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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Urinary N1,N12-diacetylspermine as a biomarker for pediatric cancer: a case–control study

http://hdl.handle.net/2237/0002002235
http://hdl.handle.net/2237/0002002235
7c0d8d4d-3f6b-4080-8852-c657755ffb62
名前 / ファイル ライセンス アクション
Yokota_K_Urinary_N1_repository.pdf Yokota_K_Urinary_N1_repository.pdf (504 KB)
Item type itemtype_ver1(1)
公開日 2022-03-23
タイトル
タイトル Urinary N1,N12-diacetylspermine as a biomarker for pediatric cancer: a case–control study
言語 en
著者 Yokota, Kazuki

× Yokota, Kazuki

en Yokota, Kazuki

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Hinoki, Akinari

× Hinoki, Akinari

en Hinoki, Akinari

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Hiramatsu, Kyoko

× Hiramatsu, Kyoko

en Hiramatsu, Kyoko

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Amano, Hizuru

× Amano, Hizuru

en Amano, Hizuru

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Kawamura, Machiko

× Kawamura, Machiko

en Kawamura, Machiko

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Kuwatsuka, Yachiyo

× Kuwatsuka, Yachiyo

en Kuwatsuka, Yachiyo

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Tainaka, Takahisa

× Tainaka, Takahisa

en Tainaka, Takahisa

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Shirota, Chiyoe

× Shirota, Chiyoe

en Shirota, Chiyoe

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Sumida, Wataru

× Sumida, Wataru

en Sumida, Wataru

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Makita, Satoshi

× Makita, Satoshi

en Makita, Satoshi

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Okamoto, Masamune

× Okamoto, Masamune

en Okamoto, Masamune

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Takimoto, Aitaro

× Takimoto, Aitaro

en Takimoto, Aitaro

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Yasui, Akihiro

× Yasui, Akihiro

en Yasui, Akihiro

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Nakagawa, Yoichi

× Nakagawa, Yoichi

en Nakagawa, Yoichi

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Uchida, Hiroo

× Uchida, Hiroo

en Uchida, Hiroo

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Kawakita, Masao

× Kawakita, Masao

en Kawakita, Masao

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00383-021-04987-y
キーワード
主題Scheme Other
主題 Malignant lymphoma
キーワード
主題Scheme Other
主題 Urinary tumor marker
キーワード
主題Scheme Other
主題 Polyamine
キーワード
主題Scheme Other
主題 N1,N12-diacetylspermine
キーワード
主題Scheme Other
主題 Pediatric cancer
内容記述
内容記述 Purpose: Minimally invasive examinations are particularly important in pediatric patients. Although the significance of urinary N1,N12-diacetylspermine (DiAcSpm) as a tumor marker (TM) has been reported in many types of adult cancers, its usefulness in pediatric cancers has not been reported. This may be due to urinary DiAcSpm level variations with age. This study aims to measure the normal levels of urinary DiAcSpm in healthy individuals and investigate its usefulness as a TM in childhood cancer. Methods: Urinary samples were collected from pediatric patients with and without cancer. The urinary DiAcSpm levels were measured, and the values were compared. Results: A total of 32 patients with cancer and 405 controls were enrolled in the study. Of the 32 patients, 13 had neuroblastoma, 9 had malignant lymphoma (ML), and 10 had leukemia. In the control group, the urinary DiAcSpm values markedly fluctuated among those with young age, especially infants; meanwhile, the values converged among those aged roughly 10 years and above. The sensitivity of DiAcSpm was significantly different among the three types of cancers: neuroblastoma (30.8%), ML (77.8%), and leukemia (40%). Conclusion: The urinary DiAcSpm value is a useful TM for both screening and follow-up of ML.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s00383-021-04987-y
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0179-0358
書誌情報 en : Pediatric Surgery International

巻 37, 号 12, p. 1659-1665, 発行日 2021-12
ファイル公開日
日付 2022-12-01
日付タイプ Available
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