ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "6acd4052-f6ed-4ec5-bb35-6b4387ed3982"}, "_deposit": {"created_by": 17, "id": "2002692", "owner": "17", "owners": [17], "owners_ext": {"displayname": "repository", "username": "repository"}, "pid": {"revision_id": 0, "type": "depid", "value": "2002692"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:02002692", "sets": ["501"]}, "author_link": [], "control_number": "2002692", "item_1615768549627": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_1629683748249": {"attribute_name": "日付", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2022-12-01", "subitem_date_issued_type": "Available"}]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "12", "bibliographicPageEnd": "5791", "bibliographicPageStart": "5781", "bibliographicVolumeNumber": "40", "bibliographic_titles": [{"bibliographic_title": "Clinical Nutrition", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Background \u0026 aims: To elucidate the impact of synbiotics on bacterial translocation and subsequent bacteremia during neoadjuvant chemotherapy for esophageal cancer. Methods: Patients requiring neoadjuvant chemotherapy for esophageal cancer were randomized to receive synbiotics (synbiotics group) or no synbiotics (control group) during chemotherapy. Blood and fecal samples were taken before and after every chemotherapy cycle, and 1 day before surgery. Mesenteric lymph nodes (MLNs) were harvested at laparotomy (MLN-1) and after resection of the tumor (MLN-2). Bacteria in each sample were detected. Fecal microbiota and organic acid concentrations were also determined. The primary endpoint was the detection of bacteria in the blood samples, as well as the incidence of side effects during chemotherapy. The secondary endpoint was the detection rate of bacteria in the MLN samples collected during surgery. Results: The study recruited a total of 42 patients (22 in the control group, 20 in the synbiotics group). Bacteria were detected in 16 of 101 blood samples in the control group, whereas those were detected only 2 of 100 blood samples in the synbiotics group (p \u003c 0.001) during neoadjuvant chemotherapy. Additionally, bacteria were detected in 12 of 34 MLN samples in the control group, whereas no bacteria were detected in 38 MLN samples in the synbiotics group (p \u003c 0.001). Suppression of bacterial translocation was at least partly associated with an increased fecal acetic acid concentration as well as a lowered fecal pH by synbiotics. The incidence rate of grade 3 gastrointestinal toxicity during chemotherapy was lower in the synbiotics group compared to the control group (8/22 vs. 1/20, p = 0.022). Conclusions: Neoadjuvant chemotherapy for esophageal cancer may induce bacterial translocation and subsequent bacteremia, which can be prevented by synbiotics administration. Trial registration: The University Hospital Medical Information Network (http://www.umin.ac.jp; registration number ID 000007651).", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier", "subitem_publisher_language": "en"}]}, "item_9_relation_43": {"attribute_name": "関連情報", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.clnu.2021.10.004", "subitem_relation_type_select": "DOI"}}]}, "item_9_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/", "subitem_rights_language": "en"}]}, "item_9_source_id_7": {"attribute_name": "収録物識別子", "attribute_value_mlt": [{"subitem_source_identifier": "0261-5614", "subitem_source_identifier_type": "PISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Fukaya, Masahide", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yokoyama, Yukihiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Usui, Hiroaki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Fujieda, Hironori", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Sakatoku, Yayoi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Takahashi, Takamasa", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Miyata, Kazushi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Niikura, Mai", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Sugimoto, Takuya", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Asahara, Takashi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Nagino, Masato", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ebata, Tomoki", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-12-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "EC_Synbio_Clin_Nutr_final.pdf", "filesize": [{"value": "797 KB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "application/pdf", "size": 797000.0, "url": {"objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/2002692/files/EC_Synbio_Clin_Nutr_final.pdf"}, "version_id": "b7098335-2d5f-4fe9-b0df-2fd400f4fc18"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Synbiotics", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Neoadjuvant chemotherapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Esophageal cancer", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Bacterial translocation", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Impact of synbiotics treatment on bacteremia induced during neoadjuvant chemotherapy for esophageal cancer: A randomised controlled trial", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Impact of synbiotics treatment on bacteremia induced during neoadjuvant chemotherapy for esophageal cancer: A randomised controlled trial", "subitem_title_language": "en"}]}, "item_type_id": "40001", "owner": "17", "path": ["501"], "permalink_uri": "http://hdl.handle.net/2237/0002002692", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-05-10"}, "publish_date": "2022-05-10", "publish_status": "0", "recid": "2002692", "relation": {}, "relation_version_is_last": true, "title": ["Impact of synbiotics treatment on bacteremia induced during neoadjuvant chemotherapy for esophageal cancer: A randomised controlled trial"], "weko_shared_id": -1}
  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Impact of synbiotics treatment on bacteremia induced during neoadjuvant chemotherapy for esophageal cancer: A randomised controlled trial

