ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "c0d12ed7-2382-40b5-aed6-6e833ec29347"}, "_deposit": {"id": "2001444", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2001444"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:02001444", "sets": ["1631753421512"]}, "author_link": [], "control_number": "2001444", "item_1615768549627": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_1615768833594": {"attribute_name": "助成情報", "attribute_value_mlt": [{"subitem_award_numbers": {"subitem_award_number": "18H02628", "subitem_award_uri": "https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02628/"}, "subitem_award_titles": [{"subitem_award_title": "スフィンゴ糖脂質と膜分子との複合体による細胞膜と微小環境のシグナル制御機構の解明", "subitem_award_title_language": "ja"}], "subitem_funder_names": [{"subitem_funder_name": "日本学術振興会", "subitem_funder_name_language": "ja"}, {"subitem_funder_name": "Japan Society for the Promotion of Science", "subitem_funder_name_language": "en"}]}, {"subitem_award_numbers": {"subitem_award_number": "19K22518", "subitem_award_uri": "https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22518/"}, "subitem_award_titles": [{"subitem_award_title": "細胞外分泌小胞における糖鎖と膜分子のクラスター形成による微小環境制御の動態解明", "subitem_award_title_language": "ja"}], "subitem_funder_names": [{"subitem_funder_name": "日本学術振興会", "subitem_funder_name_language": "ja"}, {"subitem_funder_name": "Japan Society for the Promotion of Science", "subitem_funder_name_language": "en"}]}]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "549", "bibliographicPageStart": "535", "bibliographicVolumeNumber": "83", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Ganglioside GD3/GD2 are over-expressed in various neuroectoderm-derived tumors. Previous studies indicated that GD3 is involved in the enhancement of cancer properties such as rapid growth and increased invasiveness. However, little is known about the functions of GD3/GD2 in glioma cells and glioma micro- environments. To clarify the functions of GD3/GD2 in gliomas, we used a mouse glioma model based on the RCAS/Gtv-a system. At first, we compared the gliomas size between wild-type (WT) and GD3 synthase (GD3S) knockout (KO) mice, showing a less malignant histology and slower tumor growth in GD3S-KO mice than in WT mice. Immunohistochemistry of glioma sections from WT and GD3S-KO mice revealed that reactive microglia/macrophages showed different localization patterns between the two genetic types of mice. CD68+ cells were more frequently stained inside glioma tissues of GD3S-KO mice, while they were stained mainly around glioma tissues in WT mice. The number of CD68+ cells markedly increased in tumor tissues of GD3S-KO mice at 2 weeks after injection of transfectant DF-1 cells. Furthermore, CD68+ cells in GD3S(-/-) glioma tissues expressed higher levels of inducible nitric oxide synthase. We observed higher expression levels of pro-inflammatory cytokine genes in primary-cultured glioma cells of WT mice than in GD3S-KO mice. DNA microarray data also revealed differential expression levels of various cytokines and chemokines in glioma tissues between WT and GD3S-KO mice. These results suggest that expression of GD3S allows glioma cells to promote polarization of microglia/macrophages towards M2-like phenotypes by modulating the expression levels of chemokines and cytokines.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}, {"subitem_description": "This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/).", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.83.3.535", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University Graduate School of Medicine, School of Medicine", "subitem_publisher_language": "en"}]}, "item_9_relation_43": {"attribute_name": "関連情報", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/833.html", "subitem_relation_type_select": "URI"}}]}, "item_9_source_id_7": {"attribute_name": "収録物識別子", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "PISSN"}, {"subitem_source_identifier": "2186-3326", "subitem_source_identifier_type": "EISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Zhang, Pu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ohkawa, Yuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yamamoto, Satoko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Momota, Hiroyuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kato, Akira", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kaneko, Kei", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Natsume, Atsushi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Farhana, Yesmin", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ohmi, Yuhsuke", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Okajima, Tetsuya", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Bhuiyan, Robiul H.", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Wakabayashi, Toshihiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Furukawa, Keiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Furukawa, Koichi", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2021-09-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "11_Zhang.pdf", "filesize": [{"value": "2.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "application/pdf", "size": 2600000.0, "url": {"objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/2001444/files/11_Zhang.pdf"}, "version_id": "96ffb7d6-b797-4cd8-b969-d6bc30c6282a"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "glioma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ganglioside GD3 synthase", "subitem_subject_scheme": "Other"}, {"subitem_subject": "knockout", "subitem_subject_scheme": "Other"}, {"subitem_subject": "microglia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tumor environment", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity", "subitem_title_language": "en"}]}, "item_type_id": "40001", "owner": "1", "path": ["1631753421512"], "permalink_uri": "https://doi.org/10.18999/nagjms.83.3.535", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2021-09-16"}, "publish_date": "2021-09-16", "publish_status": "0", "recid": "2001444", "relation": {}, "relation_version_is_last": true, "title": ["St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity"], "weko_shared_id": -1}
  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 83(3)

