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  1. C100 医学部/医学系研究科
  2. C100b 刊行物
  3. Nagoya journal of medical science
  4. 83(4)

Phase Ib study on the humanized anti-CCR4 antibody, KW-0761, in advanced solid tumors

https://doi.org/10.18999/nagjms.83.4.827
https://doi.org/10.18999/nagjms.83.4.827
9011daf6-f9c8-4ded-bd66-f9d8feb8b670
名前 / ファイル ライセンス アクション
15-2_Saito.pdf 15-2_Saito.pdf (548 KB)
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Item type itemtype_ver1(1)
公開日 2021-12-03
タイトル
タイトル Phase Ib study on the humanized anti-CCR4 antibody, KW-0761, in advanced solid tumors
言語 en
著者 Saito, Takuro

× Saito, Takuro

en Saito, Takuro

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Kurose, Koji

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en Kurose, Koji

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Kojima, Takashi

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en Kojima, Takashi

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Funakoshi, Takeru

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en Funakoshi, Takeru

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Sato, Eiichi

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en Sato, Eiichi

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Nishikawa, Hiroyoshi

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en Nishikawa, Hiroyoshi

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Nakajima, Jun

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en Nakajima, Jun

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Seto, Yasuyuki

× Seto, Yasuyuki

en Seto, Yasuyuki

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Kakimi, Kazuhiro

× Kakimi, Kazuhiro

en Kakimi, Kazuhiro

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Iida, Shinsuke

× Iida, Shinsuke

en Iida, Shinsuke

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Doki, Yuichiro

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en Doki, Yuichiro

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Oka, Mikio

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en Oka, Mikio

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Ueda, Ryuzo

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en Ueda, Ryuzo

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Wada, Hisashi

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en Wada, Hisashi

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報Resource http://creativecommons.org/licenses/by-nc-nd/4.0/
権利情報 Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
キーワード
言語 en
主題Scheme Other
主題 solid cancer patients
キーワード
言語 en
主題Scheme Other
主題 mogamulizumab
キーワード
言語 en
主題Scheme Other
主題 regulatory T cells
キーワード
言語 en
主題Scheme Other
主題 clinical trial
キーワード
言語 en
主題Scheme Other
主題 CCR4
内容記述
内容記述タイプ Abstract
内容記述 Tregs infiltrate tumors and inhibit antitumor immunity. KW-0761 (Mogamulizumab) is a humanized anti-CCR4 monoclonal antibody that could eliminate activated Tregs with high immunosuppressive activity that express CCR4. In this phase Ib trial, KW-0761 was used as a cancer immunotherapeutic reagent to deplete Tregs in patients with advanced or recurrent solid CCR4-negative tumors. Thirty-nine patients with solid cancer were treated with KW-0761 at a dose of 0.1 or 1.0 mg/kg. The safety, clinical responses, and effects of Treg depletion were analyzed. Any grade and grade 3–4 treatment-related adverse events (AEs) were observed in 36 (92%) and 14 (36%) out of 39 patients, respectively. All treatment-related AEs were manageable. One and 5 patients achieved a partial response and stable disease, respectively, during treatment and were long survivors. The efficient depletion of Treg in peripheral blood was confirmed in both cohorts. Therefore, the administration of KW-0761 was safe, resulting in the depletion of Tregs in peripheral blood and potential immune responses in patients with solid cancer. The combined use of KW-0761 to deplete Tregs and other immunotherapies is a promising approach to augment immune responses.
言語 en
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語 en
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/nagjms.83.4.827
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/834.html
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0027-7622
収録物識別子
収録物識別子タイプ EISSN
収録物識別子 2186-3326
書誌情報 en : Nagoya Journal of Medical Science

巻 83, 号 4, p. 827-840, 発行日 2021-11
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