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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Hypertensive disorders of pregnancy and alterations in brain metabolites in preterm infants: A multi-voxel proton MR spectroscopy study

http://hdl.handle.net/2237/0002002197
http://hdl.handle.net/2237/0002002197
164be965-5943-4d39-96f9-f7209aaa804d
名前 / ファイル ライセンス アクション
HDP_and_MRS_2021_9_23.pdf HDP_and_MRS_2021_9_23.pdf (440 KB)
Item type itemtype_ver1(1)
公開日 2022-03-11
タイトル
タイトル Hypertensive disorders of pregnancy and alterations in brain metabolites in preterm infants: A multi-voxel proton MR spectroscopy study
言語 en
著者 Katsuki, Satoru

× Katsuki, Satoru

en Katsuki, Satoru

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Ushida, Takafumi

× Ushida, Takafumi

en Ushida, Takafumi

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Kidokoro, Hiroyuki

× Kidokoro, Hiroyuki

en Kidokoro, Hiroyuki

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Nakamura, Noriyuki

× Nakamura, Noriyuki

en Nakamura, Noriyuki

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Iitani, Yukako

× Iitani, Yukako

en Iitani, Yukako

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Fuma, Kazuya

× Fuma, Kazuya

en Fuma, Kazuya

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Imai, Kenji

× Imai, Kenji

en Imai, Kenji

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Nakano-Kobayashi, Tomoko

× Nakano-Kobayashi, Tomoko

en Nakano-Kobayashi, Tomoko

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Sato, Yoshiaki

× Sato, Yoshiaki

en Sato, Yoshiaki

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Hayakawa, Masahiro

× Hayakawa, Masahiro

en Hayakawa, Masahiro

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Natsume, Jun

× Natsume, Jun

en Natsume, Jun

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Kajiyama, Hiroaki

× Kajiyama, Hiroaki

en Kajiyama, Hiroaki

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Kotani, Tomomi

× Kotani, Tomomi

en Kotani, Tomomi

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
キーワード
主題Scheme Other
主題 Brain metabolites
キーワード
主題Scheme Other
主題 Hypertensive disorders of pregnancy
キーワード
主題Scheme Other
主題 Magnetic resonance spectroscopy
キーワード
主題Scheme Other
主題 Neurodevelopment
キーワード
主題Scheme Other
主題 Preterm infants
内容記述
内容記述 Background: Infants born to mothers with hypertensive disorders of pregnancy (HDP) have adverse neurodevelopmental consequences in later life. Magnetic resonance spectroscopy (MRS) is used to predict subsequent neurodevelopment in the field of perinatology. Aim: We aimed to determine whether exposure to HDP in utero leads to alterations in brain metabolites in preterm infants using multi-voxel proton MRS at term-equivalent age. Study design: Retrospective cohort study. Subjects: A total of 103 preterm infants born before 34 weeks of gestation at Nagoya University Hospital between 2010 and 2018 were eligible. Twenty-seven infants were born to mothers with HDP (HDP group), and 76 were born to mothers without HDP (non-HDP group). Outcome measures: The peak area ratios of N-acetylaspartate (NAA)/choline (Cho), NAA/creatine (Cr), and Cho/Cr were evaluated at 10 designated regions of interest (bilateral frontal lobes, basal ganglia, thalami, temporal lobes, and occipital lobes). Results: The peak area ratios of NAA/Cho and NAA/Cr in the bilateral thalami were significantly higher in the HDP group than in the non-HDP group after adjustment for covariates (postmenstrual age at MRS assessment and infant sex). No significant differences were observed in other regions. Preeclampsia, abnormal umbilical artery blood flow, and fetal growth restrictions were significantly associated with increased NAA/Cho and NAA/Cr ratios in the thalami. Conclusions: Based on the evidence that NAA/Cho and NAA/Cr ratios constantly increase with postmenstrual age in normal brain development, exposure to maternal HDP in utero may accelerate brain maturation and increase neuronal activity in preterm infants.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.earlhumdev.2021.105479
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0378-3782
書誌情報 en : Early Human Development

巻 163, p. 105479, 発行日 2021-12
ファイル公開日
日付 2022-12-01
日付タイプ Available
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