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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Impact of the extent of resection on the survival of patients with grade II and III gliomas using awake brain mapping

http://hdl.handle.net/2237/0002001767
http://hdl.handle.net/2237/0002001767
3409f268-b4c2-484c-b832-2d31f385329b
名前 / ファイル ライセンス アクション
JOURNAL_OF_NEURO-ONCOLOGY_153_2_2021_361-372.pdf JOURNAL_OF_NEURO-ONCOLOGY_153_2_2021_361-372.pdf (347 KB)
Item type itemtype_ver1(1)
公開日 2021-12-22
タイトル
タイトル Impact of the extent of resection on the survival of patients with grade II and III gliomas using awake brain mapping
言語 en
著者 Motomura, Kazuya

× Motomura, Kazuya

en Motomura, Kazuya

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Chalise, Lushun

× Chalise, Lushun

en Chalise, Lushun

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Ohka, Fumiharu

× Ohka, Fumiharu

en Ohka, Fumiharu

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Aoki, Kosuke

× Aoki, Kosuke

en Aoki, Kosuke

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Tanahashi, Kuniaki

× Tanahashi, Kuniaki

en Tanahashi, Kuniaki

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Hirano, Masaki

× Hirano, Masaki

en Hirano, Masaki

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Nishikawa, Tomohide

× Nishikawa, Tomohide

en Nishikawa, Tomohide

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Yamaguchi, Junya

× Yamaguchi, Junya

en Yamaguchi, Junya

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Shimizu, Hiroyuki

× Shimizu, Hiroyuki

en Shimizu, Hiroyuki

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Wakabayashi, Toshihiko

× Wakabayashi, Toshihiko

en Wakabayashi, Toshihiko

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Saito, Ryuta

× Saito, Ryuta

en Saito, Ryuta

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11060-021-03776-w
内容記述
内容記述 Purpose: The aim of this study was to assess the effect of the extent of resection (EOR) of tumors on survival in a series of patients with grade II and III gliomas (GII/III-gliomas) who underwent awake brain mapping. Methods: We retrospectively analyzed 126 patients with GII/III-gliomas in the dominant and non-dominant hemisphere who underwent awake brain surgery at the same institution between December 2012 and May 2020. Results: EOR cut-off values for improved progression-free survival (PFS) were determined by a receiver operator characteristic (ROC) analysis of 5-year PFS. The ROC for EOR showed a cut-off value of ≥ 85.3%. The median PFS rate of patients with GII/III-gliomas in the group with an EOR ≥ 100%, including supratotal resection (n = 47; median survival [MS], not reached), was significantly higher than that in the group with an EOR < 90% (n = 52; MS, 43.1 months; 95% CI 37.7–48.5 months; p = 0.03). In patients with diffuse astrocytomas and anaplastic astrocytomas, the group with EOR ≥ 100%, including supratotal resection (n = 25; MS, not reached), demonstrated a significantly better PFS rate than did the group with an EOR < 100% (n = 45; MS, 35.8 months; 95% CI 19.9–51.6 months; p = 0.03). Supratotal or gross total resection was correlated with better PFS in IDH-mutant type of diffuse astrocytomas and anaplastic astrocytomas (n = 19; MS, not reached vs. n = 35; MS, 40.6 months; 95% CI 22.3–59.0 months; p = 0.02). By contrast, supratotal or gross total resection was not associated with longer PFS rates in patients with IDH-wild type of diffuse astrocytomas and anaplastic astrocytomas. Conclusions: The present study demonstrates a significant association between tumor EOR and survival in patients with GII/III gliomas. The EOR cut-off value for 5-year PFS was ≥ 85.3%. It is noteworthy that supratotal or gross total resection significantly correlated with better PFS in IDH-mutant type of WHO grade II and III astrocytic tumors. In light of our finding that EOR did not correlate with PFS in patients with aggressive IDH-wild type of diffuse astrocytomas and anaplastic astrocytomas, we suggest treatments that are more intensive will be needed for the control of these tumors.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s11060-021-03776-w
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0167-594X
書誌情報 en : Journal of Neuro-Oncology

巻 153, 号 2, p. 361-372, 発行日 2021-06
ファイル公開日
日付 2022-06-01
日付タイプ Available
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