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  1. B200 工学部/工学研究科
  2. B200a 雑誌掲載論文
  3. 学術雑誌

Unidirectional Brownian motion observed in an in silico single molecule experiment of an actomyosin motor

http://hdl.handle.net/2237/20619
http://hdl.handle.net/2237/20619
c75645c0-f09f-41fa-b23d-e08d3e5e9324
名前 / ファイル ライセンス アクション
PNAS-2010-Takano-7769-74.pdf PNAS-2010-Takano-7769-74.pdf (2.6 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-10-30
タイトル
タイトル Unidirectional Brownian motion observed in an in silico single molecule experiment of an actomyosin motor
言語 en
著者 Takano, Mitsunori

× Takano, Mitsunori

WEKO 53839

en Takano, Mitsunori

Search repository
Terada, Tomoki P.

× Terada, Tomoki P.

WEKO 53840

en Terada, Tomoki P.

Search repository
Sasai, Masaki

× Sasai, Masaki

WEKO 53841

en Sasai, Masaki

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 molecular machines
キーワード
主題Scheme Other
主題 molecular motors
キーワード
主題Scheme Other
主題 mechano-chemical coupling
キーワード
主題Scheme Other
主題 molecular dynamics simulation
キーワード
主題Scheme Other
主題 functional funnel
抄録
内容記述 The actomyosin molecular motor, the motor composed of myosin II and actin filament, is responsible for muscle contraction, converting chemical energy into mechanical work. Although recent single molecule and structural studies have shed new light on the energy-converting mechanism, the physical basis of the molecular-level mechanism remains unclear because of the experimental limitations. To provide a clue to resolve the controversy between the lever-arm mechanism and the Brownian ratchet-like mechanism, we here report an in silico single molecule experiment of an actomyosin motor. When we placed myosin on an actin filament and allowed myosin to move along the filament, we found that myosin exhibits a unidirectional Brownian motion along the filament. This unidirectionality was found to arise from the combination of a nonequilibrium condition realized by coupling to the ATP hydrolysis and a ratchet-like energy landscape inherent in the actin-myosin interaction along the filament, indicating that a Brownian ratchet-like mechanism contributes substantially to the energy conversion of this molecular motor.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 National Academy of Sciences
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1073/pnas.0911830107
ISSN
収録物識別子タイプ PISSN
収録物識別子 1091-6490
書誌情報 en : Proceedings of the National Academy of Sciences of the United States of America

巻 107, 号 17, p. 7769-7774, 発行日 2010-04
著者版フラグ
値 publisher
URI
識別子 http://dx.doi.org/10.1073/pnas.0911830107
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/20619
識別子タイプ HDL
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