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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 77(1-2)

High Osmolarity Effect of Intravitreal Plasmin Enzyme on Rabbit Retina

https://doi.org/10.18999/nagjms.77.1-2.245
https://doi.org/10.18999/nagjms.77.1-2.245
095e5ba9-d7f3-430c-ac68-dbb6e4dc5b2e
名前 / ファイル ライセンス アクション
32_Asami.pdf 32_Asami.pdf (912.9 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-02-27
タイトル
タイトル High Osmolarity Effect of Intravitreal Plasmin Enzyme on Rabbit Retina
著者 ASAMI, TETSU

× ASAMI, TETSU

WEKO 56093

ASAMI, TETSU

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KACHI, SHU

× KACHI, SHU

WEKO 56094

KACHI, SHU

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USAMA, ALI MOHAMED

× USAMA, ALI MOHAMED

WEKO 56095

USAMA, ALI MOHAMED

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ITO, YASUKI

× ITO, YASUKI

WEKO 56096

ITO, YASUKI

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TERASAKI, HIROKO

× TERASAKI, HIROKO

WEKO 56097

TERASAKI, HIROKO

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キーワード
主題Scheme Other
主題 plasmin
キーワード
主題Scheme Other
主題 retinal thickness
キーワード
主題Scheme Other
主題 serous retinal detachment
キーワード
主題Scheme Other
主題 high osmolarity
キーワード
主題Scheme Other
主題 posterior vitreous detachment
抄録
内容記述 We conducted a study of the effect of intravitreal plasmin on retinal thickness in rabbits. Forty rabbit eyes were injected with 0.4, 1, 2, and 5 IU of plasmin (8 eyes/group). The same volume of BSS-plus® was injected in control eyes. Four eyes in each group underwent vitrectomy 60 minutes after the injections. The retinal thickness was measured in optical coherence tomographic (OCT) images before, 30 minutes, and 1 week after the injection. To study the effect of hyperosmolarity, 4 eyes received an injection of mannitol solution whose osmolarity was the same as the plasmin solutions. Thirty minutes after the plasmin injection, 4 eyes developed a serous retinal detachment (SRD). The mean retinal thickness including SRD was increased at 30 minutes in a dose-dependent way. The increase in eyes with 5 IU of plasmin was significantly greater than that in eyes with BSS-Plus® or 0.4 IU of plasmin (P = 0.0266, P = 0.0371, respectively). One week after the injection, SRD disappeared, and the mean retinal thickness decreased. The eyes injected with mannitol, the same osmolarity of 1, 2, 5 IU of plasmin, developed SRD at 30 minutes, and it disappeared after 1 week in all eyes. The results of this study demonstrated that an intravitreal injection of plasmin increases the retinal thickness in a dose-dependent way in rabbit eyes. The results with mannitol suggest that the increase in retinal thickness following plasmin is most likely caused by the hyperosmolarity of plasmin solution.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.77.1-2.245
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 77, 号 1-2, p. 245-252, 発行日 2015-02
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7712.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/21278
識別子タイプ HDL
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