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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Optimal conditions for graft survival and reinnervation of denervated muscles after embryonic motoneuron transplantation into peripheral nerves undergoing Wallerian degeneration

http://hdl.handle.net/2237/0002001723
http://hdl.handle.net/2237/0002001723
5d5a2824-0021-4baf-a2bf-94e0c356ad79
名前 / ファイル ライセンス アクション
manuscript.pdf manuscript.pdf (7.9 MB)
Item type itemtype_ver1(1)
公開日 2021-12-15
タイトル
タイトル Optimal conditions for graft survival and reinnervation of denervated muscles after embryonic motoneuron transplantation into peripheral nerves undergoing Wallerian degeneration
言語 en
著者 Sawada, Hideyoshi

× Sawada, Hideyoshi

en Sawada, Hideyoshi

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Kurimoto, Shigeru

× Kurimoto, Shigeru

en Kurimoto, Shigeru

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Tokutake, Katsuhiro

× Tokutake, Katsuhiro

en Tokutake, Katsuhiro

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Saeki, Sota

× Saeki, Sota

en Saeki, Sota

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Hirata, Hitoshi

× Hirata, Hitoshi

en Hirata, Hitoshi

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 "This is the peer reviewed version of the following article: [Sawada, H., Kurimoto, S., Tokutake, K., Saeki, S., & Hirata, H. (2021). Optimal conditions for graft survival and reinnervation of denervated muscles after embryonic motoneuron transplantation into peripheral nerves undergoing Wallerian degeneration. Journal of Tissue Engineering and Regenerative Medicine, 15( 9), 763-775. https://doi.org/10.1002/term.3223], which has been published in final form at [https://doi.org/10.1002/term.3223]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited."
内容記述
内容記述 Motoneuron transplantation into peripheral nerves undergoing Wallerian degeneration may have applications in treating diseases causing muscle paralysis. We investigated whether functional reinnervation of denervated muscle could be achieved by early or delayed transplantation after denervation. Adult rats were assigned to six groups with increasing denervation periods (0, 1, 4, 8, 12, and 24 weeks) before inoculation with culture medium containing (transplantation group) or lacking (surgical control group) dissociated embryonic motoneurons into the peroneal nerve. Electrophysiological and tissue analyses were performed 3 months after transplantation. Reinnervation of denervated muscles significantly increased relative muscle weight in the transplantation group compared with the surgical control group for denervation periods of 1 week (0.042% ± 0.0031% vs. 0.032% ± 0.0020%, respectively; p = 0.009), 4 weeks (0.044% ± 0.0069% vs. 0.026% ± 0.0045%, respectively; p = 0.0023), and 8 weeks (0.044% ± 0.0029% vs. 0.026% ± 0.0008%, respectively; p = 0.0023). The ratios of reinnervated muscle contractile forces to naïve muscle in the 0, 1, 4, 8, and 12 weeks transplantation groups were 3.79%, 18.99%, 8.05%, 6.30%, and 5.80%, respectively, indicating that these forces were sufficient for walking. The optimal implantation time for transplantation of motoneurons into the peripheral nerve was 1 week after nerve transection. However, the neurons transplanted 24 weeks after denervation survived and regenerated axons. These results indicated that there is time for preparing cells for transplantation in regenerative medicine and suggested that our method may be useful for paralysed muscles that are not expected to recover with current treatment.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1002/term.3223
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 1932-6254
書誌情報 en : Journal of Tissue Engineering and Regenerative Medicine

巻 15, 号 9, p. 763-775, 発行日 2021-09
ファイル公開日
日付 2022-09-01
日付タイプ Available
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