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Unidirectional Brownian motion observed in an in silico single molecule experiment of an actomyosin motor
http://hdl.handle.net/2237/20619
http://hdl.handle.net/2237/20619c75645c0-f09f-41fa-b23d-e08d3e5e9324
名前 / ファイル | ライセンス | アクション |
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PNAS-2010-Takano-7769-74.pdf (2.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-10-30 | |||||
タイトル | ||||||
タイトル | Unidirectional Brownian motion observed in an in silico single molecule experiment of an actomyosin motor | |||||
言語 | en | |||||
著者 |
Takano, Mitsunori
× Takano, Mitsunori× Terada, Tomoki P.× Sasai, Masaki |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | molecular machines | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | molecular motors | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mechano-chemical coupling | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | molecular dynamics simulation | |||||
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主題Scheme | Other | |||||
主題 | functional funnel | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The actomyosin molecular motor, the motor composed of myosin II and actin filament, is responsible for muscle contraction, converting chemical energy into mechanical work. Although recent single molecule and structural studies have shed new light on the energy-converting mechanism, the physical basis of the molecular-level mechanism remains unclear because of the experimental limitations. To provide a clue to resolve the controversy between the lever-arm mechanism and the Brownian ratchet-like mechanism, we here report an in silico single molecule experiment of an actomyosin motor. When we placed myosin on an actin filament and allowed myosin to move along the filament, we found that myosin exhibits a unidirectional Brownian motion along the filament. This unidirectionality was found to arise from the combination of a nonequilibrium condition realized by coupling to the ATP hydrolysis and a ratchet-like energy landscape inherent in the actin-myosin interaction along the filament, indicating that a Brownian ratchet-like mechanism contributes substantially to the energy conversion of this molecular motor. | |||||
言語 | en | |||||
出版者 | ||||||
出版者 | National Academy of Sciences | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1073/pnas.0911830107 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1091-6490 | |||||
書誌情報 |
en : Proceedings of the National Academy of Sciences of the United States of America 巻 107, 号 17, p. 7769-7774, 発行日 2010-04 |
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著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://dx.doi.org/10.1073/pnas.0911830107 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/20619 | |||||
識別子タイプ | HDL |