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Protective Effects of Phyllanthus Emblica Leaf Extract on Sodium Arsenite-mediated Adverse Effects in Mice
https://doi.org/10.18999/nagjms.77.1-2.145
https://doi.org/10.18999/nagjms.77.1-2.145cc34bac9-0c92-4494-a025-2d3a6f21933a
名前 / ファイル | ライセンス | アクション |
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21_Sayed.pdf (258.5 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-02-26 | |||||
タイトル | ||||||
タイトル | Protective Effects of Phyllanthus Emblica Leaf Extract on Sodium Arsenite-mediated Adverse Effects in Mice | |||||
言語 | en | |||||
著者 |
SAYED, SADIA
× SAYED, SADIA× AHSAN, NAZMUL× KATO, MASASHI× OHGAMI, NOBUTAKA× RASHID, ABDUR× ANWARUL, AZIM AKHAND |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | sodium arsenite | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Phyllanthus emblica | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | growth retardation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mice | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antioxidant | |||||
抄録 | ||||||
内容記述 | Groundwater contamination of arsenic is the major cause of a serious health hazard in Bangladesh. No specific treatment is yet available to manage the large number of individuals exposed to arsenic. In this study, we evaluated the protective effects of Phyllanthus emblica (Indian gooseberry or Amla) leaf extract (PLE) on arsenic-mediated toxicity in experimental mice. Male Swiss albino mice were divided into three different groups (n=6/group). ‘Control’ mice received arsenic free water together with normal feed. Mice in the remaining two groups designated ‘SA’ and ‘SA+PLE’ were exposed to sodium arsenite (SA, 10 μg/g body weight/day) through drinking water in addition to receiving normal feed and PLE-supplemented feed, respectively. The weight gain of SA-exposed mice was decreased compared with the controls; however, this decrease in body weight gain was prevented when the feed was supplemented with PLE. A secondary effect of arsenic was enlargement of the liver, kidney and spleen of SA-group mice. Deposition of arsenic in those organs was demonstrated by ICP-MS. When PLE was supplemented in the feed the enlargement of the organs was minimized; however, the deposition of arsenic was not significantly reduced. These results indicated that PLE may not block arsenic deposition in tissue directly but rather may play a protective role to reduce arsenic-induced toxicity. Therefore, co-administration of PLE in arsenic-exposed animals might have a future therapeutic application for protecting against arsenic-mediated toxicity. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.77.1-2.145 | |||||
ID登録タイプ | JaLC | |||||
関連情報 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7712.html | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 77, 号 1-2, p. 145-153, 発行日 2015-02 |
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著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/21267 | |||||
識別子タイプ | HDL |