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Ketamine reduces the dose of remifentanil required during prolonged head and neck surgery: a propensity-matched analysis
https://doi.org/10.18999/nagjms.84.1.1
https://doi.org/10.18999/nagjms.84.1.123d5d2fb-d185-45d1-bb5e-ef7e1ed6df41
名前 / ファイル | ライセンス | アクション |
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01_Fujii.pdf (613 KB)
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Item type | itemtype_ver1(1) | |||||||||
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公開日 | 2022-02-28 | |||||||||
タイトル | ||||||||||
タイトル | Ketamine reduces the dose of remifentanil required during prolonged head and neck surgery: a propensity-matched analysis | |||||||||
言語 | en | |||||||||
著者 |
Fujii, Tasuku
× Fujii, Tasuku
× Nishiwaki, Kimitoshi
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アクセス権 | ||||||||||
アクセス権 | open access | |||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
権利 | ||||||||||
言語 | en | |||||||||
権利情報Resource | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||
権利情報 | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | head and neck surgery | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | ketamine | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | opioid | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | remifentanil | |||||||||
内容記述 | ||||||||||
内容記述 | High-dose opioids induce hyperalgesia and tolerance, which negatively affects postoperative recovery. Prolonged surgery inevitably requires higher opioid doses. Ketamine reduces perioperative opioid consumption and prevents opioid-induced tolerance. However, its effects in cases of prolonged surgery remain unknown. This study aimed to evaluate the dose of intraoperative remifentanil, an ultrashort-acting μ-opioid agonist, administered after an intravenous ketamine bolus during prolonged head and neck surgery. This single-center, retrospective, observational study included 251 patients who underwent head and neck surgery (operation time ≥8 h) between January 2015 and December 2019. The participants were stratified into two groups: those who received an intravenous bolus of ketamine and those who did not (ketamine group and non-ketamine group, respectively). Propensity score-matching was used to match patients in a 1:1 ratio between the two groups, based on their covariates. The difference in intraoperative remifentanil dose administered between the two groups was assessed. After 1:1 propensity score-matching, 89 matched patients were selected from each group. The mean ± standard deviation dose of remifentanil administered was significantly lower in the ketamine group than in the non-ketamine group before (0.15±0.05 vs 0.17±0.05 μg/kg/min; P=0.01) and after matching (0.15±0.06 vs 0.17±0.05 μg/kg/min; P=0.03). In conclusion, intravenous ketamine administration may reduce the intraoperative dose of remifentanil required during prolonged head and neck surgery. However, further studies are required to evaluate the effect of this finding on enhanced recovery after surgery. | |||||||||
言語 | en | |||||||||
内容記述タイプ | Abstract | |||||||||
出版者 | ||||||||||
言語 | en | |||||||||
出版者 | Nagoya University Graduate School of Medicine, School of Medicine | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
資源タイプ | ||||||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||||||
タイプ | departmental bulletin paper | |||||||||
出版タイプ | ||||||||||
出版タイプ | VoR | |||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
ID登録 | ||||||||||
ID登録 | 10.18999/nagjms.84.1.1 | |||||||||
ID登録タイプ | JaLC | |||||||||
関連情報 | ||||||||||
関連タイプ | isVersionOf | |||||||||
識別子タイプ | URI | |||||||||
関連識別子 | https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/841.html | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | PISSN | |||||||||
収録物識別子 | 0027-7622 | |||||||||
収録物識別子 | ||||||||||
収録物識別子タイプ | EISSN | |||||||||
収録物識別子 | 2186-3326 | |||||||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 84, 号 1, p. 1-6, 発行日 2022-02 |