Item type |
itemtype_ver1(1) |
公開日 |
2021-12-13 |
タイトル |
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タイトル |
Important Role of Concomitant Lymphangiogenesis for Reparative Angiogenesis in Hindlimb Ischemia |
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言語 |
en |
著者 |
Pu, Zhongyue
Shimizu, Yuuki
Tsuzuki, Kazuhito
Suzuki, Junya
Hayashida, Ryo
Kondo, Kazuhisa
Fujikawa, Yusuke
Unno, Kazumasa
Ohashi, Koji
Takefuji, Mikito
Bando, Yasuko K.
Ouchi, Noriyuki
Calvert, John W.
Shibata, Rei
Murohara, Toyoaki
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
内容記述 |
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内容記述 |
Objective: Lymphatic vessels are distributed throughout the body and tightly collaborate with blood vessels to maintain tissue homeostasis. However, the functional roles of lymphangiogenesis in the process of reparative angiogenesis in ischemic tissues are largely unknown. Accordingly, we investigated potential roles of lymphangiogenesis using a mouse model of ischemia-induced angiogenesis. Approach and Results: Male C57BL/6J mice were subjected to unilateral hindlimb ischemia, in which not only angiogenesis but also lymphangiogenesis was induced. Next, the excessive and prolonged tissue edema model significantly deteriorated reparative angiogenesis and blood perfusion recovery in ischemic limbs. Finally, implantation of adipose-derived regenerative cells augmented ischemia-induced lymphangiogenesis, which was accompanied by reduced tissue edema and inflammation, resulting in improving reparative angiogenesis and blood perfusion recovery. In addition, inhibition of lymphangiogenesis by MAZ51, a specific VEGFR3 (vascular endothelial cell growth factor receptor 3) inhibitor, resulted in enhanced inflammatory cell infiltration, gene expression of TNF (tumor necrosis factor)-α, IL (interleukin)-1β, IL-6, TGF (transforming growth factor)-β, angiostatin, vasohibin, and endostatin, and tissue edema, resulting in reduced angiogenesis. Conclusions: The lymphatic system may have a clearance role of tissue edema and inflammation, which contribute to functional reparative angiogenesis in response to tissue ischemia. Modulation of lymphangiogenesis would become a novel therapeutic strategy for severe ischemic disease in addition to ordinary vascular intervention and therapeutic angiogenesis. |
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言語 |
en |
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内容記述タイプ |
Abstract |
出版者 |
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言語 |
en |
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出版者 |
American Heart Association |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
関連情報 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1161/ATVBAHA.121.316191 |
収録物識別子 |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1079-5642 |
書誌情報 |
en : Arteriosclerosis, Thrombosis, and Vascular Biology
巻 41,
号 6,
p. 2006-2018,
発行日 2021-06
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ファイル公開日 |
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日付 |
2021-12-13 |
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日付タイプ |
Available |