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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

The prebiotic fiber inulin ameliorates cardiac, adipose tissue, and hepatic pathology, but exacerbates hypertriglyceridemia in rats with metabolic syndrome

http://hdl.handle.net/2237/0002001530
http://hdl.handle.net/2237/0002001530
bf9856bf-b328-4e04-a7ae-476f158284f7
名前 / ファイル ライセンス アクション
Merged_File_containing_manuscript_text_and_5_Figure Merged_File_containing_manuscript_text_and_5_Figure files_KN.pdf (1.3 MB)
Item type itemtype_ver1(1)
公開日 2021-10-18
タイトル
タイトル The prebiotic fiber inulin ameliorates cardiac, adipose tissue, and hepatic pathology, but exacerbates hypertriglyceridemia in rats with metabolic syndrome
言語 en
著者 Komatsu, Yuki

× Komatsu, Yuki

en Komatsu, Yuki

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Aoyama, Kiyoshi

× Aoyama, Kiyoshi

en Aoyama, Kiyoshi

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Yoneda, Mamoru

× Yoneda, Mamoru

en Yoneda, Mamoru

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Ashikawa, Sao

× Ashikawa, Sao

en Ashikawa, Sao

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Nakano, Shiho

× Nakano, Shiho

en Nakano, Shiho

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Kawai, Yumeno

× Kawai, Yumeno

en Kawai, Yumeno

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Cui, Xixi

× Cui, Xixi

en Cui, Xixi

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Furukawa, Nozomi

× Furukawa, Nozomi

en Furukawa, Nozomi

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Ikeda, Katsuhide

× Ikeda, Katsuhide

en Ikeda, Katsuhide

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Nagata, Kohzo

× Nagata, Kohzo

en Nagata, Kohzo

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 (c)American Physiological Society
内容記述
内容記述 Prebiotics ameliorate dysbiosis and influence metabolism and the immune system, but their effects on cardiovascular complications in metabolic disorders remain largely unknown. We here investigated the effects of the soluble fiber inulin on cardiac, adipose tissue, and hepatic pathology as well as on metabolic disorders in DahlS.Z-Lepr^fa/Lepr^fa (DS/obese) rats, an animal model of metabolic syndrome (MetS). DS/obese rats and their homozygous lean (DahlS.Z-Lepr^+/Lepr^+, or DS/lean) littermate controls were fed a purified diet containing 5% or 20% inulin from 9 to 13 wk of age. The high-fiber diet ameliorated hypertension, left ventricular inflammation, fibrosis and diastolic dysfunction; attenuated adipose tissue inflammation and fibrosis; and alleviated the elevation of interleukin-6 levels, without affecting insulin resistance, in DS/obese rats. In addition, high fiber intake ameliorated lipid accumulation, inflammation, and fibrosis; attenuated the reduction in AMPK activity; upregulated sterol regulatory element-binding protein-1c gene expression; and increased the expression of microsomal triglyceride transfer protein gene in the liver of DS/obese rats. It also mitigated increases in total and non-high-density lipoprotein cholesterol levels but increased the triglyceride concentration in serum in these rats. None of these parameters were affected by high dietary fiber in DS/lean rats. The proportion of regulatory T cells in adipose tissue was influenced by dietary fiber but not by genotype. Our results indicate that inulin exacerbates hypertriglyceridemia but alleviates hypertension and cardiac injury as well as adipose tissue and hepatic pathology in MetS rats.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 American Physiological Society
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1152/ajpheart.00657.2020
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0363-6135
書誌情報 en : American Journal of Physiology-Heart and Circulatory Physiology

巻 320, 号 1, p. H281-H295, 発行日 2021-01-15
ファイル公開日
日付 2022-01-15
日付タイプ Available
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