Item type |
itemtype_ver1(1) |
公開日 |
2021-12-03 |
タイトル |
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タイトル |
Long-term outcomes of the partial splenectomy for hypersplenism after portoenterostomy of patients with biliary atresia |
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言語 |
en |
著者 |
Tainaka, Takahisa
Hinoki, Akinari
Tanaka, Yujiro
Shirota, Chiyoe
Sumida, Wataru
Yokota, Kazuki
Makita, Satoshi
Oshima, Kazuo
Amano, Hizuru
Takimoto, Aitaro
Kano, Yoko
Uchida, Hiroo
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利 |
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言語 |
en |
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権利情報Resource |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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権利情報 |
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
biliary atresia |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
partial splenectomy |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
portal hypertension |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
splenomegaly |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
hypersplenism |
内容記述 |
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内容記述 |
Massive splenomegaly and hypersplenism in patients with biliary atresia after Kasai portoenterostomy were treated with partial splenic embolization or total splenectomy. We performed partial splenectomy to reduce the complications of partial splenic embolization and avoid overwhelming post-splenectomy infection. This study aimed to evaluate the long-term effects of partial splenectomy for hypersplenism on postoperative liver and spleen function in patients with biliary atresia. Among jaundice-free patients with biliary atresia who underwent Kasai portoenterostomy between January 1992 and December 2012, 15 underwent partial splenectomy for massive splenomegaly and hypersplenism at our institution. Changes in the laboratory data 10 years post partial splenectomy were retrospectively investigated, and these along with the latest data were measured. A total of four patients (27%) required living-donor liver transplantation after partial splenectomy, a proportion similar to those who did not undergo partial splenectomy. Compared to the preoperative baseline, the platelet counts were significantly higher at 1 and 3 years after surgery (p < 0.05). Aspartic aminotransferase-to-platelet ratio index was significantly lower at 1, 7, and 10 years after partial splenectomy (p < 0.05). No further surgeries were required for hypersplenism after partial splenectomy over 10 years, and there were no cases of overwhelming post-splenectomy infection after partial splenectomy. Partial splenectomy is safe and effective for the treatment of hypersplenism with biliary atresia over a long time period. It could be considered as an alternative to partial splenic embolization as it can suppress hypersplenism for a long time and induces fewer postoperative complications. |
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言語 |
en |
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内容記述タイプ |
Abstract |
出版者 |
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言語 |
en |
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出版者 |
Nagoya University Graduate School of Medicine, School of Medicine |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
departmental bulletin paper |
出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
ID登録 |
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ID登録 |
10.18999/nagjms.83.4.765 |
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ID登録タイプ |
JaLC |
関連情報 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
URI |
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関連識別子 |
https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/834.html |
収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0027-7622 |
収録物識別子 |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2186-3326 |
書誌情報 |
en : Nagoya Journal of Medical Science
巻 83,
号 4,
p. 765-771,
発行日 2021-11
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