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Cortical Factor Feedback Model for Cellular Locomotion and Cytofission
http://hdl.handle.net/2237/20617
145b241b-cfed-4bf8-81e1-076b76442605
名前 / ファイル | ライセンス | アクション | |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-10-30 | |||||
タイトル | ||||||
タイトル | Cortical Factor Feedback Model for Cellular Locomotion and Cytofission | |||||
著者 |
Nishimura, Shin I.
× Nishimura, Shin I.× Ueda, Masahiro× Sasai, Masaki |
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抄録 | ||||||
内容記述 | Eukaryotic cells can move spontaneously without being guided by external cues. For such spontaneous movements, a variety of different modes have been observed, including the amoeboid-like locomotion with protrusion of multiple pseudopods, the keratocyte-like locomotion with a widely spread lamellipodium, cell division with two daughter cells crawling in opposite directions, and fragmentations of a cell to multiple pieces. Mutagenesis studies have revealed that cells exhibit these modes depending on which genes are deficient, suggesting that seemingly different modes are the manifestation of a common mechanism to regulate cell motion. In this paper, we propose a hypothesis that the positive feedback mechanism working through the inhomogeneous distribution of regulatory proteins underlies this variety of cell locomotion and cytofission. In this hypothesis, a set of regulatory proteins, which we call cortical factors, suppress actin polymerization. These suppressing factors are diluted at the extending front and accumulated at the retracting rear of cell, which establishes a cellular polarity and enhances the cell motility, leading to the further accumulation of cortical factors at the rear. Stochastic simulation of cell movement shows that the positive feedback mechanism of cortical factors stabilizes or destabilizes modes of movement and determines the cell migration pattern. The model predicts that the pattern is selected by changing the rate of formation of the actin-filament network or the threshold to initiate the network formation. | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
出版者 | PLOS | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1553-734X | |||||
書誌情報 |
PLOS Computational Biology 巻 5, 号 3, p. e1000310-e1000310, 発行日 2009-03 |
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著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://dx.doi.org/10.1371/journal.pcbi.1000310 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/20617 | |||||
識別子タイプ | HDL |