Item type |
itemtype_ver1(1) |
公開日 |
2022-03-11 |
タイトル |
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タイトル |
Hypertensive disorders of pregnancy and alterations in brain metabolites in preterm infants: A multi-voxel proton MR spectroscopy study |
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言語 |
en |
著者 |
Katsuki, Satoru
Ushida, Takafumi
Kidokoro, Hiroyuki
Nakamura, Noriyuki
Iitani, Yukako
Fuma, Kazuya
Imai, Kenji
Nakano-Kobayashi, Tomoko
Sato, Yoshiaki
Hayakawa, Masahiro
Natsume, Jun
Kajiyama, Hiroaki
Kotani, Tomomi
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アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
権利 |
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言語 |
en |
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権利情報 |
© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
キーワード |
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主題Scheme |
Other |
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主題 |
Brain metabolites |
キーワード |
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主題Scheme |
Other |
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主題 |
Hypertensive disorders of pregnancy |
キーワード |
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主題Scheme |
Other |
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主題 |
Magnetic resonance spectroscopy |
キーワード |
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主題Scheme |
Other |
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主題 |
Neurodevelopment |
キーワード |
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主題Scheme |
Other |
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主題 |
Preterm infants |
内容記述 |
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内容記述 |
Background: Infants born to mothers with hypertensive disorders of pregnancy (HDP) have adverse neurodevelopmental consequences in later life. Magnetic resonance spectroscopy (MRS) is used to predict subsequent neurodevelopment in the field of perinatology. Aim: We aimed to determine whether exposure to HDP in utero leads to alterations in brain metabolites in preterm infants using multi-voxel proton MRS at term-equivalent age. Study design: Retrospective cohort study. Subjects: A total of 103 preterm infants born before 34 weeks of gestation at Nagoya University Hospital between 2010 and 2018 were eligible. Twenty-seven infants were born to mothers with HDP (HDP group), and 76 were born to mothers without HDP (non-HDP group). Outcome measures: The peak area ratios of N-acetylaspartate (NAA)/choline (Cho), NAA/creatine (Cr), and Cho/Cr were evaluated at 10 designated regions of interest (bilateral frontal lobes, basal ganglia, thalami, temporal lobes, and occipital lobes). Results: The peak area ratios of NAA/Cho and NAA/Cr in the bilateral thalami were significantly higher in the HDP group than in the non-HDP group after adjustment for covariates (postmenstrual age at MRS assessment and infant sex). No significant differences were observed in other regions. Preeclampsia, abnormal umbilical artery blood flow, and fetal growth restrictions were significantly associated with increased NAA/Cho and NAA/Cr ratios in the thalami. Conclusions: Based on the evidence that NAA/Cho and NAA/Cr ratios constantly increase with postmenstrual age in normal brain development, exposure to maternal HDP in utero may accelerate brain maturation and increase neuronal activity in preterm infants. |
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言語 |
en |
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内容記述タイプ |
Abstract |
出版者 |
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言語 |
en |
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出版者 |
Elsevier |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
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タイプ |
journal article |
出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
関連情報 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.earlhumdev.2021.105479 |
収録物識別子 |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0378-3782 |
書誌情報 |
en : Early Human Development
巻 163,
p. 105479,
発行日 2021-12
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ファイル公開日 |
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日付 |
2022-12-01 |
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日付タイプ |
Available |