310.pdf"}, "version_id": "8d33c828-f5ce-4e44-bd7d-694ca4567f7c"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Cortical Factor Feedback Model for Cellular Locomotion and Cytofission", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Cortical Factor Feedback Model for Cellular Locomotion and Cytofission"}]}, "item_type_id": "10", "owner": "1", "path": ["320/321/322"], "permalink_uri": "http://hdl.handle.net/2237/20617", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2014-10-30"}, "publish_date": "2014-10-30", "publish_status": "0", "recid": "18531", "relation": {}, "relation_version_is_last": true, "title": ["Cortical Factor Feedback Model for Cellular Locomotion and Cytofission"], "weko_shared_id": null}
  1. B200 工学部/工学研究科
  2. B200a 雑誌掲載論文
  3. 学術雑誌

Cortical Factor Feedback Model for Cellular Locomotion and Cytofission

http://hdl.handle.net/2237/20617
145b241b-cfed-4bf8-81e1-076b76442605
名前 / ファイル ライセンス アクション
journal_pcbi_1000310.pdf journal_pcbi_1000310.pdf (735.3 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-10-30
タイトル
タイトル Cortical Factor Feedback Model for Cellular Locomotion and Cytofission
著者 Nishimura, Shin I.

× Nishimura, Shin I.

WEKO 53832

Nishimura, Shin I.

Search repository
Ueda, Masahiro

× Ueda, Masahiro

WEKO 53833

Ueda, Masahiro

Search repository
Sasai, Masaki

× Sasai, Masaki

WEKO 53834

Sasai, Masaki

Search repository
抄録
内容記述 Eukaryotic cells can move spontaneously without being guided by external cues. For such spontaneous movements, a variety of different modes have been observed, including the amoeboid-like locomotion with protrusion of multiple pseudopods, the keratocyte-like locomotion with a widely spread lamellipodium, cell division with two daughter cells crawling in opposite directions, and fragmentations of a cell to multiple pieces. Mutagenesis studies have revealed that cells exhibit these modes depending on which genes are deficient, suggesting that seemingly different modes are the manifestation of a common mechanism to regulate cell motion. In this paper, we propose a hypothesis that the positive feedback mechanism working through the inhomogeneous distribution of regulatory proteins underlies this variety of cell locomotion and cytofission. In this hypothesis, a set of regulatory proteins, which we call cortical factors, suppress actin polymerization. These suppressing factors are diluted at the extending front and accumulated at the retracting rear of cell, which establishes a cellular polarity and enhances the cell motility, leading to the further accumulation of cortical factors at the rear. Stochastic simulation of cell movement shows that the positive feedback mechanism of cortical factors stabilizes or destabilizes modes of movement and determines the cell migration pattern. The model predicts that the pattern is selected by changing the rate of formation of the actin-filament network or the threshold to initiate the network formation.
内容記述タイプ Abstract
出版者
出版者 PLOS
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
ISSN
収録物識別子タイプ ISSN
収録物識別子 1553-734X
書誌情報 PLOS Computational Biology

巻 5, 号 3, p. e1000310-e1000310, 発行日 2009-03
著者版フラグ
値 publisher
URI
識別子 http://dx.doi.org/10.1371/journal.pcbi.1000310
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/20617
識別子タイプ HDL
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 16:38:10.765286
Show All versions

Share

Mendeley CiteULike Twitter Facebook Print Addthis

Cite as

Export

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by CERN Data Centre & Invenio


Powered by CERN Data Centre & Invenio