{"_buckets": {"deposit": "c0d12ed7-2382-40b5-aed6-6e833ec29347"}, "_deposit": {"id": "2001444", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2001444"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:02001444", "sets": ["1631753421512"]}, "author_link": [], "control_number": "2001444", "item_1615768549627": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_1615768833594": {"attribute_name": "助成情報", "attribute_value_mlt": [{"subitem_award_numbers": {"subitem_award_number": "18H02628", "subitem_award_uri": "https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02628/"}, "subitem_award_titles": [{"subitem_award_title": "スフィンゴ糖脂質と膜分子との複合体による細胞膜と微小環境のシグナル制御機構の解明", "subitem_award_title_language": "ja"}], "subitem_funder_names": [{"subitem_funder_name": "日本学術振興会", "subitem_funder_name_language": "ja"}, {"subitem_funder_name": "Japan Society for the Promotion of Science", "subitem_funder_name_language": "en"}]}, {"subitem_award_numbers": {"subitem_award_number": "19K22518", "subitem_award_uri": "https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22518/"}, "subitem_award_titles": [{"subitem_award_title": "細胞外分泌小胞における糖鎖と膜分子のクラスター形成による微小環境制御の動態解明", "subitem_award_title_language": "ja"}], "subitem_funder_names": [{"subitem_funder_name": "日本学術振興会", "subitem_funder_name_language": "ja"}, {"subitem_funder_name": "Japan Society for the Promotion of Science", "subitem_funder_name_language": "en"}]}]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "549", "bibliographicPageStart": "535", "bibliographicVolumeNumber": "83", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Ganglioside GD3/GD2 are over-expressed in various neuroectoderm-derived tumors. Previous studies indicated that GD3 is involved in the enhancement of cancer properties such as rapid growth and increased invasiveness. However, little is known about the functions of GD3/GD2 in glioma cells and glioma micro- environments. To clarify the functions of GD3/GD2 in gliomas, we used a mouse glioma model based on the RCAS/Gtv-a system. At first, we compared the gliomas size between wild-type (WT) and GD3 synthase (GD3S) knockout (KO) mice, showing a less malignant histology and slower tumor growth in GD3S-KO mice than in WT mice. Immunohistochemistry of glioma sections from WT and GD3S-KO mice revealed that reactive microglia/macrophages showed different localization patterns between the two genetic types of mice. CD68+ cells were more frequently stained inside glioma tissues of GD3S-KO mice, while they were stained mainly around glioma tissues in WT mice. The number of CD68+ cells markedly increased in tumor tissues of GD3S-KO mice at 2 weeks after injection of transfectant DF-1 cells. Furthermore, CD68+ cells in GD3S(-/-) glioma tissues expressed higher levels of inducible nitric oxide synthase. We observed higher expression levels of pro-inflammatory cytokine genes in primary-cultured glioma cells of WT mice than in GD3S-KO mice. DNA microarray data also revealed differential expression levels of various cytokines and chemokines in glioma tissues between WT and GD3S-KO mice. These results suggest that expression of GD3S allows glioma cells to promote polarization of microglia/macrophages towards M2-like phenotypes by modulating the expression levels of chemokines and cytokines.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}, {"subitem_description": "This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/).", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.83.3.535", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University Graduate School of Medicine, School of Medicine", "subitem_publisher_language": "en"}]}, "item_9_relation_43": {"attribute_name": "関連情報", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/833.html", "subitem_relation_type_select": "URI"}}]}, "item_9_source_id_7": {"attribute_name": "収録物識別子", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "PISSN"}, {"subitem_source_identifier": "2186-3326", "subitem_source_identifier_type": "EISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Zhang, Pu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ohkawa, Yuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yamamoto, Satoko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Momota, Hiroyuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kato, Akira", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kaneko, Kei", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Natsume, Atsushi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Farhana, Yesmin", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ohmi, Yuhsuke", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Okajima, Tetsuya", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Bhuiyan, Robiul H.", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Wakabayashi, Toshihiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Furukawa, Keiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Furukawa, Koichi", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2021-09-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "11_Zhang.pdf", "filesize": [{"value": "2.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "application/pdf", "size": 2600000.0, "url": {"objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/2001444/files/11_Zhang.pdf"}, "version_id": "96ffb7d6-b797-4cd8-b969-d6bc30c6282a"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "glioma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ganglioside GD3 synthase", "subitem_subject_scheme": "Other"}, {"subitem_subject": "knockout", "subitem_subject_scheme": "Other"}, {"subitem_subject": "microglia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tumor environment", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity", "subitem_title_language": "en"}]}, "item_type_id": "40001", "owner": "1", "path": ["1631753421512"], "permalink_uri": "https://doi.org/10.18999/nagjms.83.3.535", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2021-09-16"}, "publish_date": "2021-09-16", "publish_status": "0", "recid": "2001444", "relation": {}, "relation_version_is_last": true, "title": ["St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity"], "weko_shared_id": -1}