Item type |
itemtype_ver1(1) |
公開日 |
2021-12-03 |
タイトル |
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タイトル |
Hypoalbuminemia is related to endothelial dysfunction resulting from oxidative stress in parturients with preeclampsia |
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言語 |
en |
著者 |
Saitou, Takuya
Watanabe, Kazushi
Kinoshita, Hiroyuki
Iwasaki, Ai
Owaki, Yuki
Matsushita, Hiroshi
Wakatsuki, Akihiko
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利 |
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言語 |
en |
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権利情報Resource |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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権利情報 |
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
FMD |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
gestational hypertension |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
human serum albumin |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
oxidative stress |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
preeclampsia |
内容記述 |
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内容記述 |
Serum albumin levels are inversely related with oxidative stress, but positively related with endothelial function, in pregnant women. However, it is unclear whether hypoalbuminemia in pregnant women with preeclampsia (PE) increases the production of oxygen-derived free radicals and impacts endothelial function. The present study aimed to assess the relationship between serum albumin, oxidative stress, and endothelial dysfunction in pregnant women with PE. A total of 75 women with control pregnancy (Control group, n = 30), PE (PE group, n = 24), or gestational hypertension (GH) (GH group, n = 21) were enrolled. We assessed serum albumin levels, diacron-reactive oxygen metabolites (d-ROMs) as an oxygen-derived free radical marker, and flow-mediated dilation (FMD) as a readout for vascular endothelial function during the gestational period and at one month after delivery. During the gestational period, FMD was lower, but d-ROM levels were higher, in the PE and GH groups compared with the Control group. Serum albumin levels were lower in the PE group compared with the Control and GH groups. d-ROM levels were inversely correlated with serum albumin levels (r = –0.54, p < 0.05) and FMD (r = –0.56, p < 0.05) in the PE group, and negatively correlated with FMD, but not serum albumin levels, in the GH group. Serum levels of d-ROMs and albumin, as well as FMD, were similar between groups after delivery. Our findings suggest that reduced serum albumin levels enhance the production of oxygen-derived free radicals, resulting in impaired maternal vascular endothelial function in parturients with PE. |
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言語 |
en |
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内容記述タイプ |
Abstract |
出版者 |
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言語 |
en |
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出版者 |
Nagoya University Graduate School of Medicine, School of Medicine |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
departmental bulletin paper |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
ID登録 |
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ID登録 |
10.18999/nagjms.83.4.741 |
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ID登録タイプ |
JaLC |
関連情報 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
URI |
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関連識別子 |
https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/834.html |
収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0027-7622 |
収録物識別子 |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2186-3326 |
書誌情報 |
en : Nagoya Journal of Medical Science
巻 83,
号 4,
p. 741-748,
発行日 2021-11
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