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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 84(1)

DNA methylation is associated with muscle loss in community-dwelling older men -the Yakumo study-: a preliminary experimental study

https://doi.org/10.18999/nagjms.84.1.60
https://doi.org/10.18999/nagjms.84.1.60
6125762b-92bd-4297-8283-757d8a325d6f
名前 / ファイル ライセンス アクション
06_D-Kato.pdf 06_D-Kato.pdf (861 KB)
Item type itemtype_ver1(1)
公開日 2022-02-28
タイトル
タイトル DNA methylation is associated with muscle loss in community-dwelling older men -the Yakumo study-: a preliminary experimental study
言語 en
著者 Kato, Daisaku

× Kato, Daisaku

en Kato, Daisaku

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Takegami, Yasuhiko

× Takegami, Yasuhiko

en Takegami, Yasuhiko

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Seki, Taisuke

× Seki, Taisuke

en Seki, Taisuke

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Nakashima, Hiroaki

× Nakashima, Hiroaki

en Nakashima, Hiroaki

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Osawa, Yusuke

× Osawa, Yusuke

en Osawa, Yusuke

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Suzuki, Koji

× Suzuki, Koji

en Suzuki, Koji

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Yamada, Hiroya

× Yamada, Hiroya

en Yamada, Hiroya

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Hasegawa, Yukiharu

× Hasegawa, Yukiharu

en Hasegawa, Yukiharu

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Imagama, Shiro

× Imagama, Shiro

en Imagama, Shiro

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
言語 en
主題Scheme Other
主題 cross-sectional study
キーワード
言語 en
主題Scheme Other
主題 frailty
キーワード
言語 en
主題Scheme Other
主題 LINE-1 DNA methylation
キーワード
言語 en
主題Scheme Other
主題 muscle loss
キーワード
言語 en
主題Scheme Other
主題 osteoporosis
内容記述
内容記述 Frailty is a state of reduced muscle strength and activity in older people. DNA methylation is associated with osteoporosis and muscle loss in murine and other animal studies, but there are no epidemiological studies in humans. This study aimed to assess the association of osteoporosis and muscle loss with DNA methylation in community-dwelling older people. This cross-sectional study was performed in a rural part of Japan. We analyzed 204 subjects (98 men and 106 women). In univariate analysis, the two groups were compared according to the presence or absence of osteoporosis and of muscle loss. Logistic regression analysis was performed to determine predictors of frailty in the muscle loss group. We used age, sex, body mass index, smoking history, drinking history, serum albumin and C-reactive protein levels, diabetes, hypertension, hyperlipidemia, heart disease history, and LINE-1 DNA methylation as the factors. Probability values < 0.05 were considered to be statistically significant. The levels of LINE-1 DNA methylation in leukocytes were associated with muscle loss in men over the age of 60. LINE-1 DNA methylation levels were not associated with bone mineral density in either the men or women over the age of 60. LINE-1 DNA methylation levels in leukocytes correlated significantly with the risk of frailty in men over the age of 60. Promoting an understanding of DNA methylation may lead to a better understanding of the pathophysiology of muscle loss.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/).
言語 en
内容記述タイプ Other
出版者
言語 en
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/nagjms.84.1.60
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/841.html
助成情報
助成機関名 日本学術振興会
言語 ja
助成機関名 Japan Society for the Promotion of Science
言語 en
研究課題番号URI https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293144/
研究課題番号 26293144
研究課題名 長期追跡コホート研究の保存白血球を用いたDNAのメチル化解析
言語 ja
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0027-7622
収録物識別子
収録物識別子タイプ EISSN
収録物識別子 2186-3326
書誌情報 en : Nagoya Journal of Medical Science

巻 84, 号 1, p. 60-68, 発行日 2022-02
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