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Methods: A total of 12 rabbits were randomized to three groups; the ADSCs+fat group (n=4), the fat group (n=4) and the control group (n=4). All rabbits were treated with denervation of the left hypoglossal nerve and their conditions including body weight and food intake were checked during follow-up periods (8 weeks). At 4 weeks after the transection of the nerve, rabbits received the injection therapy into the denervated side of the tongue with 1.0mL fat tissue premixed with 0.5mL ADSCs in the ADSCs+fat group, 1.0mL fat tissue premixed with 0.5mL PBS in the fat group and 1.5mL PBS in the control group. Rabbits were euthanized 8 weeks post-treatment and resected tongues were collected, formalin-fixed and paraffin embedded. To evaluate the change of the intrinsic muscles of the tongue, muscle fibers around the treatment area was analyzed by evaluating 5 consecutive hematoxylin-eosin slides per rabbit. 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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Safety and feasibility of fat injection therapy with adipose-derived stem cells in a rabbit hypoglossal nerve paralysis model: A pilot study

http://hdl.handle.net/2237/0002001951
http://hdl.handle.net/2237/0002001951
2b6fe7c8-ed61-4739-a5bf-9f325f7f58f5
名前 / ファイル ライセンス アクション
ANL-D-20-00143_R1-2.pdf ANL-D-20-00143_R1-2.pdf (7.1 MB)
Item type itemtype_ver1(1)
公開日 2022-01-17
タイトル
タイトル Safety and feasibility of fat injection therapy with adipose-derived stem cells in a rabbit hypoglossal nerve paralysis model: A pilot study
言語 en
著者 Wada, Akihisa

× Wada, Akihisa

en Wada, Akihisa

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Nishio, Naoki

× Nishio, Naoki

en Nishio, Naoki

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Yokoi, Sayaka

× Yokoi, Sayaka

en Yokoi, Sayaka

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Tsuzuki, Hidenori

× Tsuzuki, Hidenori

en Tsuzuki, Hidenori

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Mukoyama, Nobuaki

× Mukoyama, Nobuaki

en Mukoyama, Nobuaki

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Maruo, Takashi

× Maruo, Takashi

en Maruo, Takashi

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Hiramatsu, Mariko

× Hiramatsu, Mariko

en Hiramatsu, Mariko

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Yamamoto, Tokunori

× Yamamoto, Tokunori

en Yamamoto, Tokunori

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Goto, Momokazu

× Goto, Momokazu

en Goto, Momokazu

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Fujimoto, Yasushi

× Fujimoto, Yasushi

en Fujimoto, Yasushi

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Sone, Michihiko

× Sone, Michihiko

en Sone, Michihiko

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
キーワード
主題Scheme Other
主題 Fat injection
キーワード
主題Scheme Other
主題 Adipose-derived stem cell
キーワード
主題Scheme Other
主題 Swallowing disorder
キーワード
主題Scheme Other
主題 Hypoglossal nerve paralysis
キーワード
主題Scheme Other
主題 Rabbit
内容記述
内容記述 Objective: The aim of this study is to establish a unilateral tongue atrophy model by cutting the hypoglossal nerve and to evaluate the safety and feasibility of a fat injection of adipose-derived stem cells (ADSCs) to restore swallowing function. Methods: A total of 12 rabbits were randomized to three groups; the ADSCs+fat group (n=4), the fat group (n=4) and the control group (n=4). All rabbits were treated with denervation of the left hypoglossal nerve and their conditions including body weight and food intake were checked during follow-up periods (8 weeks). At 4 weeks after the transection of the nerve, rabbits received the injection therapy into the denervated side of the tongue with 1.0mL fat tissue premixed with 0.5mL ADSCs in the ADSCs+fat group, 1.0mL fat tissue premixed with 0.5mL PBS in the fat group and 1.5mL PBS in the control group. Rabbits were euthanized 8 weeks post-treatment and resected tongues were collected, formalin-fixed and paraffin embedded. To evaluate the change of the intrinsic muscles of the tongue, muscle fibers around the treatment area was analyzed by evaluating 5 consecutive hematoxylin-eosin slides per rabbit. Results: Food intake did not decrease upon nerve denervation, and none of the rabbits displayed adverse effect such as aspiration, surgical wound dehiscence or infection. No significant body weight changes were found between the three groups at 4 and 8 weeks after nerve transection (p>0.05). In the control group, the denervated side of tongue had significantly smaller muscle fiber areas and diameters compared to the non-denervated side (p<0.05). The ADSCs+fat group demonstrated a larger area of inferior longitudinal muscle fibers compared to the control and the fat groups (582±312µm2 vs. 405±220µm2 and 413±226µm2; p<0.05). A significant thicker lesser diameter of inferior longitudinal muscle fibers was found in the ADSCs+fat group compared to the control and the fat groups (24±8µm vs. 20±6µm and 20±7µm; p<0.05). Conclusion: The rabbit tongue atrophy model was found suitable for the assessment of muscle change after nerve transection. Fat injection therapy with ADSCs demonstrated great potential to prevent the muscle atrophy after denervation and to promote the muscle regeneration around the injection area.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.anl.2020.08.003
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0385-8146
書誌情報 en : Auris Nasus Larynx

巻 48, 号 2, p. 274-280, 発行日 2021-04
ファイル公開日
日付 2022-04-01
日付タイプ Available
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