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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 83(2)

Odontogenic keratocysts are an important clue for diagnosing basal cell nevus syndrome

https://doi.org/10.18999/nagjms.83.2.393
https://doi.org/10.18999/nagjms.83.2.393
98a6f10f-f75c-4fb5-88d1-cc73712f9fef
名前 / ファイル ライセンス アクション
20_Kaibuchi.pdf 20_Kaibuchi.pdf (12.3 MB)
Item type itemtype_ver1(1)
公開日 2021-06-25
タイトル
タイトル Odontogenic keratocysts are an important clue for diagnosing basal cell nevus syndrome
言語 en
著者 Kaibuchi-Ando, Kaori

× Kaibuchi-Ando, Kaori

en Kaibuchi-Ando, Kaori

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Takeichi, Takuya

× Takeichi, Takuya

en Takeichi, Takuya

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Ito, Yasutoshi

× Ito, Yasutoshi

en Ito, Yasutoshi

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Takeuchi, So

× Takeuchi, So

en Takeuchi, So

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Yamashita, Yuta

× Yamashita, Yuta

en Yamashita, Yuta

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Yamada, Motohito

× Yamada, Motohito

en Yamada, Motohito

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Muro, Yoshinao

× Muro, Yoshinao

en Muro, Yoshinao

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Ogi, Tomoo

× Ogi, Tomoo

en Ogi, Tomoo

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Akiyama, Masashi

× Akiyama, Masashi

en Akiyama, Masashi

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 basal cell nevus syndrome
キーワード
主題Scheme Other
主題 mutation
キーワード
主題Scheme Other
主題 PTCH1
内容記述
内容記述 Basal cell nevus syndrome (BCNS) is an autosomal dominant skin disorder characterized by multiple basal cell nevi. Patients with BCNS tend to develop basal cell carcinoma (BCC) and frequently show skeletal abnormalities. Most cases of BCNS are caused by mutations in patched 1 (PTCH1). PTCH1encodes a transmembrane receptor protein for the secreted molecule sonic hedgehog, which plays a key role in the development of animals ranging from insects to mammals. We analyzed two Japanese BCNS patients from two independent families. Both of our patients had multiple jaw keratocysts. In one patient, these were the key to noticing his BCNS, as he had no skin tumors. The early detection of PTCH1mutations would enable BCNS patients to be carefully followed up for the occurrence of BCC. The diagnosis of BCC at the early stage leads to prompt surgical treatments, resulting in a good prognosis. The present cases suggest that keratocysts of the jaw might be an important clue for diagnosing BCNS.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/).
This study was also supported in part by JSPS KAKENHI Grant Number 18H02832 to M.A. and 20K08648 to T.T.
言語 en
内容記述タイプ Other
出版者
言語 en
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/nagjms.83.2.393
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/832.html
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0027-7622
収録物識別子
収録物識別子タイプ EISSN
収録物識別子 2186-3326
書誌情報 en : Nagoya Journal of Medical Science

巻 83, 号 2, p. 393-396, 発行日 2021-05
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