http://hdl.handle.net/2237/0002002692
http://hdl.handle.net/2237/0002002692
48dc3ee5-45ee-4a3c-a720-62139657045a
名前 / ファイル ライセンス アクション
EC_Synbio_Clin_Nutr_final.pdf EC_Synbio_Clin_Nutr_final.pdf (797 KB)
Item type itemtype_ver1(1)
公開日 2022-05-10
タイトル
タイトル Impact of synbiotics treatment on bacteremia induced during neoadjuvant chemotherapy for esophageal cancer: A randomised controlled trial
言語 en
著者 Fukaya, Masahide

× Fukaya, Masahide

en Fukaya, Masahide

Search repository
Yokoyama, Yukihiro

× Yokoyama, Yukihiro

en Yokoyama, Yukihiro

Search repository
Usui, Hiroaki

× Usui, Hiroaki

en Usui, Hiroaki

Search repository
Fujieda, Hironori

× Fujieda, Hironori

en Fujieda, Hironori

Search repository
Sakatoku, Yayoi

× Sakatoku, Yayoi

en Sakatoku, Yayoi

Search repository
Takahashi, Takamasa

× Takahashi, Takamasa

en Takahashi, Takamasa

Search repository
Miyata, Kazushi

× Miyata, Kazushi

en Miyata, Kazushi

Search repository
Niikura, Mai

× Niikura, Mai

en Niikura, Mai

Search repository
Sugimoto, Takuya

× Sugimoto, Takuya

en Sugimoto, Takuya

Search repository
Asahara, Takashi

× Asahara, Takashi

en Asahara, Takashi

Search repository
Nagino, Masato

× Nagino, Masato

en Nagino, Masato

Search repository
Ebata, Tomoki

× Ebata, Tomoki

en Ebata, Tomoki

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
キーワード
主題Scheme Other
主題 Synbiotics
キーワード
主題Scheme Other
主題 Neoadjuvant chemotherapy
キーワード
主題Scheme Other
主題 Esophageal cancer
キーワード
主題Scheme Other
主題 Bacterial translocation
内容記述
内容記述 Background & aims: To elucidate the impact of synbiotics on bacterial translocation and subsequent bacteremia during neoadjuvant chemotherapy for esophageal cancer. Methods: Patients requiring neoadjuvant chemotherapy for esophageal cancer were randomized to receive synbiotics (synbiotics group) or no synbiotics (control group) during chemotherapy. Blood and fecal samples were taken before and after every chemotherapy cycle, and 1 day before surgery. Mesenteric lymph nodes (MLNs) were harvested at laparotomy (MLN-1) and after resection of the tumor (MLN-2). Bacteria in each sample were detected. Fecal microbiota and organic acid concentrations were also determined. The primary endpoint was the detection of bacteria in the blood samples, as well as the incidence of side effects during chemotherapy. The secondary endpoint was the detection rate of bacteria in the MLN samples collected during surgery. Results: The study recruited a total of 42 patients (22 in the control group, 20 in the synbiotics group). Bacteria were detected in 16 of 101 blood samples in the control group, whereas those were detected only 2 of 100 blood samples in the synbiotics group (p < 0.001) during neoadjuvant chemotherapy. Additionally, bacteria were detected in 12 of 34 MLN samples in the control group, whereas no bacteria were detected in 38 MLN samples in the synbiotics group (p < 0.001). Suppression of bacterial translocation was at least partly associated with an increased fecal acetic acid concentration as well as a lowered fecal pH by synbiotics. The incidence rate of grade 3 gastrointestinal toxicity during chemotherapy was lower in the synbiotics group compared to the control group (8/22 vs. 1/20, p = 0.022). Conclusions: Neoadjuvant chemotherapy for esophageal cancer may induce bacterial translocation and subsequent bacteremia, which can be prevented by synbiotics administration. Trial registration: The University Hospital Medical Information Network (http://www.umin.ac.jp; registration number ID 000007651).
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.clnu.2021.10.004
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0261-5614
書誌情報 en : Clinical Nutrition

巻 40, 号 12, p. 5781-5791, 発行日 2021-12
ファイル公開日
日付 2022-12-01
日付タイプ Available
戻る
0
views
See details
Views

Versions

Ver.1 2022-05-10 01:33:00.452931
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3