| Item type |
itemtype_ver1(1) |
| 公開日 |
2022-05-10 |
| タイトル |
|
|
タイトル |
Impact of synbiotics treatment on bacteremia induced during neoadjuvant chemotherapy for esophageal cancer: A randomised controlled trial |
|
言語 |
en |
| 著者 |
Fukaya, Masahide
Yokoyama, Yukihiro
Usui, Hiroaki
Fujieda, Hironori
Sakatoku, Yayoi
Takahashi, Takamasa
Miyata, Kazushi
Niikura, Mai
Sugimoto, Takuya
Asahara, Takashi
Nagino, Masato
Ebata, Tomoki
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
|
|
言語 |
en |
|
権利情報 |
© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Synbiotics |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Neoadjuvant chemotherapy |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Esophageal cancer |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Bacterial translocation |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background & aims: To elucidate the impact of synbiotics on bacterial translocation and subsequent bacteremia during neoadjuvant chemotherapy for esophageal cancer. Methods: Patients requiring neoadjuvant chemotherapy for esophageal cancer were randomized to receive synbiotics (synbiotics group) or no synbiotics (control group) during chemotherapy. Blood and fecal samples were taken before and after every chemotherapy cycle, and 1 day before surgery. Mesenteric lymph nodes (MLNs) were harvested at laparotomy (MLN-1) and after resection of the tumor (MLN-2). Bacteria in each sample were detected. Fecal microbiota and organic acid concentrations were also determined. The primary endpoint was the detection of bacteria in the blood samples, as well as the incidence of side effects during chemotherapy. The secondary endpoint was the detection rate of bacteria in the MLN samples collected during surgery. Results: The study recruited a total of 42 patients (22 in the control group, 20 in the synbiotics group). Bacteria were detected in 16 of 101 blood samples in the control group, whereas those were detected only 2 of 100 blood samples in the synbiotics group (p < 0.001) during neoadjuvant chemotherapy. Additionally, bacteria were detected in 12 of 34 MLN samples in the control group, whereas no bacteria were detected in 38 MLN samples in the synbiotics group (p < 0.001). Suppression of bacterial translocation was at least partly associated with an increased fecal acetic acid concentration as well as a lowered fecal pH by synbiotics. The incidence rate of grade 3 gastrointestinal toxicity during chemotherapy was lower in the synbiotics group compared to the control group (8/22 vs. 1/20, p = 0.022). Conclusions: Neoadjuvant chemotherapy for esophageal cancer may induce bacterial translocation and subsequent bacteremia, which can be prevented by synbiotics administration. Trial registration: The University Hospital Medical Information Network (http://www.umin.ac.jp; registration number ID 000007651). |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.clnu.2021.10.004 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0261-5614 |
| 書誌情報 |
en : Clinical Nutrition
巻 40,
号 12,
p. 5781-5791,
発行日 2021-12
|
| ファイル公開日 |
|
|
日付 |
2022-12-01 |
|
日付タイプ |
Available |
EC_Synbio_Clin_Nutr_final.pdf (797 KB)
