{"_buckets": {"deposit": "5fd825a3-affa-400c-a5de-d6faddf28c0c"}, "_deposit": {"id": "2001663", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2001663"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:02001663", "sets": []}, "author_link": [], "control_number": "2001663", "item_1615768549627": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_9_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "840", "bibliographicPageStart": "827", "bibliographicVolumeNumber": "83", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "Tregs infiltrate tumors and inhibit antitumor immunity. KW-0761 (Mogamulizumab) is a humanized anti-CCR4 monoclonal antibody that could eliminate activated Tregs with high immunosuppressive activity that express CCR4. In this phase Ib trial, KW-0761 was used as a cancer immunotherapeutic reagent to deplete Tregs in patients with advanced or recurrent solid CCR4-negative tumors. Thirty-nine patients with solid cancer were treated with KW-0761 at a dose of 0.1 or 1.0 mg/kg. The safety, clinical responses, and effects of Treg depletion were analyzed. Any grade and grade 3\u20134 treatment-related adverse events (AEs) were observed in 36 (92%) and 14 (36%) out of 39 patients, respectively. All treatment-related AEs were manageable. One and 5 patients achieved a partial response and stable disease, respectively, during treatment and were long survivors. The efficient depletion of Treg in peripheral blood was confirmed in both cohorts. Therefore, the administration of KW-0761 was safe, resulting in the depletion of Tregs in peripheral blood and potential immune responses in patients with solid cancer. The combined use of KW-0761 to deplete Tregs and other immunotherapies is a promising approach to augment immune responses.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}, {"subitem_description": "This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International\nLicense. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/).", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_9_identifier_registration": {"attribute_name": "ID\u767b\u9332", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.83.4.827", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University Graduate School of Medicine, School of Medicine", "subitem_publisher_language": "en"}]}, "item_9_relation_43": {"attribute_name": "\u95a2\u9023\u60c5\u5831", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/834.html", "subitem_relation_type_select": "URI"}}]}, "item_9_source_id_7": {"attribute_name": "\u53ce\u9332\u7269\u8b58\u5225\u5b50", 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"en"}]}, {"creatorNames": [{"creatorName": "Nakajima, Jun", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Seto, Yasuyuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kakimi, Kazuhiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Iida, Shinsuke", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Doki, Yuichiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Oka, Mikio", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ueda, Ryuzo", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Wada, Hisashi", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2021-12-03"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "15-2_Saito.pdf", "filesize": [{"value": "548 KB"}], 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"attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Phase Ib study on the humanized anti-CCR4 antibody, KW-0761, in advanced solid tumors", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Phase Ib study on the humanized anti-CCR4 antibody, KW-0761, in advanced solid tumors", "subitem_title_language": "en"}]}, "item_type_id": "40001", "owner": "1", "path": ["499/508/509/1638493189962"], "permalink_uri": "https://doi.org/10.18999/nagjms.83.4.827", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2021-12-03"}, "publish_date": "2021-12-03", "publish_status": "0", "recid": "2001663", "relation": {}, "relation_version_is_last": true, "title": ["Phase Ib study on the humanized anti-CCR4 antibody, KW-0761, in advanced solid tumors"], "weko_shared_id": -1}