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Rhabdoid Glioblastoma: An Aggressive Variety of Astrocytic Tumor
https://doi.org/10.18999/nagjms.77.1-2.321
https://doi.org/10.18999/nagjms.77.1-2.321fa98bd5b-9491-401f-995e-34df570c3fd0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
44_Momota_revised.pdf (428.3 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-02-27 | |||||
| タイトル | ||||||
| タイトル | Rhabdoid Glioblastoma: An Aggressive Variety of Astrocytic Tumor | |||||
| 言語 | en | |||||
| 著者 |
MOMOTA, HIROYUKI
× MOMOTA, HIROYUKI× OGINO, JIRO× TAKAHASHI, AKIRA× HASEGAWA, TADASHI× WAKABAYASHI, TOSHIHIKO |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | rhabdoid glioblastoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | astrocytic tumor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | INI1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | GFAP | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | adult | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Rhabdoid glioblastoma (RGBM) is rare, but the most malignant among astrocytic tumors. Accumulating evidence indicates its highly aggressive nature and distinct histopathological features. Here, we report a new case of RGBM and review previously reported cases of astrocytic tumors with rhabdoid components. We describe a 58-year-old man who presented with aphasia and right-sided weakness. Magnetic resonance imaging revealed a well-delineated intramedullary tumor in the left cerebral hemisphere. Partial resection of the tumor was performed. The tumor was histologically found to contain two distinct areas: a typical glioblastoma, and a rhabdoid component. Immunohistochemical analyses revealed expression of glial fibrillary acidic protein (GFAP) and focal loss of the INI1 protein in rhabdoid cells, although fluorescence in situ hybridization analysis showed no loss of the INI1 gene. Despite subsequent radiochemotherapy for the glioblastoma, the patient died 4.3 months after surgery. Our literature review illustrates the aggressive clinical course and histopathological features of these tumors with GFAP and INI1 expression. INI1 protein dysfunction may be a possible cause of the rhabdoid phenotype. Gross total resection of the tumor and intensive radiochemotherapy may lead to better survival outcomes. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | revised version upload : 2015-05-13 | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.77.1-2.321 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7712.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 77, 号 1-2, p. 321-328, 発行日 2015-02 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/21286 | |||||
| 識別子タイプ | HDL | |||||
