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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 83(1)

Increase in the peripheral blood methylglyoxal levels in 10% of hospitalized chronic schizophrenia patients

https://doi.org/10.18999/nagjms.83.1.51
https://doi.org/10.18999/nagjms.83.1.51
748b2da0-eb23-45d3-8df9-d7f6afd73c31
名前 / ファイル ライセンス アクション
05_Yoshioka.pdf 05_Yoshioka.pdf (750 KB)
Item type itemtype_ver1(1)
公開日 2021-05-31
タイトル
タイトル Increase in the peripheral blood methylglyoxal levels in 10% of hospitalized chronic schizophrenia patients
言語 en
著者 Yoshioka, Shingo

× Yoshioka, Shingo

en Yoshioka, Shingo

Search repository
Odani, Hiroko

× Odani, Hiroko

en Odani, Hiroko

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Furuhashi, Tadaaki

× Furuhashi, Tadaaki

en Furuhashi, Tadaaki

Search repository
Tanaka, Tsutomu

× Tanaka, Tsutomu

en Tanaka, Tsutomu

Search repository
Ogawa, Toyoaki

× Ogawa, Toyoaki

en Ogawa, Toyoaki

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 schizophrenia
キーワード
主題Scheme Other
主題 carbonyl stress
キーワード
主題Scheme Other
主題 methylglyoxal
キーワード
主題Scheme Other
主題 glyoxal
キーワード
主題Scheme Other
主題 3-deoxyglucosone
内容記述
内容記述 Increasing evidence indicates that enhanced peripheral carbonyl stress markers exist in subtype of schizophrenia, although it may not be the primary cause.
This study aimed to investigate whether plasma concentrations of methylglyoxal, 3-deoxy-glucosone, and glyoxal, which are reactive intermediates of protein metabolism in carbonyl stress, are changed in patients with schizophrenia and can function as potential biomarkers for schizophrenia with enhanced carbonyl stress.
Plasma concentrations of these di-carbonyls were simultaneously estimated in 40 patients with schizo-phrenia and 40 healthy controls. As a result, no statistically significant differences were observed in mean plasma concentrations of three di-carbonyls between patients and controls. However, a remarkable increase in methylglyoxal concentrations was observed in four patients but not in controls. This increase was not found with regard to 3-deoxyglucosone and glyoxal both of patients and controls.
Our correlation analysis showed that both the plasma methylglyoxal and glyoxal concentrations were significantly correlated with 3-deoxyglucosone concentrations in 40 patients and 40 controls. However, the plasma methylglyoxal concentrations did not show any significant correlation with the glyoxal concentra-tions in the patients or the controls. In four patients with extremely high methylglyoxal levels, the plasma methylglyoxal and glyoxal concentrations were not correlated to the 3-deoxyglucosone concentrations. Methylglyoxal is a physiological substrate of the glyoxalase system, and the accelerated accumulation of this compound lowers the glyoxalase I activity.
These results suggested that this increase in four patients with high methylglyoxal levels may indicate the presence of a subtype of chronic schizophrenia that is associated with enhanced carbonyl stress.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/).
言語 en
内容記述タイプ Other
出版者
言語 en
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/nagjms.83.1.51
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/831.html
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0027-7622
収録物識別子
収録物識別子タイプ EISSN
収録物識別子 2186-3326
書誌情報 en : Nagoya Journal of Medical Science

巻 83, 号 1, p. 51-61, 発行日 2021-02
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