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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

A simple method to distinguish residual elotuzumab from monoclonal paraprotein in immunofixation assays for multiple myeloma patients

http://hdl.handle.net/2237/0002001637
http://hdl.handle.net/2237/0002001637
e4579ff5-303c-4a00-a5d5-50acbec23995
名前 / ファイル ライセンス アクション
IJH_R1.pdf IJH_R1.pdf (554 KB)
Item type itemtype_ver1(1)
公開日 2021-11-22
タイトル
タイトル A simple method to distinguish residual elotuzumab from monoclonal paraprotein in immunofixation assays for multiple myeloma patients
言語 en
著者 Chen, Shurui

× Chen, Shurui

en Chen, Shurui

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Kiguchi, Toru

× Kiguchi, Toru

en Kiguchi, Toru

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Nagata, Yasuyuki

× Nagata, Yasuyuki

en Nagata, Yasuyuki

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Tamai, Yotaro

× Tamai, Yotaro

en Tamai, Yotaro

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Ikeda, Takeshi

× Ikeda, Takeshi

en Ikeda, Takeshi

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Kajiya, Ryoko

× Kajiya, Ryoko

en Kajiya, Ryoko

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Ono, Takaaki

× Ono, Takaaki

en Ono, Takaaki

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Sugiyama, Daisuke

× Sugiyama, Daisuke

en Sugiyama, Daisuke

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Nishikawa, Hiroyoshi

× Nishikawa, Hiroyoshi

en Nishikawa, Hiroyoshi

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Akatsuka, Yoshiki

× Akatsuka, Yoshiki

en Akatsuka, Yoshiki

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 Elotuzumab
キーワード
主題Scheme Other
主題 Immunofixation electrophoresis
キーワード
主題Scheme Other
主題 Monoclonal antibody
キーワード
主題Scheme Other
主題 Multiple myeloma
キーワード
主題Scheme Other
主題 Therapeutic
内容記述
内容記述 Negative immunofixation electrophoresis (IFE) of serum and/or urine is a diagnostic marker for determining a complete response (CR) after immunotherapy for multiple myeloma (MM). However, residual therapeutic antibodies such as elotuzumab (IgG-κ), can compromise IFE evaluation when the affected immunoglobulins belong to the same IgG-κ subclass. We thus sought to develop a simple and rapid method to treat patient serum before IFE to distinguish the residual elotuzumab. Serum samples from patients receiving elotuzumab were treated with a predetermined amount of soluble signaling lymphocyte activation molecule F7 (SLAMF7) protein and then subjected to conventional IFE testing. We tested our method in samples from 12 patients. The IgG-κ band in IFE disappeared or shifted after elotuzumab treatment in four patients with no bone marrow minimal residual disease and normalized free light chain, whereas seven patients with any sign of residual MM showed a remaining IgG-κ band after treatment. One-hour incubation of samples with 6–9 molar excess soluble SLAMF7 before IFE was sufficient to distinguish residual elotuzumab in 11 of 12 samples. This simple method does not require special reagents, can be performed in most clinical laboratories, and enables differentiation between patients with a CR and those requiring further treatment.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s12185-021-03088-9
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0925-5710
書誌情報 en : International Journal of Hematology

巻 113, 号 4, p. 473-479, 発行日 2021-04
ファイル公開日
日付 2022-04-01
日付タイプ Available
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