St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity

https://doi.org/10.18999/nagjms.83.3.535
https://doi.org/10.18999/nagjms.83.3.535
4ddfb0b0-e91e-40d5-aaa5-9d55ca25274e
名前 / ファイル ライセンス アクション
11_Zhang.pdf 11_Zhang.pdf (2.6 MB)
Item type itemtype_ver1(1)
公開日 2021-09-16
タイトル
タイトル St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity
言語 en
著者 Zhang, Pu

× Zhang, Pu

en Zhang, Pu

Search repository
Ohkawa, Yuki

× Ohkawa, Yuki

en Ohkawa, Yuki

Search repository
Yamamoto, Satoko

× Yamamoto, Satoko

en Yamamoto, Satoko

Search repository
Momota, Hiroyuki

× Momota, Hiroyuki

en Momota, Hiroyuki

Search repository
Kato, Akira

× Kato, Akira

en Kato, Akira

Search repository
Kaneko, Kei

× Kaneko, Kei

en Kaneko, Kei

Search repository
Natsume, Atsushi

× Natsume, Atsushi

en Natsume, Atsushi

Search repository
Farhana, Yesmin

× Farhana, Yesmin

en Farhana, Yesmin

Search repository
Ohmi, Yuhsuke

× Ohmi, Yuhsuke

en Ohmi, Yuhsuke

Search repository
Okajima, Tetsuya

× Okajima, Tetsuya

en Okajima, Tetsuya

Search repository
Bhuiyan, Robiul H.

× Bhuiyan, Robiul H.

en Bhuiyan, Robiul H.

Search repository
Wakabayashi, Toshihiko

× Wakabayashi, Toshihiko

en Wakabayashi, Toshihiko

Search repository
Furukawa, Keiko

× Furukawa, Keiko

en Furukawa, Keiko

Search repository
Furukawa, Koichi

× Furukawa, Koichi

en Furukawa, Koichi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 glioma
キーワード
主題Scheme Other
主題 ganglioside GD3 synthase
キーワード
主題Scheme Other
主題 knockout
キーワード
主題Scheme Other
主題 microglia
キーワード
主題Scheme Other
主題 tumor environment
内容記述
内容記述 Ganglioside GD3/GD2 are over-expressed in various neuroectoderm-derived tumors. Previous studies indicated that GD3 is involved in the enhancement of cancer properties such as rapid growth and increased invasiveness. However, little is known about the functions of GD3/GD2 in glioma cells and glioma micro- environments. To clarify the functions of GD3/GD2 in gliomas, we used a mouse glioma model based on the RCAS/Gtv-a system. At first, we compared the gliomas size between wild-type (WT) and GD3 synthase (GD3S) knockout (KO) mice, showing a less malignant histology and slower tumor growth in GD3S-KO mice than in WT mice. Immunohistochemistry of glioma sections from WT and GD3S-KO mice revealed that reactive microglia/macrophages showed different localization patterns between the two genetic types of mice. CD68+ cells were more frequently stained inside glioma tissues of GD3S-KO mice, while they were stained mainly around glioma tissues in WT mice. The number of CD68+ cells markedly increased in tumor tissues of GD3S-KO mice at 2 weeks after injection of transfectant DF-1 cells. Furthermore, CD68+ cells in GD3S(-/-) glioma tissues expressed higher levels of inducible nitric oxide synthase. We observed higher expression levels of pro-inflammatory cytokine genes in primary-cultured glioma cells of WT mice than in GD3S-KO mice. DNA microarray data also revealed differential expression levels of various cytokines and chemokines in glioma tissues between WT and GD3S-KO mice. These results suggest that expression of GD3S allows glioma cells to promote polarization of microglia/macrophages towards M2-like phenotypes by modulating the expression levels of chemokines and cytokines.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/).
言語 en
内容記述タイプ Other
出版者
言語 en
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/nagjms.83.3.535
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/833.html
助成情報
助成機関名 日本学術振興会
言語 ja
助成機関名 Japan Society for the Promotion of Science
言語 en
研究課題番号URI https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02628/
研究課題番号 18H02628
研究課題名 スフィンゴ糖脂質と膜分子との複合体による細胞膜と微小環境のシグナル制御機構の解明
言語 ja
助成情報
助成機関名 日本学術振興会
言語 ja
助成機関名 Japan Society for the Promotion of Science
言語 en
研究課題番号URI https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22518/
研究課題番号 19K22518
研究課題名 細胞外分泌小胞における糖鎖と膜分子のクラスター形成による微小環境制御の動態解明
言語 ja
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0027-7622
収録物識別子
収録物識別子タイプ EISSN
収録物識別子 2186-3326
書誌情報 en : Nagoya Journal of Medical Science

巻 83, 号 3, p. 535-549, 発行日 2021-08
戻る
0
views
See details
Views

Versions

Ver.1 2021-09-16 01:41:22.862249
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3