| Item type |
itemtype_ver1(1) |
| 公開日 |
2022-03-23 |
| タイトル |
|
|
タイトル |
Urinary N1,N12-diacetylspermine as a biomarker for pediatric cancer: a case–control study |
|
言語 |
en |
| 著者 |
Yokota, Kazuki
Hinoki, Akinari
Hiramatsu, Kyoko
Amano, Hizuru
Kawamura, Machiko
Kuwatsuka, Yachiyo
Tainaka, Takahisa
Shirota, Chiyoe
Sumida, Wataru
Makita, Satoshi
Okamoto, Masamune
Takimoto, Aitaro
Yasui, Akihiro
Nakagawa, Yoichi
Uchida, Hiroo
Kawakita, Masao
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
|
|
言語 |
en |
|
権利情報 |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00383-021-04987-y |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Malignant lymphoma |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Urinary tumor marker |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Polyamine |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
N1,N12-diacetylspermine |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Pediatric cancer |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Purpose: Minimally invasive examinations are particularly important in pediatric patients. Although the significance of urinary N1,N12-diacetylspermine (DiAcSpm) as a tumor marker (TM) has been reported in many types of adult cancers, its usefulness in pediatric cancers has not been reported. This may be due to urinary DiAcSpm level variations with age. This study aims to measure the normal levels of urinary DiAcSpm in healthy individuals and investigate its usefulness as a TM in childhood cancer. Methods: Urinary samples were collected from pediatric patients with and without cancer. The urinary DiAcSpm levels were measured, and the values were compared. Results: A total of 32 patients with cancer and 405 controls were enrolled in the study. Of the 32 patients, 13 had neuroblastoma, 9 had malignant lymphoma (ML), and 10 had leukemia. In the control group, the urinary DiAcSpm values markedly fluctuated among those with young age, especially infants; meanwhile, the values converged among those aged roughly 10 years and above. The sensitivity of DiAcSpm was significantly different among the three types of cancers: neuroblastoma (30.8%), ML (77.8%), and leukemia (40%). Conclusion: The urinary DiAcSpm value is a useful TM for both screening and follow-up of ML. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Springer |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1007/s00383-021-04987-y |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0179-0358 |
| 書誌情報 |
en : Pediatric Surgery International
巻 37,
号 12,
p. 1659-1665,
発行日 2021-12
|
| ファイル公開日 |
|
|
日付 |
2022-12-01 |
|
日付タイプ |
Available |
Yokota_K_Urinary_N1_repository.pdf (504 KB)
