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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

The impact of chronic Epstein–Barr virus infection on the liver graft of pediatric liver transplant recipients: A retrospective observational study

http://hdl.handle.net/2237/0002002058
http://hdl.handle.net/2237/0002002058
409b4b63-3975-4c3f-a8e8-6d6dde0cc7e6
名前 / ファイル ライセンス アクション
Manuscript_Table_Figure_Final_version.pdf Manuscript_Table_Figure_Final_version.pdf (554 KB)
Item type itemtype_ver1(1)
公開日 2022-02-09
タイトル
タイトル The impact of chronic Epstein–Barr virus infection on the liver graft of pediatric liver transplant recipients: A retrospective observational study
言語 en
著者 Shizuku, Masato

× Shizuku, Masato

en Shizuku, Masato

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Kamei, Hideya

× Kamei, Hideya

en Kamei, Hideya

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Yoshizawa, Atsushi

× Yoshizawa, Atsushi

en Yoshizawa, Atsushi

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Ito, Yoshinori

× Ito, Yoshinori

en Ito, Yoshinori

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Ogura, Yasuhiro

× Ogura, Yasuhiro

en Ogura, Yasuhiro

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Yoshikawa, Junichi

× Yoshikawa, Junichi

en Yoshikawa, Junichi

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Kurata, Nobuhiko

× Kurata, Nobuhiko

en Kurata, Nobuhiko

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Jobara, Kanta

× Jobara, Kanta

en Jobara, Kanta

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Kodera, Yasuhiro

× Kodera, Yasuhiro

en Kodera, Yasuhiro

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the peer reviewed version of the following article: [Shizuku, M, Kamei, H, Yoshizawa, A, et al. The impact of chronic Epstein–Barr virus infection on the liver graft of pediatric liver transplant recipients: A retrospective observational study. Transpl Infect Dis. 2021; 23:e13731. https://doi.org/10.1111/tid.13731], which has been published in final form at [https://doi.org/10.1111/tid.13731]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited."
内容記述
内容記述 Background: Chronic high Epstein–Barr virus loads (CHEBV) are commonly observed in pediatric liver transplant patients. However, it is unclear how CHEBV impacts the liver graft. The aim of this study was to clarify the clinical and pathological impacts of CHEBV on the liver graft. Methods: From 2012 to 2020, we retrospectively investigated 46 pediatric liver transplant patients (under 16 years) who survived ≥6 months. The patients were divided into two groups: CHEBV group (EBV DNA >10 000 IU/ml of whole blood for ≥6 months) and nonchronic high EBV (NCHEBV) group (patients who did not meet CHEBV criteria). Tacrolimus was reduced to <3.0 ng/ml in patients with EBV DNA >5000 IU/ml. Blood biochemistry data and pathological findings, obtained at the time of protocol and episodic biopsies, were compared between the two groups. Results: Out of 46 patients, 28 CHEBV and 18 NCHEBV patients were enrolled. The blood biochemical examination did not show a significant difference between the two groups. In addition, no significant differences between the two groups were found in the pathological findings, including frequency of late acute rejection and the progression of fibrosis at the time of both protocol and episodic biopsies. Appropriate adjustment of immunosuppression for CHEBV management may have contributed to the prevention of the progression of fibrosis. Conclusion: CHEBV had little adverse effect on the liver graft. Graft fibrosis might have been avoided through optimal dose modification of tacrolimus. Further long-term monitoring is necessary because CHEBV may affect the pediatric liver graft in the long term.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/tid.13731
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 1398-2273
書誌情報 en : Transplant Infectious Disease

巻 23, 号 5, p. e13731, 発行日 2021-10
ファイル公開日
日付 2022-10-01
日付タイプ Available
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