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Previous studies indicated that GD3 is involved in the enhancement of cancer properties such as rapid growth and increased invasiveness. However, little is known about the functions of GD3/GD2 in glioma cells and glioma micro- environments. To clarify the functions of GD3/GD2 in gliomas, we used a mouse glioma model based on the RCAS/Gtv-a system. At first, we compared the gliomas size between wild-type (WT) and GD3 synthase (GD3S) knockout (KO) mice, showing a less malignant histology and slower tumor growth in GD3S-KO mice than in WT mice. Immunohistochemistry of glioma sections from WT and GD3S-KO mice revealed that reactive microglia/macrophages showed different localization patterns between the two genetic types of mice. CD68+ cells were more frequently stained inside glioma tissues of GD3S-KO mice, while they were stained mainly around glioma tissues in WT mice. The number of CD68+ cells markedly increased in tumor tissues of GD3S-KO mice at 2 weeks after injection of transfectant DF-1 cells. Furthermore, CD68+ cells in GD3S(-/-) glioma tissues expressed higher levels of inducible nitric oxide synthase. We observed higher expression levels of pro-inflammatory cytokine genes in primary-cultured glioma cells of WT mice than in GD3S-KO mice. DNA microarray data also revealed differential expression levels of various cytokines and chemokines in glioma tissues between WT and GD3S-KO mice. These results suggest that expression of GD3S allows glioma cells to promote polarization of microglia/macrophages towards M2-like phenotypes by modulating the expression levels of chemokines and cytokines.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}, {"subitem_description": "This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/).", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_9_identifier_registration": {"attribute_name": "ID\u767b\u9332", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.83.3.535", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University Graduate School of Medicine, School of Medicine", "subitem_publisher_language": "en"}]}, "item_9_relation_43": {"attribute_name": "\u95a2\u9023\u60c5\u5831", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/833.html", "subitem_relation_type_select": "URI"}}]}, "item_9_source_id_7": {"attribute_name": "\u53ce\u9332\u7269\u8b58\u5225\u5b50", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "PISSN"}, {"subitem_source_identifier": "2186-3326", "subitem_source_identifier_type": "EISSN"}]}, "item_access_right": {"attribute_name": "\u30a2\u30af\u30bb\u30b9\u6a29", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Zhang, Pu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ohkawa, Yuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yamamoto, Satoko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Momota, Hiroyuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kato, Akira", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kaneko, Kei", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Natsume, Atsushi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Farhana, Yesmin", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ohmi, Yuhsuke", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Okajima, Tetsuya", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Bhuiyan, Robiul H.", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Wakabayashi, Toshihiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Furukawa, Keiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Furukawa, Koichi", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2021-09-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "11_Zhang.pdf", "filesize": [{"value": "2.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "application/pdf", "size": 2600000.0, "url": {"objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/2001444/files/11_Zhang.pdf"}, "version_id": "96ffb7d6-b797-4cd8-b969-d6bc30c6282a"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "glioma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ganglioside GD3 synthase", "subitem_subject_scheme": "Other"}, {"subitem_subject": "knockout", "subitem_subject_scheme": "Other"}, {"subitem_subject": "microglia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tumor environment", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity", "subitem_title_language": "en"}]}, "item_type_id": "40001", "owner": "1", "path": ["499/508/509/1631753421512"], "permalink_uri": "https://doi.org/10.18999/nagjms.83.3.535", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2021-09-16"}, "publish_date": "2021-09-16", "publish_status": "0", "recid": "2001444", "relation": {}, "relation_version_is_last": true, "title": ["St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity"], "weko_shared_id": -1}