{"_buckets": {"deposit": "8ce62aaa-b56a-4129-bb5e-9ae676c05a12"}, "_deposit": {"id": "2000203", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "2000203"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:02000203"}, "control_number": "2000203", "item_1615768549627": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_9_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021-02", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "61", "bibliographicPageStart": "51", "bibliographicVolumeNumber": "83", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "Increasing evidence indicates that enhanced peripheral carbonyl stress markers exist in subtype of schizophrenia, although it may not be the primary cause.\nThis study aimed to investigate whether plasma concentrations of methylglyoxal, 3-deoxy-glucosone, and glyoxal, which are reactive intermediates of protein metabolism in carbonyl stress, are changed in patients with schizophrenia and can function as potential biomarkers for schizophrenia with enhanced carbonyl stress.\nPlasma concentrations of these di-carbonyls were simultaneously estimated in 40 patients with schizo-phrenia and 40 healthy controls. As a result, no statistically significant differences were observed in mean plasma concentrations of three di-carbonyls between patients and controls. However, a remarkable increase in methylglyoxal concentrations was observed in four patients but not in controls. This increase was not found with regard to 3-deoxyglucosone and glyoxal both of patients and controls.\nOur correlation analysis showed that both the plasma methylglyoxal and glyoxal concentrations were significantly correlated with 3-deoxyglucosone concentrations in 40 patients and 40 controls. However, the plasma methylglyoxal concentrations did not show any significant correlation with the glyoxal concentra-tions in the patients or the controls. In four patients with extremely high methylglyoxal levels, the plasma methylglyoxal and glyoxal concentrations were not correlated to the 3-deoxyglucosone concentrations. Methylglyoxal is a physiological substrate of the glyoxalase system, and the accelerated accumulation of this compound lowers the glyoxalase I activity.\nThese results suggested that this increase in four patients with high methylglyoxal levels may indicate the presence of a subtype of chronic schizophrenia that is associated with enhanced carbonyl stress.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}, {"subitem_description": "This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/).", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_9_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University Graduate School of Medicine, School of Medicine", "subitem_publisher_language": "en"}]}, "item_9_relation_43": {"attribute_name": "\u95a2\u9023\u60c5\u5831", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/831.html", "subitem_relation_type_select": "URI"}}]}, "item_9_source_id_7": {"attribute_name": "\u53ce\u9332\u7269\u8b58\u5225\u5b50", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "PISSN"}, {"subitem_source_identifier": "2186-3326", "subitem_source_identifier_type": "EISSN"}]}, "item_access_right": {"attribute_name": "\u30a2\u30af\u30bb\u30b9\u6a29", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yoshioka, Shingo", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Odani, Hiroko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Furuhashi, Tadaaki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Tanaka, Tsutomu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ogawa, Toyoaki", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2021-05-31"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "05_Yoshioka.pdf", "filesize": [{"value": "750 KB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 750000.0, "url": {"label": "05_Yoshioka.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/2000203/files/05_Yoshioka.pdf"}, "version_id": "62bba098-9ba6-431a-8aa3-e47627001166"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "schizophrenia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "carbonyl stress", "subitem_subject_scheme": "Other"}, {"subitem_subject": "methylglyoxal", "subitem_subject_scheme": "Other"}, {"subitem_subject": "glyoxal", "subitem_subject_scheme": "Other"}, {"subitem_subject": "3-deoxyglucosone", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Increase in the peripheral blood methylglyoxal levels in 10% of hospitalized chronic schizophrenia patients", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Increase in the peripheral blood methylglyoxal levels in 10% of hospitalized chronic schizophrenia patients", "subitem_title_language": "en"}]}, "item_type_id": "40001", "owner": "17", "path": ["499/508/509/1622427158333"], "permalink_uri": "http://hdl.handle.net/2237/0002000203", "pubdate": {"attribute_name": "PubDate", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2021-05-31"}, "publish_date": "2021-05-31", "publish_status": "0", "recid": "2000203", "relation": {}, "relation_version_is_last": true, "title": ["Increase in the peripheral blood methylglyoxal levels in 10% of hospitalized chronic schizophrenia patients"], "weko_shared_id": -1}