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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 77(1-2)

Rhabdoid Glioblastoma: An Aggressive Variety of Astrocytic Tumor

https://doi.org/10.18999/nagjms.77.1-2.321
https://doi.org/10.18999/nagjms.77.1-2.321
fa98bd5b-9491-401f-995e-34df570c3fd0
名前 / ファイル ライセンス アクション
44_Momota_revised.pdf 44_Momota_revised.pdf (428.3 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-02-27
タイトル
タイトル Rhabdoid Glioblastoma: An Aggressive Variety of Astrocytic Tumor
著者 MOMOTA, HIROYUKI

× MOMOTA, HIROYUKI

WEKO 56150

MOMOTA, HIROYUKI

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OGINO, JIRO

× OGINO, JIRO

WEKO 56151

OGINO, JIRO

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TAKAHASHI, AKIRA

× TAKAHASHI, AKIRA

WEKO 56152

TAKAHASHI, AKIRA

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HASEGAWA, TADASHI

× HASEGAWA, TADASHI

WEKO 56153

HASEGAWA, TADASHI

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WAKABAYASHI, TOSHIHIKO

× WAKABAYASHI, TOSHIHIKO

WEKO 56154

WAKABAYASHI, TOSHIHIKO

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キーワード
主題Scheme Other
主題 rhabdoid glioblastoma
キーワード
主題Scheme Other
主題 astrocytic tumor
キーワード
主題Scheme Other
主題 INI1
キーワード
主題Scheme Other
主題 GFAP
キーワード
主題Scheme Other
主題 adult
抄録
内容記述 Rhabdoid glioblastoma (RGBM) is rare, but the most malignant among astrocytic tumors. Accumulating evidence indicates its highly aggressive nature and distinct histopathological features. Here, we report a new case of RGBM and review previously reported cases of astrocytic tumors with rhabdoid components. We describe a 58-year-old man who presented with aphasia and right-sided weakness. Magnetic resonance imaging revealed a well-delineated intramedullary tumor in the left cerebral hemisphere. Partial resection of the tumor was performed. The tumor was histologically found to contain two distinct areas: a typical glioblastoma, and a rhabdoid component. Immunohistochemical analyses revealed expression of glial fibrillary acidic protein (GFAP) and focal loss of the INI1 protein in rhabdoid cells, although fluorescence in situ hybridization analysis showed no loss of the INI1 gene. Despite subsequent radiochemotherapy for the glioblastoma, the patient died 4.3 months after surgery. Our literature review illustrates the aggressive clinical course and histopathological features of these tumors with GFAP and INI1 expression. INI1 protein dysfunction may be a possible cause of the rhabdoid phenotype. Gross total resection of the tumor and intensive radiochemotherapy may lead to better survival outcomes.
内容記述タイプ Abstract
内容記述
内容記述 revised version upload : 2015-05-13
内容記述タイプ Other
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.77.1-2.321
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7712.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 77, 号 1-2, p. 321-328, 発行日 2015-02
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/21286
識別子タイプ HDL
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