{"_buckets": {"deposit": "3aba6ee7-9298-4b3c-817b-88692ff33cc1"}, "_deposit": {"id": "2002130", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2002130"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:02002130", "sets": []}, "author_link": [], "control_number": "2002130", "item_1615768549627": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_9_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2022-02", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "179", "bibliographicPageStart": "169", "bibliographicVolumeNumber": "84", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "Ulcerative colitis (UC) is an incurable, chronic inflammatory disease of the large bowel whose etiology and pathogenesis have not yet been comprehensively explained. Tofacitinib is a small molecule Janus kinase inhibitor that was introduced for treating refractory UC. We aimed to examine the efficacy and safety of tofacitinib for the treatment of 18 patients with UC. Continuous treatment rates were 50, 38, and 33% at 8, 24, and 52 weeks, respectively. Overall, 83.3% of these patients showed tumor necrosis factor (TNF) antibody failure status. When the effective status was defined as a Lichtiger index (LI) that decreased by 3 points or more or was less than 4 points and remission status was defined as an LI less than 4 points, the effective and remission rates (%) at 2, 8, and 16 weeks were 55.5 (10/18) and 22.2 (4/18), 38.8 (7/18) and 33.3 (6/18), and 38.8 (7/18) and 38.8 (7/18), respectively. Background characteristics of 2-week responders and non-responders were compared. C-reactive protein level in responders was significantly lower than that in non-responders, and the hemoglobin level in responders was significantly higher than that in non-responders. This study provides preliminary results of the effectiveness of tofacitinib even for TNF antibody and tacrolimus failure patients.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}, {"subitem_description": "This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/).", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_9_identifier_registration": {"attribute_name": "ID\u767b\u9332", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.84.1.169", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University Graduate School of Medicine, School of Medicine", "subitem_publisher_language": "en"}]}, "item_9_relation_43": {"attribute_name": "\u95a2\u9023\u60c5\u5831", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/841.html", "subitem_relation_type_select": "URI"}}]}, "item_9_source_id_7": {"attribute_name": "\u53ce\u9332\u7269\u8b58\u5225\u5b50", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "PISSN"}, {"subitem_source_identifier": "2186-3326", "subitem_source_identifier_type": "EISSN"}]}, "item_access_right": {"attribute_name": "\u30a2\u30af\u30bb\u30b9\u6a29", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nakamura, Masanao", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yamamura, Takeshi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Maeda, Keiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Sawada, Tsunaki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Mizutani, Yasuyuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ishikawa, Eri", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ishikawa, Takuya", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kakushima, Naomi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Furukawa, Kazuhiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ohno, Eizaburo", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kawashima, Hiroki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Honda, Takashi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ishigami, Masatoshi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Fujishiro, Mitsuhiro", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2022-02-28"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "18_Nakamura.pdf", "filesize": [{"value": "4.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "application/pdf", "size": 4200000.0, "url": {"objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/2002130/files/18_Nakamura.pdf"}, "version_id": "03f1161d-6f8c-468d-adb4-d45a437b17f6"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "ulcerative colitis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "refractory", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tofacitinib", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "case reports", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Initial experience of tofacitinib for treating refractory moderate-to-severe ulcerative colitis", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Initial experience of tofacitinib for treating refractory moderate-to-severe ulcerative colitis", "subitem_title_language": "en"}]}, "item_type_id": "40001", "owner": "1", "path": ["499/508/509/1646019880489"], "permalink_uri": "https://doi.org/10.18999/nagjms.84.1.169", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-02-28"}, "publish_date": "2022-02-28", "publish_status": "0", "recid": "2002130", "relation": {}, "relation_version_is_last": true, "title": ["Initial experience of tofacitinib for treating refractory moderate-to-severe ulcerative colitis"], "weko_shared_id": -1}